... Small Molecule This is a fully onsite role based at our Greenfield, IN Laboratory. We welcome applicants from all locations within the US. We welcome applicants from all locations within the US.
... Small Molecule This is a fully onsite role based at our Greenfield, IN Laboratory. We welcome applicants from all locations within the US. We welcome applicants from all locations within the US.
Senior Small Molecule Manufacturing Subject Matter Expert (SME) with focus within either of these disciplines: Small Molecule Validation/Scale-Up Engineering Small Molecule Process/Product ...
Quick apply
Senior Small Molecule Manufacturing Subject Matter Expert (SME) with focus within either of these disciplines: Small Molecule Validation/Scale-Up Engineering Small Molecule Process/Product ...
Senior Small Molecule Manufacturing Subject Matter Expert
Bethesda, MD · On-site
$93K - $114K/yr
Senior Small Molecule Manufacturing Subject Matter Expert (SME) with focus within either of these disciplines: Small Molecule Validation/Scale-Up Engineering Small Molecule Process/Product ...
Senior Small Molecule Manufacturing Subject Matter Expert
Bethesda, MD · On-site
$93K - $114K/yr
Senior Small Molecule Manufacturing Subject Matter Expert (SME) with focus within either of these disciplines: Small Molecule Validation/Scale-Up Engineering Small Molecule Process/Product ...
Manager, Small Molecule
Greenfield, IN · On-site
... Small Molecule This is a fully onsite role based at our Greenfield, IN Laboratory. We welcome applicants from all locations within the US. We welcome applicants from all locations within the US.
Manager, Small Molecule
Greenfield, IN · On-site
... Small Molecule This is a fully onsite role based at our Greenfield, IN Laboratory. We welcome applicants from all locations within the US. We welcome applicants from all locations within the US.
Principal / Senior Principal Scientist, Small Molecule Therapeutics
Cambridge, MA · On-site
$156 - $246/hr
Your Impact at LILA We are seeking a Senior Principal Scientist, Small Molecule Therapeutics to lead the protein science and structural biology strategy supporting small molecule therapeutics across ...
Principal / Senior Principal Scientist, Small Molecule Therapeutics
Cambridge, MA · On-site
$156 - $246/hr
Your Impact at LILA We are seeking a Senior Principal Scientist, Small Molecule Therapeutics to lead the protein science and structural biology strategy supporting small molecule therapeutics across ...
The Associate Director, CMC Product Development - Small Molecule is a senior pharmaceutical scientist and individual contributor responsible for formulation development, drug product process ...
The Associate Director, CMC Product Development - Small Molecule is a senior pharmaceutical scientist and individual contributor responsible for formulation development, drug product process ...
Senior Small Molecule Regulatory Affairs & Compliance Subject Matter Expert Location: Remote (U.S.-based) with approximately 20-25% travel The Senior Small Molecule Regulatory Affairs & Compliance ...
Quick apply
Senior Small Molecule Regulatory Affairs & Compliance Subject Matter Expert Location: Remote (U.S.-based) with approximately 20-25% travel The Senior Small Molecule Regulatory Affairs & Compliance ...
Senior Small Molecule Regulatory Affairs & Compliance Subject Matter Expert Location: Remote (U.S.-based) with approximately 20-25% travel The Senior Small Molecule Regulatory Affairs & Compliance ...
Senior Small Molecule Regulatory Affairs & Compliance Subject Matter Expert Location: Remote (U.S.-based) with approximately 20-25% travel The Senior Small Molecule Regulatory Affairs & Compliance ...
Principal Scientist Analytical Development & Quality Control, Small Molecule
Redwood City, CA · On-site
As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with the Program Lead, CMC Lead, QA, and ...
Principal Scientist Analytical Development & Quality Control, Small Molecule
Redwood City, CA · On-site
As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with the Program Lead, CMC Lead, QA, and ...
Your Impact at LILA We are seeking a Senior Principal Scientist, Small Molecule Therapeutics to lead the protein science and structural biology strategy supporting small molecule therapeutics across ...
Your Impact at LILA We are seeking a Senior Principal Scientist, Small Molecule Therapeutics to lead the protein science and structural biology strategy supporting small molecule therapeutics across ...
As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with the Program Lead, CMC Lead, QA, and ...
Quick apply
As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with the Program Lead, CMC Lead, QA, and ...
Lead the protein science strategy for small molecule programs, ensuring timely delivery of high-quality protein reagents for screening, assay development, biophysics, crystallography, Cryo-EM, and ...
Lead the protein science strategy for small molecule programs, ensuring timely delivery of high-quality protein reagents for screening, assay development, biophysics, crystallography, Cryo-EM, and ...
Principal Scientist Analytical Development & Quality Control, Small Molecule
Redwood City, CA · On-site
As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with the Program Lead, CMC Lead, QA, and ...
Principal Scientist Analytical Development & Quality Control, Small Molecule
Redwood City, CA · On-site
As the primary AD/QC scientist for our small molecule program, you will lead the analytical strategy for drug substance and drug product, working closely with the Program Lead, CMC Lead, QA, and ...
Your Impact at LILA The Senior/Principal Scientist, Small Molecule Therapeutics will lead early hit identification efforts, leveraging their expertise in DNA-encoded libraries (DEL) and complementary ...
Your Impact at LILA The Senior/Principal Scientist, Small Molecule Therapeutics will lead early hit identification efforts, leveraging their expertise in DNA-encoded libraries (DEL) and complementary ...
Develop and validate LC-MS/MS, GC-MS, ICP-MS, HPLC methods for small molecule drugs or drug metabolites and biomarkers; * Draft study protocols/plans, acquisition methods, and study reports;
Develop and validate LC-MS/MS, GC-MS, ICP-MS, HPLC methods for small molecule drugs or drug metabolites and biomarkers; * Draft study protocols/plans, acquisition methods, and study reports;
Small Molecule Drug Substance Lead
King Of Prussia, PA · On-site
$149K - $248K/yr
Position Summary You will lead small molecule drug substance activities from lab development through clinical and commercial manufacturing readiness. You will work closely with teams in process ...
Small Molecule Drug Substance Lead
King Of Prussia, PA · On-site
$149K - $248K/yr
Position Summary You will lead small molecule drug substance activities from lab development through clinical and commercial manufacturing readiness. You will work closely with teams in process ...
Develop and validate LC-MS/MS, GC-MS, ICP-MS, HPLC methods for small molecule drugs or drug metabolites and biomarkers; * Draft study protocols/plans, acquisition methods, and study reports;
Develop and validate LC-MS/MS, GC-MS, ICP-MS, HPLC methods for small molecule drugs or drug metabolites and biomarkers; * Draft study protocols/plans, acquisition methods, and study reports;
Sr. Principal - Engineer - Automation (Small Molecule)
Houston, TX · On-site
$66 - $171.60/hr
## Sr. Principal - Engineer - Automation (Small Molecule)Applylocations: US, Houston TXtime type: Full timeposted on: Posted Todayjob requisition id: R-106853At Lilly, we unite caring with discovery ...
Sr. Principal - Engineer - Automation (Small Molecule)
Houston, TX · On-site
$66 - $171.60/hr
## Sr. Principal - Engineer - Automation (Small Molecule)Applylocations: US, Houston TXtime type: Full timeposted on: Posted Todayjob requisition id: R-106853At Lilly, we unite caring with discovery ...
Small Molecule Drug Substance Lead
Waltham, MA · On-site
$149K - $248K/yr
Position Summary You will lead small molecule drug substance activities from lab development through clinical and commercial manufacturing readiness. You will work closely with teams in process ...
Small Molecule Drug Substance Lead
Waltham, MA · On-site
$149K - $248K/yr
Position Summary You will lead small molecule drug substance activities from lab development through clinical and commercial manufacturing readiness. You will work closely with teams in process ...
Senior Director, Small Molecule Drug Product Manufacturing
Hopewell, VA · On-site
$180 - $280/hr
Provide strategic and operational leadership for all small molecule drug product manufacturing activities. * Ensure delivery of production schedules while maintaining safety, quality, and compliance ...
Senior Director, Small Molecule Drug Product Manufacturing
Hopewell, VA · On-site
$180 - $280/hr
Provide strategic and operational leadership for all small molecule drug product manufacturing activities. * Ensure delivery of production schedules while maintaining safety, quality, and compliance ...
Small Molecule information
See salary details
$22.60 - $26.46
1% of jobs
$26.46 - $30.33
5% of jobs
$30.33 - $34.20
6% of jobs
$37.99 is the 25th percentile. Wages below this are outliers.
$34.20 - $38.07
13% of jobs
$38.07 - $41.94
17% of jobs
The median wage is $43.20 / hr.
$41.94 - $45.80
24% of jobs
$48.46 is the 75th percentile. Wages above this are outliers.
$45.80 - $49.67
13% of jobs
$49.67 - $53.54
6% of jobs
$53.54 - $57.41
5% of jobs
$57.41 - $61.28
3% of jobs
$61.28 - $65.14
6% of jobs
$22
$45
$65
How much do small molecule jobs pay per hour?
What are some common challenges faced by professionals working in small molecule drug discovery roles?
Professionals in small molecule drug discovery often encounter challenges such as optimizing compound properties for both efficacy and safety, troubleshooting synthetic routes, and navigating the complexities of multi-disciplinary project teams. Balancing rapid project timelines with regulatory requirements and maintaining meticulous documentation are also crucial aspects of the role. Collaboration with biologists, pharmacologists, and analytical scientists is routine, making strong communication essential. Overcoming these challenges is rewarding and directly contributes to advancing new therapies from concept to clinical evaluation.
What is a small molecule?
A Small Molecule job typically involves research, development, manufacturing, or regulatory work related to small-molecule drugs, which are chemically synthesized compounds used in pharmaceuticals. Professionals in this field may work in drug discovery, formulation, process development, or quality control. Roles can be found in pharmaceutical companies, biotech firms, and regulatory agencies, focusing on optimizing drug efficacy, safety, and production.
What are the key skills and qualifications needed to thrive in the small molecule position, and why are they important?
To thrive in a Small Molecule position, such as a Small Molecule Scientist or Chemist, you need a strong background in organic or medicinal chemistry, analytical techniques, and drug discovery processes, often supported by a degree in chemistry, biochemistry, or a related field. Familiarity with laboratory instrumentation like HPLC, NMR, and mass spectrometry, as well as proficiency in data analysis software and adherence to GLP or GMP guidelines, is essential. Strong problem-solving skills, attention to detail, and effective teamwork and communication abilities are highly valued. These strengths enable precise experimental execution, rigorous data interpretation, and successful collaboration in developing new therapeutic compounds.

Thermo Fisher Scientific rating
7.7
Based on 423 frontline employees who took The Breakroom Quiz
198th of 538 rated manufacturers
Job description
Work Schedule
Standard (Mon-Fri)Environmental Conditions
Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)Job Description
Manager, Small Molecule
This is a fully onsite role based at our Greenfield, IN Laboratory. We welcome applicants from all locations within the US. We welcome applicants from all locations within the US. Please note that relocation assistance will be provided for this position,
Must be legally authorized to work in the United States without sponsorship.
Must be able to pass a comprehensive background check, which includes a drug screening
At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future.
Our PPD® Laboratory Services team has a direct impact on improving patient health through the expertise of scientists, industry thought leaders and therapeutic experts. As the world leader in serving science, our laboratory professionals bring their commitment to accuracy and quality to deliver groundbreaking innovations.
Discover Impactful Work:
As a Manager, you will p provide management and direction to staff and resources for project activities and needs, oversees daily operations to monitor quality and project timelines, and assists in preparation and implementation of
company policies, quality systems and training programs. Ensures responsiveness to the customer and overall, client satisfaction. Plans and monitors the progress and quality of projects by utilizing the financial and quality management tools available. Ensures that staff develop to support department goals
and business growth.
Essential Functions and Other Job Information:
Essential Functions
Oversees the daily activities of staff, including interviewing, selection,
professional development, goal setting, performance management, coaching
and mentoring.
• Reviews and approves requests for paid time off, leave, overtime, and reviews
timesheet reports for billing accuracy.
• Allocates, schedules and manages laboratory resources for group's project
activities and updates project status and revenue projections.
• Regularly communicates to staff project performance metrics, quality updates
and opportunities for staff development.
• Responsible for demonstrating process improvements and efficiency gains to
meet department goals. Defines and monitors performance metrics for quality
and productivity.
• Coordinates and prioritizes project activities with internal functional groups
(physical testing, microbiology, etc.) and support functions (QA, sample
management, etc.).
• Identifies new opportunities within client base and ability to work with
business development to pursue opportunities.
• Participates in project definition and negotiations with client on timelines and
budget.
• Participates in audits and general capabilities department tours.
• Provides recommendations to clients on analytical and compliance issues.
• Reviews and approves laboratory investigations, deviations, and QA facility
and data audits.
• Prepares and implements SOPs and company operational policies.
• Ensures adherence and makes recommendations to quality system
improvements.
• Accountable for group's knowledge and application of good practices
pertaining to GMP/GLP and / or other laboratory / client requirements.
• Participates in bi-annual SOP review & change. Ownership of changes needed
to comply with SOPs.
• Assists Sr Management in their responsibilities.
Qualifications:
Education and Experience:
• Bachelor's degree or equivalent and relevant formal academic / vocational qualification. Previous
experience that provides the knowledge, skills, and abilities to perform the job (comparable to 5-
8 years) or equivalent.
• 2+ years of management responsibility
In some cases an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
Knowledge, Skills and Abilities:
• To demonstrate behaviors which align to the 4i Values of Thermo Fisher
• Ability to train and mentor junior staff
• Ability to cultivate a collaborative work environment with a team and across business areas
• Effective written and oral communication skills as well as presentation skills
• Proven problem solving and troubleshooting abilities
• Understanding of basic financial terms and definitions as it applies to the business
• Ability to independently develop project proposals/plans
• Project and time management skills
• Proven ability to identify and implement common efficiencies across multiple programs/projects
• Demonstrated understanding of the bid process and can utilize expertise of others to develop
programs to meet unique client needs
• Proven ability to cope with a dynamic work environment
Management Role:
Manager role with responsibilities for a department, managing a team of direct reports. Demonstrates
mastery of manager skills and responsibilities through consistent, multi-year successful performance.
Focuses on effectively leading and developing team members, ensuring alignment with departmental
goals and objectives.
Benefits
We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!
Working Conditions and Environment:
Thermo Fisher Scientific values the health and wellbeing of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role:
- Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
- Able to work upright and stationary and/or standing for typical working hours.
- Able to lift and move objects up to 25 pounds.
- Able to work in non-traditional work environments.
- Able to use and learn standard office equipment and technology with proficiency.
- May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.
- Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.
- May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.
- Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.
Why Join Us?
When you join Thermo Fisher Scientific, you become part of a global team that values passion, innovation, and a commitment to scientific excellence. You’ll work in an environment where collaboration and development are part of the everyday experience—and where your contributions truly make a difference.
Apply today to help us deliver tomorrow’s breakthroughs.
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
Accessibility/Disability Access
Job Seekers with a Disability: Thermo Fisher Scientific offers accessibility service for job seekers requiring accommodations in the job application process. For example, this may include individuals requiring assistance because of hearing, vision, mobility, or cognitive impairments. If you are a job seeker with a disability, or assisting a person with a disability, and require accessibility assistance or an accommodation to apply for one of our jobs, please submit a request by telephone at 1-855-471-2255*. Please include your contact information and specific details about your required accommodation to support you during the job application process.
This telephone line is reserved solely for job seekers with disabilities requiring accessibility assistance or an accommodation in the job application process. Messages
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About Thermo Fisher Scientific
Sourced by ZipRecruiter
Industry
Biotechnology research and development
Company size
10,000+ Employees
Headquarters location
Waltham, MA, US
Year founded
1956