Single Cell Spatial Transcriptomics Jobs in Minnesota

The Research Scientist-Stem Cell Biology and Embryology will play a key role in advancing innovative approaches in cattle reproductive biology within our Innovation group. This position requires deep expertise in stem cell culture and embryology, supported by a strong foundation in developmental biology or regenerative medicine. The Scientist will lead experimental design, troubleshooting, and protocol development to drive stem cell-based advancements that directly enable next generation commercial breeding applications. 

This position reports to the Chief Scientific Officer, Recombinetics (URUS Innovation Group) and will be based in Minneapolis/St. Paul metropolitan area (onsite collaboration required). 

RESPONSIBILITIES

Stem Cell Line Development and Optimization 

• Optimize, generate, and culture stem cell lines from various sources. 

• Implement innovations to enhance quality control, consistency, and scalability of stem cell workflows. 

Experimental Design, Troubleshooting, and Method Development 

• Lead experimental design and execute studies to improve stem cell cloning applications. 

• Troubleshoot technical challenges and develop/refine protocols to improve reproducibility and outcomes. 

Differentiation and Organoid Modeling 

• Develop and optimize protocols for cattle stem cell differentiation. 

• Establish and maintain organoid models for experimental and developmental biology applications. 

Data Analysis and Interpretation 

• Analyze and interpret complex datasets, including sequencing and multiomics data. 

• Summarize findings and communicate progress to internal teams with clarity and scientific rigor. 

Cross-Functional Collaboration 

• Partner with genomics, data science, and reproductive biology teams to prioritize work streams and align project timelines. 

• Contribute to interdisciplinary planning and decision-making. 

Documentation and Quality Management 

• Maintain meticulous experimental records, lab notebooks, and data logs. 

• Develop and maintain SOPs, tracking systems, and documentation frameworks to ensure reliability and transferability of protocols. 

Continuous Learning and Innovation 

• Stay current with advances in embryology, stem cell technologies, and organoid culture. 

• Integrate emerging methods and technologies into ongoing workflows where appropriate. 

• Ph.D. in Developmental Biology, Reproductive Biology, Stem Cell Biology, or a related field, or equivalent work experience. 

• Strong scientific foundation and a track record of executing complex experiments with rigor. 

• Proven expertise in stem cells, organoid cultures and/or stem cell differentiation. 

• Experience in developmental biology or regenerative medicine is a plus. 

• Strong understanding of reproductive and molecular biology.

• Experience with bioinformatics tools, databases, and analysis methods for genomic/proteomic data. 

• Knowledge in probability, statistical modeling, and algorithm design.  

• Experience with generation or analysis of large-scale OMIC datasets (e.g., bulk transcriptomics, epigenetics and single-cell multi-omics. 

• Experience with immunofluorescence analysis, FACS sorting, microdissection, or micromanipulation is highly desirable. 

• Analytical thinking to translate biological questions into computational problems (e.g., integrating multi-omics datasets to identify genotype-phenotype links). 

• Demonstrated ability to independently design, execute, and interpret complex experiments.  

• Strong troubleshooting skills and data driven decision making.  

• Experience mentoring or leading others with high scientific rigor. 

• Excellent communication skills for interdisciplinary teamwork and reporting.  

• Team oriented mindset with willingness to support hands on lab work.  

• Adaptable, proactive, and eager to learn new tools in a fast-paced environment.