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Sr Python Engineer Jobs in Indianapolis, IN (NOW HIRING)

Senior Electrical Engineer

Indianapolis, IN ยท On-site

$102K - $133K/yr

Overview As a Senior Electrical Engineer at Glassboard, you will be responsible for the design ... Python, and C a plus - Familiar with IDEs such as Visual Studio Code, Eclipse, Keil, IAR, etc ...

Senior Electrical Engineer

Indianapolis, IN ยท On-site

$102K - $133K/yr

Overview As a Senior Electrical Engineer at Glassboard, you will be responsible for the design ... Python, and C a plus - Familiar with IDEs such as Visual Studio Code, Eclipse, Keil, IAR, etc ...

Senior Embedded Firmware Engineer

Indianapolis, IN ยท On-site

$98K - $134K/yr

V2X is seeking a talented Senior Embedded Firmware Engineer (T03) to join our Embedded Solutions ... Design, implement, and validate embedded firmware/software solutions using C (and Python ...

Senior Embedded Firmware Engineer

Indianapolis, IN ยท On-site

$98K - $134K/yr

V2X is seeking a talented Senior Embedded Firmware Engineer (T03) to join our Embedded Solutions ... Design, implement, and validate embedded firmware/software solutions using C (and Python ...

We're hiring an Sr. Network Reliability Engineer who embodies Innovation and Excellence, and will ... Use Terraform (or Pulumi), Ansible, and Python to replace CLI-driven configuration with declarative ...

New

Senior DevOps Engineer

Indianapolis, IN ยท On-site

$85K - $152K/yr

Description We are looking for a Senior DevOps Engineer to design, automate, and optimize ... Proficiency with scripting and automation technologies such as Powershell, Python, Bash, and ...

Posted today

Senior Automation Engineer

Carmel, IN ยท On-site

$120 - $150/hr

Senior Automation Engineer - Carmel, IN (Hybrid) We are seeking a highly skilled and motivated ... Experience with SQL, Python, or other scripting languages for data handling. * Knowledge of ...

New

Senior Embedded Firmware Engineer (T03)

Indianapolis, IN ยท On-site

$98K - $134K/yr

V2X is seeking a talented Senior Embedded Firmware Engineer (T03) to join our Embedded Solutions ... Design, implement, and validate embedded firmware/software solutions using C (and Python ...

Senior Embedded Firmware Engineer (T03)

Indianapolis, IN ยท On-site

$98K - $134K/yr

V2X is seeking a talented Senior Embedded Firmware Engineer (T03) to join our Embedded Solutions ... Design, implement, and validate embedded firmware/software solutions using C (and Python ...

Senior Firmware Engineer

Indianapolis, IN ยท On-site

$114K - $151K/yr

Senior Firmware Engineer Allegion is seeking a skilled and passionate Senior Firmware Engineer to ... Proficiency in Python and C with strong analytical skills to debug, troubleshoot, and isolate ...

Senior Firmware Engineer

Indianapolis, IN ยท On-site

$114K - $151K/yr

Senior Firmware Engineer Allegion is seeking a skilled and passionate Senior Firmware Engineer to ... Proficiency in Python and C with strong analytical skills to debug, troubleshoot, and isolate ...

Senior Firmware Engineer

Indianapolis, IN ยท On-site

$114K - $151K/yr

Senior Firmware Engineer Allegion is seeking a skilled and passionate Senior Firmware Engineer to ... Proficiency in Python and C with strong analytical skills to debug, troubleshoot, and isolate ...

Showing results 41-60

Sr Python Engineer information

See Indianapolis, IN salary details

$22K

$133.8K

$193.6K

How much do sr python engineer jobs pay per year?

As of Aug 19, 2026, the average yearly pay for sr python engineer in Indianapolis, IN is $133,794.00, according to ZipRecruiter salary data. Most workers in this role earn between $105,600.00 and $157,200.00 per year, depending on experience, location, and employer.

What does a Sr Python Engineer do?

A Sr Python Engineer is an experienced software developer who specializes in designing, developing, and maintaining applications using the Python programming language. They often lead projects, mentor junior engineers, and work on complex problems that require deep technical expertise. Their responsibilities may include writing efficient code, optimizing performance, integrating with APIs or databases, and ensuring the overall quality of software solutions. Additionally, they may collaborate with cross-functional teams to deliver robust and scalable applications.

What are the key skills and qualifications needed to thrive as a Sr Python Engineer?

To thrive as a Sr Python Engineer, you need advanced proficiency in Python programming, strong knowledge of software design patterns, and experience with scalable application development, often supported by a degree in computer science or related field. Familiarity with frameworks like Django or Flask, version control systems such as Git, and cloud platforms like AWS or Azure is typically required, with certifications in cloud or Python development considered a plus. Excellent problem-solving abilities, strong communication, and leadership skills help you collaborate effectively and mentor junior engineers. These competencies are critical for delivering robust, efficient solutions and driving technical excellence within development teams.

What are some common challenges Sr Python Engineers face when working on large-scale applications?

Sr Python Engineers often encounter challenges related to maintaining code quality and scalability as applications grow. Managing dependencies, ensuring optimal performance, and coordinating with cross-functional teams can be complex, especially in distributed systems. Additionally, integrating new technologies or frameworks while maintaining backward compatibility requires careful planning and communication. Proactive code reviews, clear documentation, and collaborative problem-solving are essential to overcoming these challenges.

What is the difference between Sr Python Engineer vs Python Developer?

AspectSr Python EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in Python, often some leadership skillsBachelor's degree in CS or related field, strong Python skills, often less emphasis on leadership
Work EnvironmentTeam lead, project architect, involved in system design and optimizationCode writing, feature development, bug fixing
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects

While both roles require strong Python skills, Sr Python Engineers typically have more experience, leadership responsibilities, and involvement in system architecture, whereas Python Developers focus more on coding and feature implementation.

What are popular job titles related to Sr Python Engineer jobs in Indianapolis, IN?

For Sr Python Engineer jobs in Indianapolis, IN, the most frequently searched job titles are:

What job categories do people searching Sr Python Engineer jobs in Indianapolis, IN look for?

The top searched job categories for Sr Python Engineer jobs in Indianapolis, IN are:

Infographic showing various Sr Python Engineer job openings in Indianapolis, IN as of August 2026, with employment types broken down into 89% Full Time, 6% Part Time, and 5% Contract. Highlights an 85% Physical, 5% Hybrid, and 10% Remote job distribution, with an average salary of $133,794 per year, or $64.3 per hour.

Senior Software Engineer for Medical Device Startup

Levisonics Inc

Fishers, IN โ€ข On-site

$115K - $152K/yr

Full-time

Medical, Dental, Vision, PTO

Re-posted 10 days ago


Job description

About Us: 
We are a dynamic and innovative medical device startup developing a point-of-care portable blood coagulation testing device. Our full-time team currently comprises a CEO/Biomedical Engineer, and an Electrical Engineer. 

Job Summary: 
We are seeking a talented and experienced Senior Software Engineer to join our team and lead the development and optimization of software workflows for our innovative acoustic tweezing technology-based medical devices. The ideal candidate will have a Master's degree in Computer Science, Software Engineering, or a related field, with a minimum of 5 years of experience. This role requires strong coding skills in Python and C/C++, proficiency in developing intuitive and visually engaging graphical user interfaces, and expertise in SQL for effective data management and database design. Experience with version control systems, particularly Git, is essential, along with the ability to understand and generate code from workflow diagrams. As the first and only software engineer on the team, you will play a pivotal role in shaping the software development efforts for our groundbreaking technology. This role is critical to the success of our product and involves working on multiple federal grants and projects. 

Startup Environment: 
We operate in a fast-paced startup environment where innovation, adaptability, and a proactive mindset are key to success. We are looking for individuals who are passionate about working in a startup setting and thrive in dynamic and challenging situations. We value individuals who are not just seeking a job but are driven by a genuine passion for creating impactful solutions and driving change in the medical device industry. Our team members are expected to work well under pressure, juggle multiple projects, and be flexible in their roles as the needs of the company evolve. If you are excited about the opportunity to make a meaningful impact and are ready to roll up your sleeves and tackle challenges head-on, we encourage you to apply. 

Key Responsibilities: 

  1. Optimize and Enhance Existing Software: 

  • Improve the efficiency of our existing software written in Python. 

  • Increase processing speed for short-term operation on laptops. 

  • Convert and optimize the software for embedded computing devices inside the medical device long-term. 

  1. Software Packaging and Security: 

  • Secure the code to prevent reverse engineering. 

  • Package the software into executable files for easy installation and deployment. 

  1. Connectivity and Data Management: 

  • Ensure the software can connect to the internet. 

  • Implement connectivity to an online database for long-term data management. 

  • Incorporate Data Science, Machine Learning, and AI for handling large amounts of health data. 

  1. Health Data Security: 

  • Ensure the highest level of security for software and health data management. 

  1. New Technique Development: 

  • Convert and develop existing crude MATLAB codes and technology algorithms into efficient software for commercial use. 

  • Create executable files with efficient large data handling capabilities. 

  • Develop complex data processing software and manage large data analysis. 

  • Develop a user-friendly interface for healthcare professionals. 

  • Implement a remote kill switch for the software. 

  • Apply all relevant requirements from existing software. 

  1. Parallel Processing and Language Conversion: 

  • Implement efficient parallel processing techniques. 

  • Convert existing Python code to C/C++ or another suitable low-level efficient language to run software optimally on embedded hardware. 

  1. Other Responsibilities: 

  • Develop high-quality, efficient, and maintainable code. 

  • Design intuitive and visually engaging user interfaces. 

  • Proactively take on new responsibilities and suggest innovative ideas for product and company growth. 

  • Participate in grant writing and fundraising activities. 

  • Engage in FDA-related activities and adhere to quality protocols. 

  • Perform other relevant software-related tasks as needed for the company. 

Minimum Qualifications: 

  • Master’s degree in Computer Science, Software Engineering, or a related field. 

  • Minimum of 5 years of experience in software development. 

  • Strong coding skills in Python, C, and C++ (JavaScript is a plus). 

  • Proficiency in developing intuitive and visually engaging graphical user interfaces. 

  • Proficiency in SQL for effective data management and database design. 

  • Experience with version control systems, particularly Git. 

  • Ability to understand and generate code from workflow diagrams. 

  • Knowledge of integrating multiple devices and establishing centralized control. 

  • Familiarity with IDEs, preferably PyCharm. 

  • Excellent problem-solving skills and ability to work independently. 

  • Strong written and verbal communication skills. 

Preferred Qualifications: 

  • Experience working in the medical device industry. 

  • Familiarity with Agile development methodologies. 

  • Knowledge of machine learning techniques and algorithms. 

  • Experience with Docker and containerization technologies. 

  • Familiarity with cloud platforms such as AWS or Azure. 

  • Prior experience working in startups. 

  • Experience with embedded systems and medical device software development. 

  • Strong knowledge of data security, especially related to health data. 

  • Knowledge of parallel processing and algorithm optimization. 

  • Innovative mindset with a track record of proactive contributions. 

  • Experience in grant writing and regulatory compliance (FDA). 

What We Offer: 

  • Competitive salary 

  • Health, dental, and vision insurance coverage 

  • Generous paid time off 

  • Professional development opportunities 

  • Potential to receive stock options 

  • Opportunities for growth within the company 

  • Flexible work arrangements, including remote work options 

  • Dynamic and innovative startup environment 

  • Opportunity to make a meaningful impact in the medical device industry 

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