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Spatial Transcriptomics Omics Jobs in California

Computational Biologist

San Francisco, CA ยท On-site

$125K - $185K/yr

Analyze multi-modal omics data. Apply cutting-edge techniques, including scRNAseq, spatial transcriptomics, and long-read sequencing, to derive meaningful insights from complex patient datasets.

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Spatial Transcriptomics Omics information

What are the key skills and qualifications needed to thrive as a spatial transcriptomics specialist?

To thrive as a Spatial Transcriptomics Specialist, you need a strong background in molecular biology, genomics, and bioinformatics, typically supported by an advanced degree in a relevant field. Familiarity with high-throughput sequencing platforms, spatial omics technologies, and data analysis tools like R or Python is essential, along with experience using laboratory automation systems. Attention to detail, problem-solving abilities, and effective interdisciplinary communication are crucial soft skills for this role. These skills ensure accurate experimental design, robust data interpretation, and successful collaboration in cutting-edge biological research.

What is the difference between Spatial Transcriptomics Omics vs Spatial Transcriptomics Technician?

AspectSpatial Transcriptomics OmicsSpatial Transcriptomics Technician
Required CredentialsAdvanced degrees (Master's/PhD) in molecular biology, genomics, or related fieldsAssociate's or Bachelor's degree in biology, biotechnology, or related fields
Work EnvironmentResearch labs, biotech companies, academic institutionsLaboratories, research facilities, biotech companies
Industry UsageResearch and development, data analysis, method developmentSample preparation, data collection, equipment operation

Spatial Transcriptomics Omics professionals focus on data analysis, method development, and research, often requiring advanced degrees. In contrast, Spatial Transcriptomics Technicians handle sample preparation and operate equipment, typically with a technical diploma or bachelor's degree. Both roles are essential in the spatial transcriptomics industry but differ in responsibilities and qualifications.

What are some common challenges faced by professionals in spatial transcriptomics omics, and how can they be addressed?

Professionals working in Spatial Transcriptomics Omics often encounter challenges such as managing and interpreting large, complex datasets, integrating multi-omics data, and keeping pace with rapidly evolving technologies. Effective collaboration with bioinformaticians, pathologists, and laboratory technicians is essential to ensure high-quality results. Staying updated with the latest analytical tools and participating in cross-disciplinary training can help overcome these challenges and enhance both research quality and career growth.

What is spatial transcriptomics in omics research?

Spatial transcriptomics is a cutting-edge technology in the field of omics that allows researchers to measure and map gene expression within the spatial context of intact tissue sections. This means scientists can see which genes are active in specific locations of a tissue, preserving the spatial relationships between cells. By combining spatial information with transcriptomic data, researchers gain deeper insights into tissue organization, cellular interactions, and disease mechanisms. This approach is especially valuable for understanding complex tissues like tumors or brain structures.
What are popular job titles related to Spatial Transcriptomics Omics jobs in California? For Spatial Transcriptomics Omics jobs in California, the most frequently searched job titles are:
What job categories do people searching Spatial Transcriptomics Omics jobs in California look for? The top searched job categories for Spatial Transcriptomics Omics jobs in California are:
What cities in California are hiring for Spatial Transcriptomics Omics jobs? Cities in California with the most Spatial Transcriptomics Omics job openings:
Infographic showing various Spatial Transcriptomics Omics job openings in California as of July 2026, with employment types broken down into 1% Internship, 2% As Needed, 85% Full Time, 6% Part Time, 2% Contract, and 4% Nights. Highlights an 82% Physical, 2% Hybrid, and 16% Remote job distribution.

Principal Scientist, Bioinformatics

Nkarta, Inc.

South San Francisco, CA โ€ข Hybrid

Other

Re-posted 21 days ago


Job description

Overview

Nkarta is seeking a highly motivated, collaborative, detail-oriented Principal Scientist to join our Translational Medicine team. This is a high-impact, hands-on leadership role for a senior bioinformatics scientist. The successful candidate will have deep expertise in single-cell and spatial omics technologies, along with experience in functional genomics and leading computational biology and/or bioinformatics programs in a biotech or pharmaceutical setting.

This individual will work collaboratively within Translational Medicine and cross-functionally to advance, support, and execute biomarker discovery, mechanism-of-action (MOA) investigations, and translational data analysis from clinical samples. A central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development.

Responsibilities

  • Lead and actively participate in the design and execution of computational strategies and hands-on analysis of clinical and biological datasets to support go/no-go decisions
  • Hands-on development and application of computational methods for single-cell and spatial transcriptomics to generate actionable translational insights from clinical samples
  • Establish scalable pipelines for multi-modal data integration across programs
  • Integrate and analyze functional genomics datasets (e.g., bulk RNA-seq) to generate mechanistic insights that inform translational and clinical strategies
  • Provide high-impact analyses with direct influence on clinical decision-making and visibility to senior leadership
  • Collaborate with senior leadership to define priorities, allocate resouces, and establish timelines aligned with company objectives
  • Partner with experimental scientists to design studies leveraging advanced omics approaches and interpret results
  • Ensure reproducibility, scalability, and data quality across bioinformatics pipelines
  • Communicate complex findings effectively to scientific and non-scientific stakeholders, including senior leadership

Qualifications

  • Deep expertise in single-cell and spatial transcriptomics analysis, including scRNA-seq and related high-dimensional omics datasets
  • Strong experience analyzing functional genomics and transcriptomic data (e.g., bulk RNA-seq, WES) to derive biological and translational insights
  • Strong foundation in biological sciences, with experience or interest in immunology and disease biology
  • Deep understanding of modern statistical and computational methods for high-dimensional data analysis
  • Proficiency in Python and/or R, with experience using relevant bioinformatics frameworks
  • Experience developing and maintaining scalable data analysis pipelines and working with cloud-based infrastructure (e.g., AWS)
  • Excellent communication and presentation skills, with the ability to influence cross-functional stakeholders and translate complex data into clear, actionable insights
  • Demonstrated experience managing external CROs and bioinformatics vendors
  • Proven leadership experience, including mentoring and developing scientific teams
  • Strong cross-functional collaboration skills and ability to translate computational insights into biological and clinical impact
  • Ability to work both independently and collaboratively in a fast-paced environment, with strong organizational skills and attention to detail

Education/Background

  • PhD in Biological Sciences, Computational Biology, Biostatistics, Bioinformatics, Genomics, or a closely related discipline with 5+ years of industry experience.

The common requirements of an office environment (computers, computer screens, workstations, etc.) apply. This role is based in the South San Francisco office, with hybrid work arrangements possible.