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Sr Python Full Stack Developer Jobs in Missouri (NOW HIRING)

Senior Python Developer

Fenton, MO · On-site

$116K - $156K/yr

The Senior Python Developer is responsible for designing, developing, and maintaining complex ... Responsibilities : • Designs, develops and maintains Python applications • Is a Full-Life Cycle ...

As a senior engineer, you'll combine hands-on coding with architectural leadership , ensuring our ... Write and review production-quality code in modern languages such as C#, Java, Python, or Go.

As a senior engineer, you'll combine hands-on coding with architectural leadership , ensuring our ... Write and review production-quality code in modern languages such as C#, Java, Python, or Go.

Ternary is searching for a Senior Full Stack Engineer to join their growing team. You'll play a key role in developing their industry-leading cloud cost management platform, helping businesses ...

Full Stack Java Developer

Creve Coeur, MO · On-site

$49.25 - $63.50/hr

The Full Stack Developer provides frontend and backend development support. The successful candidate will also provide best practices to design single-page architecture (SPA) applications and micro ...

We are seeking a visionary full stack engineer to join our technology transformation initiative. In ... Develop scalable APIs and microservices using Java Spring Boot, Python, Node. js and other modern ...

Full Stack Java Developer

Creve Coeur, MO · On-site

$49.25 - $63.50/hr

The Full Stack Developer provides frontend and backend development support. The successful candidate will also provide best practices to design single-page architecture (SPA) applications and micro ...

We are seeking a visionary full stack engineer to join our technology transformation initiative. In ... Develop scalable APIs and microservices using Java Spring Boot, Python, Node. js and other modern ...

Required Skill and Experience • Strong hands-on experience in Java Full Stack Development with expertise in Angular, building scalable, high-performance web applications. • Proficient in end-to ...

Showing results 21-40

Sr Python Full Stack Developer information

What are some common challenges Sr Python Full Stack Developers face when managing both backend and frontend tasks?

Sr Python Full Stack Developers often encounter the challenge of balancing deep backend logic—such as API development and database management—with the rapidly evolving landscape of frontend technologies. Staying up to date with best practices in both areas requires continuous learning and adaptation. Additionally, coordinating with UI/UX designers, DevOps engineers, and QA teams is crucial to ensure seamless integration and smooth product delivery. Effective time management and strong communication skills are key to overcoming these challenges and delivering reliable, well-integrated solutions.

What are the key skills and qualifications needed to thrive as a Sr Python Full Stack Developer?

To excel as a Sr Python Full Stack Developer, you need advanced proficiency in Python, web frameworks like Django or Flask, front-end technologies (JavaScript, React or Angular), and a solid understanding of databases, typically backed by a bachelor's degree in computer science or a related field. Familiarity with version control systems like Git, cloud platforms (AWS, Azure), and containerization tools such as Docker is commonly expected, along with relevant certifications. Strong problem-solving abilities, effective communication, and the ability to collaborate in agile teams distinguish top performers in this role. These skills ensure delivery of robust, scalable applications and seamless integration across the technology stack, meeting both business and user needs efficiently.

What is a Sr Python Full Stack Developer?

A Sr Python Full Stack Developer is an experienced software engineer who is proficient in both front-end and back-end development using Python and related technologies. They are responsible for designing, developing, and maintaining web applications, often handling both client-side and server-side logic. This role requires expertise in frameworks like Django or Flask for the backend, and familiarity with front-end technologies such as JavaScript, HTML, and CSS. Senior developers also mentor junior team members, participate in architectural decisions, and ensure best practices in coding and deployment.
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What job categories do people searching Sr Python Full Stack Developer jobs in Missouri look for? The top searched job categories for Sr Python Full Stack Developer jobs in Missouri are:
What cities in Missouri are hiring for Sr Python Full Stack Developer jobs? Cities in Missouri with the most Sr Python Full Stack Developer job openings:
Infographic showing various Sr Python Full Stack Developer job openings in Missouri as of August 2026, with employment types broken down into 2% Internship, 90% Full Time, 2% Part Time, and 6% Contract. Highlights an 80% Physical, 6% Hybrid, and 14% Remote job distribution.

Senior/Staff Full Stack Engineer

6AM City, LLC

California, MO • On-site

$175 - $270/hr

Other

Posted 3 days ago

New


Job description

Job Description

Job Description

Career Renew is recruiting for one of its clients a Senior/Staff Full Stack Engineer - this is an onsite role in San Francisco. Salary range: 175-270K USD base plus benefits plus equity.

The scientific decision engine for R&D. Raw data defensible decisions, faster.

Pharma and biotech R&D often spend weeks, or even months, learning, coding, and troubleshooting discovery analysis pipelines. This slows research and diverts focus from the work that truly matters: discovery.

We change that. Using only natural language from the user, our AI builds custom workflows with full transparency and reproducibility for discovery data (omics and beyond), on-demand and in minutes, not weeks. Discovery researchers across therapeutic areas can instantly align, analyze, interpret, integrate, and iterate hypotheses for complex datasets without manual coding or repetitive setup.

By automating these time-consuming processes, we empower scientists to spend more time designing experiments, testing insights, and driving high-quality discoveries, including novel IP. From accelerating data analysis to uncovering novel targets and biomarkers, we are the Scientific Decision Engine that turns data into actionable breakthroughs.

We're looking for a Senior/Staff Full Stack Engineer with 4+ YOE to join our Engineering team. We need a builder who is excited to create foundational systems and have meaningful influence on our technology as we work to accelerate drug discovery and improve human health globally. This is a top priority hire driven by our hypergrowth and the need to scale our core product to meet surging enterprise demand.

Responsibilities
  • Build new product features and systems from scratch across frontend and backend, directly expanding Mithril's platform capabilities for world-class researchers

  • Design, build, and own scalable backend services, APIs, and data pipelines that power the Mithril AI platform across the application, identity, data storage, and ML layers

  • Work within fast-moving sprint cycles to ship code quickly, contributing to production within your first few weeks

  • Collaborate with a cross-functional team of engineers, product managers, designers, and AI scientists to translate complex scientific workflows into intuitive, high-performance software

  • Own features end-to-end from early development through production deployment, iteration, and scale — ensuring they deliver real value to researchers at leading pharma and biotech organizations

Requirements
  • 4+ years of experience in professional full-stack or backend engineering (not including internships) (Mandatory)
  • Built products at early-stage or high-growth startups, preferably as a founder or early employee (Mandatory)
  • Experience shipping and owning production systems used by real customers (Mandatory)
  • Experience designing and working with scalable systems, databases, and data-intensive applications. (Mandatory)
  • BS in Computer Science, STEM, or related technical skill (Mandatory)
  • Strong proficiency in modern frameworks, like Python and React (Mandatory)
  • Experience building backend services and REST APIs, with Django as a plus (Mandatory)
  • Familiarity with GraphQL and cloud infrastructure, like AWS (Nice-to-have)
  • Intellectually curious and excited to learn – ask questions and engage deeply with the product and problem space (Mandatory)
  • Positive and collaborative with the energy to thrive in a high-communication, in-person team culture. (Mandatory)
  • Demonstrated interest in life sciences, drug discovery, or computational biology (Nice-to-have)
Why candidates should join

Why us?

  • Real impact: Our platform is used daily by world-class researchers at J&J, Roche, Eli Lilly, AstraZeneca, and Siemens compressing months of drug discovery into minutes.
  • Hypergrowth: 12x YoY revenue growth; $0 to $2M in year one, on track to blow past $10M this year — three enterprise deals closed in a single week
  • Strong funding: Series A (~$100M valuation) led by Obvious Ventures, a deep tech and biotech specialist fund; stealth only share details on call (not written)
  • Proprietary moat: The biological knowledge graph is core
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