Single Cell Spatial Transcriptomics Jobs in Minnesota

Job Description
Sets up and performs routine and established lab procedures in support of lab goals, grant commitments, i.e. assays, cell/tissue culture, animal studies, etc. Monitors results, reports unusual outcomes and suggests modifications. Collects, enters and summarizes data. Assists in the maintenance of lab equipment and supplies. Performs basic statistical data analysis; prepares tables/charts/graphs and assists in organizing data. Presents at research laboratory meetings and contributes to writing of manuscripts. Works under supervision and may perform some assignments independently as discussed and approved by Principal Investigator.
Additional Information
We are seeking a highly motivated and detail-oriented Research Technologist to join our translational neuro-oncology research team. Our lab focuses on glioblastoma and peripheral nerve sheath tumors, with a strong emphasis on tumor microenvironment biology, spatial and single-cell transcriptomics, hypoxia signaling, and molecular biomarker discovery.
The successful candidate will support ongoing projects by performing established and emerging laboratory techniques, including but not limited to:
Molecular biology assays (PCR, Western blotting, RNA/DNA extraction, qPCR)
Immunohistochemistry and immunofluorescence staining on FFPE and frozen tissues
Human and murine cell culture (including primary tumor-derived lines)
Fluorescence and brightfield microscopy, image acquisition, and analysis
Mouse handling and tissue processing (training provided if needed)
Sample preparation for spatial transcriptomics, single-cell analysis, and next-generation sequencing
Data entry and assistance with manuscript and figure preparation
Organization of lab inventory, reagents, and general lab maintenance
The Research Technologist will present data in lab meetings, assist with experimental planning, and collaborate closely with senior lab members and trainees. The candidate will be expected to work independently on routine procedures and receive mentorship for more complex tasks. Opportunities for authorship on publications are available based on contributions.
Qualifications
Requires bachelor's degree in biology, chemistry, other relevant science, or an associates degree with 6 years of relevant laboratory experience. Must exhibit a solid understanding of lab techniques, equipment, and safety. Must have the ability to organize and carry out laboratory techniques independently and in a team setting. Experience with basic data analysis is required. This position requires demonstrated writing skills.
Preferred Qualifications
Bachelor's degree in biology, biomedical sciences, or a related field is required (Master's degree or relevant research experience preferred)
Minimum of 2 year of hands-on wet lab experience (academic or industry); associate degree with extensive relevant lab experience will also be considered
Proficiency in standard molecular biology techniques and mammalian cell culture
Proficiency in Western blotting, RNA/DNA extraction, qPCR, and basic data analysis (GraphPad, ImageJ, Excel/R)
Familiarity with gene silencing/knockout methods (CRISPR system, shRNA, siRNA)
Excellent organizational skills, attention to detail, and ability to work both independently and collaboratively
Strong communication and documentation skills
Experience with tissue sectioning, digital pathology, or prior exposure to spatial transcriptomics or single-cell workflows is an asset but not required. Training will be provided.
References
Three letters of recommendation will be required following an interview
About Us
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights

• Medical: Multiple plan options.
• Dental: Delta Dental or reimbursement account for flexible coverage.
• Vision: Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.

About the Team
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All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.