Using mouse models, and state-of-the art cancer genomics, single-cell multi-omics, spatial transcriptomics, high-throughput drug and CRISPR/cas9 screens, as well as proton therapy and experimental ...
Using mouse models, and state-of-the art cancer genomics, single-cell multi-omics, spatial transcriptomics, high-throughput drug and CRISPR/cas9 screens, as well as proton therapy and experimental ...
Research Scientist
Cleveland, OH · On-site
... spatial transcriptomics), and cell culture techniques (including mouse primary culture and human iPSC/ESC), and imaging techniques (confocal, two photon, implanted mini-microscope). The Research ...
Research Scientist
Cleveland, OH · On-site
... spatial transcriptomics), and cell culture techniques (including mouse primary culture and human iPSC/ESC), and imaging techniques (confocal, two photon, implanted mini-microscope). The Research ...
Spatial Transcriptomics information
What is spatial transcriptomics?
Spatial transcriptomics is an advanced technique that allows scientists to measure gene expression within the spatial context of tissue samples. Unlike traditional RNA sequencing, which loses information about where each gene is expressed, spatial transcriptomics preserves the physical location of gene activity in tissues. This helps researchers better understand how cells function within their native environments and interact with neighboring cells, which is especially valuable in fields like cancer research, neuroscience, and developmental biology. The method combines microscopy, molecular biology, and computational analysis to produce detailed maps of gene expression.
What are some common challenges faced by professionals working in spatial transcriptomics, and how can they be addressed?
Professionals in spatial transcriptomics often encounter challenges related to handling large, complex datasets and integrating spatial information with gene expression data. Ensuring high-quality sample preparation and mastering advanced imaging or sequencing technologies are also frequent hurdles. These challenges can be addressed by collaborating closely with multidisciplinary teams—including bioinformaticians, molecular biologists, and imaging specialists—and staying up-to-date with the latest software tools and protocols. Continuous learning and effective communication within the team are key to overcoming technical and analytical obstacles in this rapidly evolving field.
What are the key skills and qualifications needed to thrive as a spatial transcriptomics scientist?
To thrive as a Spatial Transcriptomics Scientist, you need a strong background in molecular biology, genomics, and bioinformatics, typically supported by an advanced degree in a life science field. Familiarity with spatial transcriptomics platforms (such as 10x Genomics Visium), next-generation sequencing (NGS) technologies, and data analysis tools like R or Python is essential. Strong problem-solving skills, attention to detail, and effective communication are important soft skills for collaborating on interdisciplinary research projects. These skills and qualities are crucial for generating high-quality spatial gene expression data and translating findings into meaningful biological insights.
What are popular job titles related to Spatial Transcriptomics jobs in Ohio? For Spatial Transcriptomics jobs in Ohio, the most frequently searched job titles are:
What job categories do people searching Spatial Transcriptomics jobs in Ohio look for? The top searched job categories for Spatial Transcriptomics jobs in Ohio are:
What cities in Ohio are hiring for Spatial Transcriptomics jobs? Cities in Ohio with the most Spatial Transcriptomics job openings:
Postdoctoral Research Fellow/Associate - Brain Tumorigenesis
Cincinnati, OH
Full-time
Medical, Dental, Vision, Retirement, PTO
Re-posted 20 days ago
Cincinnati Children's Hospital Medical Center rating
7.3
Based on 150 frontline employees who took The Breakroom Quiz
383rd of 1,054 rated hospitals
Job description
Description:
Expected Starting Salary Range: - Research Fellow salaries align with the NIH extramural payscales. Research Associate salary is commensurate with relevant experience
The Lu lab has an opening for self-motivated individuals interested in a postdoctoral position doing cutting-edge research on brain tumorigenesis, tumor immunology, immunotherapy, and cancer neuroscience. Using mouse models, and state-of-the art cancer genomics, single-cell multi-omics, spatial transcriptomics, high-throughput drug and CRISPR/cas9 screens, as well as proton therapy and experimental therapeutics, our investigations delve into both cancer cell intrinsic and extrinsic mechanisms, exploring crucial factors such as oncogenic networks, tumor microenvironment, and immune cells that influence tumor formation, recurrence, and metastasis. Our research has been published in prestigious journals, including Nature (Luo, et al., 2022), Nature Cell Biology (Hu, X., 2022), and Nature Communications (Luo et al., 2023), among others.
MAJOR DUTIES AND RESPONSIBILITIES:
• Design, execute, and record laboratory experiments, and analyze the data.
• Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department.
• Present research at laboratory meetings, journal clubs, seminars, and meetings.
• Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
• Maintain currency in field through continuing education, literature, and seminars.
• Attend required Cincinnati Children’s training sessions and ensure regulatory compliance with all policies and procedures.
• Perform other duties as assigned.
Cincinnati Children’s Research and Training at a Glance
- Among the top in NIH funding for pediatric research institutions
- Over 1.4 million square feet of research laboratory space
- 900+ scientists conducting basic, translational, and clinical research
- Over 2000 publications annually in top-tier journals
- Access to Employee Resource Groups and Mentorship programs
- Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.
Learn more about the Postdoctoral Fellowship Program.
Compensation and Benefits
- Postdoctoral Research Fellows and Associates are eligible for:
- Group Health, Dental, and Vision Insurance Plans
- Paid Time Off
- Retirement Plan
- Tuition Reimbursement
- Relocation Benefits for Eligible Hires
Learn how Cincinnati Children's is building a diverse workforce!
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EDUCATION/EXPERIENCE
For Research Fellow:
REQUIRED
• Ph.D. in related discipline, MD, or equivalent required.
For Research Associate:
REQUIRED
• PhD
• 3 - 5 years of work experience in a related job discipline
Candidates who have recently obtained a PhD or MD and possess a strong background in one or more of the following areas are encouraged to apply: molecular and cellular biology, neurobiology, cancer biology, and computational biology. Join us in our mission to advance the understanding and treatment of brain tumors and make a lasting impact on the lives of patients and their families.
REQUIRED SKILLS: Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.
Cincinnati Children’s is proud to be an Equal Opportunity Employer that values and treasures Diversity, Equity, and Inclusion. We are committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/AA/M/F/Veteran/Disability
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About Cincinnati Children's Hospital Medical Center
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Cincinnati Children's Hospital Medical Center, located in Cincinnati, OH, US, is a premier pediatric hospital renowned for its exceptional clinical services, research programs, and medical education. The healthcare institution, founded in 1883, holds a sterling reputation in the industry, with a mission to improve child health and transform delivery of care through fully integrated, globally recognized research, education and innovation. As one of the oldest and most distinguished pediatric hospitals in the United States, Cincinnati Children's continues to offer a broad range of high-quality, compassionate care to children in the community and around the globe. As a testament to its dedication, it has consistently been ranked among the top three US pediatric hospitals by U.S. News & World Report.
Industry
Hospitals
Company size
10,000+ Employees
Headquarters location
Cincinnati, OH, US
Year founded
1883