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Sr Python Engineer Jobs in Indianapolis, IN (NOW HIRING)

Clera

Senior Integrations Engineer

Indianapolis, IN · On-site

$130K - $160K/yr

... is a senior individual contributor role on a small, high-velocity Series A engineering team ... Proficiency in at least one modern backend language -- Python, Java, Go, or Rust; hands-on Python ...

New

CMP.jobs

Sr DevOps Engineer

Indianapolis, IN · Remote

$123K - $158K/yr

Sr. DevOps Engineer 100% Remote Position We have built a cloud-based policy administration platform ... or Python ● Professional experience with AWS / Azure / GCP (Google Cloud is preferred) ● ...

CMP.jobs

Sr. Kotlin Engineer

Indianapolis, IN · Remote

The Sr. Software Engineer will be responsible for a good portion of development working with ... Some additional languages used includes JavaScript and Python. Must Have: + Experience creating ...

Wolters Kluwer

Senior DevOps Engineer

Indianapolis, IN · On-site

$124K - $159K/yr

As a Senior DevOps Engin eer , you will be a key technical contributor responsible for designing ... Strong background in software development, with experience in languages such as Python, .NET, or ...

Wolters Kluwer

Senior DevOps Engineer

Indianapolis, IN · On-site

$124K - $159K/yr

As a Senior DevOps Engin eer , you will be a key technical contributor responsible for designing ... Strong background in software development, with experience in languages such as Python, .NET, or ...

Wolters Kluwer

Senior DevOps Engineer

Indianapolis, IN · On-site

$124K - $159K/yr

As a Senior DevOps Engin eer , you will be a key technical contributor responsible for designing ... Strong background in software development, with experience in languages such as Python, .NET, or ...

Allison Transmission

Senior System Engineer

Indianapolis, IN · On-site

$99K - $136K/yr

Strong experience with automation, scripting, and/orIaCtools such as PowerShell, Python, Terraform ... Serves as a mentor and senior escalation resource within the engineering team. Supports global ...

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Showing results 21-40

All JobsSr Python Engineer JobsSr Python Engineer Jobs in Indianapolis, IN

Sr Python Engineer information

See Indianapolis, IN salary details

$22K

$133.8K

$193.6K

How much do sr python engineer jobs pay per year?

As of Aug 20, 2026, the average yearly pay for sr python engineer in Indianapolis, IN is $133,794.00, according to ZipRecruiter salary data. Most workers in this role earn between $105,600.00 and $157,200.00 per year, depending on experience, location, and employer.

What does a Sr Python Engineer do?

A Sr Python Engineer is an experienced software developer who specializes in designing, developing, and maintaining applications using the Python programming language. They often lead projects, mentor junior engineers, and work on complex problems that require deep technical expertise. Their responsibilities may include writing efficient code, optimizing performance, integrating with APIs or databases, and ensuring the overall quality of software solutions. Additionally, they may collaborate with cross-functional teams to deliver robust and scalable applications.

What are the key skills and qualifications needed to thrive as a Sr Python Engineer?

To thrive as a Sr Python Engineer, you need advanced proficiency in Python programming, strong knowledge of software design patterns, and experience with scalable application development, often supported by a degree in computer science or related field. Familiarity with frameworks like Django or Flask, version control systems such as Git, and cloud platforms like AWS or Azure is typically required, with certifications in cloud or Python development considered a plus. Excellent problem-solving abilities, strong communication, and leadership skills help you collaborate effectively and mentor junior engineers. These competencies are critical for delivering robust, efficient solutions and driving technical excellence within development teams.

What are some common challenges Sr Python Engineers face when working on large-scale applications?

Sr Python Engineers often encounter challenges related to maintaining code quality and scalability as applications grow. Managing dependencies, ensuring optimal performance, and coordinating with cross-functional teams can be complex, especially in distributed systems. Additionally, integrating new technologies or frameworks while maintaining backward compatibility requires careful planning and communication. Proactive code reviews, clear documentation, and collaborative problem-solving are essential to overcoming these challenges.

What is the difference between Sr Python Engineer vs Python Developer?

AspectSr Python EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in Python, often some leadership skillsBachelor's degree in CS or related field, strong Python skills, often less emphasis on leadership
Work EnvironmentTeam lead, project architect, involved in system design and optimizationCode writing, feature development, bug fixing
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects

While both roles require strong Python skills, Sr Python Engineers typically have more experience, leadership responsibilities, and involvement in system architecture, whereas Python Developers focus more on coding and feature implementation.

What are popular job titles related to Sr Python Engineer jobs in Indianapolis, IN?

For Sr Python Engineer jobs in Indianapolis, IN, the most frequently searched job titles are:

What job categories do people searching Sr Python Engineer jobs in Indianapolis, IN look for?

The top searched job categories for Sr Python Engineer jobs in Indianapolis, IN are:

Sr Python Engineer jobs near you
Infographic showing various Sr Python Engineer job openings in Indianapolis, IN as of August 2026, with employment types broken down into 89% Full Time, 6% Part Time, and 5% Contract. Highlights an 85% Physical, 5% Hybrid, and 10% Remote job distribution, with an average salary of $133,794 per year, or $64.3 per hour.

Senior Integrations Engineer

Clera

Indianapolis, IN • On-site

$130K - $160K/yr

Full-time

Posted yesterday

New

Job description

About the Role

This is a senior individual contributor role on a small, high-velocity Series A engineering team building a logistics orchestration and decision-intelligence platform for cold-chain shippers and carriers in the pharma and perishables industries. You'll own the data-heavy distributed systems that ingest IoT monitoring data, contextualize it in real time, and quantify shipment risk — work that directly prevents product loss across critical supply chains.

What You'll Do

  • Design and build backend services powering a cold-chain logistics orchestration and risk-management platform.

  • Own distributed systems that ingest, process, and contextualize IoT monitoring data at scale.

  • Build predictive systems for on-time, in-full (OTIF) performance and automate exception-handling workflows.

  • Integrate with partner-facing operational data sources including webhooks, message queues, and carrier/sensor/vendor APIs.

  • Collaborate closely with leadership and cross-functional stakeholders to influence architecture and product direction.

  • Uphold strong engineering practices: testing, CI/CD, monitoring, and observability across all services.

What We're Looking For

  • 5–15 years of backend engineering experience building scalable, data-intensive distributed systems.

  • Proficiency in at least one modern backend language — Python, Java, Go, or Rust; hands-on Python and/or Java strongly preferred.

  • Experience with IoT data ingestion, processing, and contextualization.

  • Solid grounding in relational databases (SQL), data modeling, and ETL pipelines; NoSQL experience is a plus.

  • Experience designing event-driven architectures and working with messaging systems such as Kafka or RabbitMQ.

  • Hands-on experience with Docker and Kubernetes for containerization and orchestration.

  • Experience deploying and operating services on AWS, GCP, or Azure.

  • Strong API design skills (REST and/or gRPC).

  • Familiarity with data security, privacy, and regulatory considerations relevant to pharma or cold-chain domains.

  • Domain knowledge in logistics, supply chain, cold chain, or shipment risk (e.g., OTIF) is a meaningful plus.

  • Genuine interest in operating at a growth-stage startup — comfortable shipping fast and working with high ownership on a small team.

Compensation & Benefits

  • Base salary: $130,000–$160,000 USD annually

  • Equity and cash bonus included

  • Visa sponsorship available for eligible candidates

Location

Fully remote, US-based. All candidates must be able to work US-aligned hours.