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Senior Systems Engineer Jobs in Roxbury Crossing, MA

QUANTERIX CORP

Senior Systems Engineer

Billerica, MA · On-site

$125K - $150K/yr

Senior Systems Engineer Billerica, MA Quanterix is a global leader in ultra-sensitive biomarker detection, enabling breakthroughs in disease research, diagnostics, and drug development. Its ...

Curtisswright

Senior Systems Engineer

Tewksbury, MA · On-site

$112K - $154K/yr

Senior Systems Engineer Our team at TCG is looking for a Senior Systems Engineer, this is a tremendous opportunity to be a part of an innovative organization that is truly making a difference in the ...

Curtiss-Wright

Senior Systems Engineer

Tewksbury, MA · On-site

$112K - $154K/yr

Senior Systems Engineer Our team at TCG is looking for a Senior Systems Engineer, this is a tremendous opportunity to be a part of an innovative organization that is truly making a difference in the ...

Addison Group

Sr. Systems Engineer

Danvers, MA · On-site

$55 - $60/hr

Beyond execution, the Senior Systems Engineer provides strategic guidance, mentors engineering staff, and drives continuous improvement across client environments. The position requires ownership of ...

Draper

Senior Systems Engineer

Cambridge, MA · On-site

$82K - $220K/yr

The Secure Solutions Group within the System's Engineering Directorate is seeking a Senior Systems Engineer to support concept and architecture, and requirement development of trustworthy secure ...

Draper

Senior Systems Engineer

Cambridge, MA · On-site

$82K - $220K/yr

The Secure Solutions Group within the System's Engineering Directorate is seeking a Senior Systems Engineer to support concept and architecture, and requirement development of trustworthy secure ...

Draper Labs

Senior Systems Engineer

Cambridge, MA · On-site

$82K - $220K/yr

The Secure Solutions Group within the System's Engineering Directorate is seeking a Senior Systems Engineer to support concept and architecture, and requirement development of trustworthy secure ...

Anduril Industries

Senior Systems Engineer

Quincy, MA · On-site

$109K - $150K/yr

ABOUT THE JOB We are seeking a highly motivated and experienced Senior Systems Engineer to join our Maritime team. You will work closely with the program leadership and a wide spectrum of cross ...

Quanterix

Senior Systems Engineer

Billerica, MA · On-site

$125K - $150K/hr

ROLE SUMMARY: The Senior Systems Engineer is a senior individual contributor responsible for providing deep technical expertise across the full lifecycle of IVD instrument development and ...

Raytheon

Senior Systems Engineer

Tewksbury, MA

$112K - $154K/yr

Raytheon is seeking a talented and motivated Senior Systems Engineer to join our team within the Systems Engineering and Test Capabilities (SETC) Discipline, supporting the LTAMDS and GhostEye Radars.

Raytheon

Senior Systems Engineer

Tewksbury, MA

$112K - $154K/yr

Raytheon is seeking a talented and motivated Senior Systems Engineer to join our team within the Systems Engineering and Test Capabilities (SETC) Discipline, supporting the LTAMDS and GhostEye Radars.

Raytheon

Senior Systems Engineer

Tewksbury, MA

$112K - $154K/yr

Raytheon is seeking a talented and motivated Senior Systems Engineer to join our team within the Systems Engineering and Test Capabilities (SETC) Discipline, supporting the LTAMDS and GhostEye Radars.

Raytheon Technologies

Senior Systems Engineer

Tewksbury, MA · On-site

$112K - $154K/yr

Raytheon is seeking a talented and motivated Senior Systems Engineer to join our team within the Systems Engineering and Test Capabilities (SETC) Discipline, supporting the LTAMDS and GhostEye Radars.

Raytheon Technologies

Senior Systems Engineer

Tewksbury, MA · On-site

$112K - $154K/yr

Raytheon is seeking a talented and motivated Senior Systems Engineer to join our team within the Systems Engineering and Test Capabilities (SETC) Discipline, supporting the LTAMDS and GhostEye Radars.

Whoop

Senior Systems Engineer

Boston, MA · On-site

$140K - $195K/yr

WHOOP is seeking a highly skilled Senior Systems Engineer to join our Systems Engineering team within the hardware organization. This position bridges multiple disciplines-Electrical, Mechanical ...

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All JobsSystems Engineer JobsSenior Systems Engineer JobsSenior Systems Engineer Jobs in Roxbury Crossing, MA

Senior Systems Engineer information

See Roxbury Crossing, MA salary details

$60.8K

$135.4K

$191.1K

How much do senior systems engineer jobs pay per year?

As of Aug 11, 2026, the average yearly pay for senior systems engineer in Roxbury Crossing, MA is $135,414.00, according to ZipRecruiter salary data. Most workers in this role earn between $113,400.00 and $155,200.00 per year, depending on experience, location, and employer.

What are some common challenges faced by senior systems engineers when integrating new technologies into existing infrastructure?

Senior Systems Engineers often encounter challenges such as ensuring compatibility between legacy systems and new technologies, minimizing downtime during migrations, and addressing unforeseen security vulnerabilities. Effective integration requires thorough planning, cross-team collaboration, and detailed testing to avoid disruptions to business operations. Staying current with emerging technologies and adopting best practices for change management are essential for overcoming these challenges and ensuring smooth implementation.

What are the key skills and qualifications needed to thrive as a senior systems engineer, and why are they important?

To thrive as a Senior Systems Engineer, you need expertise in systems architecture, troubleshooting, and network administration, typically supported by a degree in computer science or a related field and several years of relevant experience. Familiarity with virtualization platforms, cloud services (like AWS or Azure), automation tools (such as Ansible or PowerShell), and certifications like CompTIA, Microsoft, or Cisco are often required. Outstanding problem-solving, communication, and project management skills help you lead initiatives and collaborate effectively across teams. These competencies are crucial for ensuring system reliability, scalability, and security in complex IT environments.

What is a senior systems engineer?

A senior systems engineer is an IT (information technology) professional tasked with designing and maintaining network systems and security. Examples include large server or storage systems, computer networks, and mainframes. As a systems engineer, your primary duties are to oversee the daily operations of your facility and lead a team of engineers in designing new systems to replace old ones. You may work for a company that provides engineering services and solutions for other businesses, or you may be part of a large university or other institution's IT department. Skills needed for the career include the ability to work independently, leadership, and analytical problem-solving. A bachelor’s degree in electrical engineering or IT and significant experience in a lower systems engineering position are essential qualifications.

What is the difference between Senior Systems Engineer vs Systems Administrator?

AspectSenior Systems EngineerSystems Administrator
CertificationsCompTIA Security+, Cisco CCNA, Microsoft certificationsCompTIA A+, Network+, Microsoft certifications
Work EnvironmentDesigning, implementing, and troubleshooting complex systemsManaging daily system operations and user support
Industry UsageIT, technology, enterprise environmentsIT support, small to medium businesses

While both roles involve working with IT systems, Senior Systems Engineers focus on designing and implementing complex infrastructure, whereas Systems Administrators handle routine maintenance and user support. The senior role typically requires more advanced certifications and experience, and often involves strategic planning and system architecture.

More about Senior Systems Engineer jobs
What are the most commonly searched types of Systems Engineer jobs in Roxbury Crossing, MA? The most popular types of Systems Engineer jobs in Roxbury Crossing, MA are:
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What cities near Roxbury Crossing, MA are hiring for Senior Systems Engineer jobs? Cities near Roxbury Crossing, MA with the most Senior Systems Engineer job openings:
Senior Systems Engineer jobs near you

Senior Systems Engineer

QUANTERIX CORP

Billerica, MA • On-site

$125K - $150K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 7 days ago

Job description

Senior Systems Engineer
Billerica, MA
Quanterix is a global leader in ultra-sensitive biomarker detection, enabling breakthroughs in disease research, diagnostics, and drug development. Its proprietary Simoa® technology delivers industry-leading sensitivity, allowing researchers to detect and quantify biomarkers in blood and other fluids at concentrations far below traditional limits. With more than 3,400 peer-reviewed publications, Quanterix has been a trusted partner to the scientific community for nearly two decades. In 2025, Quanterix acquired Akoya Biosciences, The Spatial Biology Company®, adding multiplexed tissue imaging with single-cell resolution to its portfolio. Together, the combined company offers a uniquely integrated platform that connects biology across blood and tissue-advancing precision medicine from discovery to diagnostics.
ROLE SUMMARY:
The Senior Systems Engineer is a senior individual contributor responsible for providing deep technical expertise across the full lifecycle of IVD instrument development and commercialization. This role sits at the intersection of engineering rigor, regulatory compliance, and field excellence, supporting activities that span risk management, analytical validation, document authorship, project management.
The ideal candidate brings a strong track record of building and releasing IVD instruments under FDA/ISO design controls, firsthand immunoassay platform experience, and the technical versatility to lead both lab-bench validation work and field deployment activities. This is a highly cross-functional role requiring collaboration with R&D, Quality, Regulatory, and Commercial teams.
WHAT YOU'LL DO:
  • Lead and maintain risk management documentation (FMEA, Hazard Analysis, Risk Benefit Analysis) in accordance with ISO 14971 throughout the product lifecycle.
  • Identify, assess, and mitigate technical risks associated with instrument design, reagent-instrument interface, and clinical use scenarios.
  • Support design review processes by providing risk-informed input across mechanical, electrical, optical, and software subsystems.
  • Evaluate field failure data and complaint trends to drive corrective and preventive actions (CAPAs) back into design and risk files.
  • Author, review, and maintain design control documentation including System Requirements Specifications (SRS), Design Input/Output documents, Verification & Validation (V&V) protocols, and summary reports.
  • Maintain Design History File (DHF) completeness and traceability matrices across hardware, software, and consumable design elements.
  • Draft and revise SOPs, work instructions, test methods, service bulletins, and engineering change orders (ECOs) in compliance with QMS requirements.
  • Produce clear, technically rigorous reports suitable for regulatory submissions (510(k), PMA supplements, CE Technical Files).
  • Design and execute analytical validation studies including precision, accuracy, linearity, interferent studies, and method comparison for immunoassay-based assays and instrument platforms.
  • Apply CLSI guidelines (EP05, EP06, EP09, EP15, EP17) and relevant IVD standards to study design and data interpretation.
  • Collaborate with reagent development and assay teams to characterize reagent-instrument interactions and define release specifications.
  • Generate and defend analytical validation packages in support of regulatory submissions and customer site qualifications.

BASIC QUALIFICATIONS:
  • Bachelor's Degree in Mechanical, Electrical, or a related Engineering discipline with 10+ years experience
  • Master's Degree in Mechanical, Electrical, or a related Engineering discipline with 7+ years experience
  • Progressive experience in IVD or life sciences instrument development, with a demonstrated record of building and commercially releasing regulated diagnostic instruments.
  • Deep expertise in FDA 21 CFR Part 820 and ISO 13485 design control frameworks; direct experience authoring DHF deliverables for cleared or approved IVD products.

PREFERRED QUALIFICATIONS:
  • Hands-on Immunoassay platform experience (HD-X, SP-X, or equivalent single-molecule array technology) in a development or applications context.
  • Proven proficiency in risk management per ISO 14971, including FMEA facilitation and hazard analysis authorship.
  • Strong technical writing skills with demonstrated ability to produce regulatory-grade reports and design control documentation.
  • Experience with EMC/EMI compliance testing, test laboratories, and familiarity with IEC 61010, IEC 61326, FCC Part 15, and applicable IVD EMC standards.
  • Experience with CE marking (IVDR 2017/746) and international regulatory submissions in addition to US 510(k)/De Novo pathways.
  • Background in usability engineering per IEC 62366-1, including formative and summative studies.
  • Exposure to single-molecule detection, immunoassay development, or related ultra-sensitive biomarker measurement technologies.
  • Experience with manufacturing transfer, DFM/DFA, and production readiness reviews for complex electromechanical systems.
  • Proficiency in Python, MATLAB, or equivalent for data analysis, test automation, or instrument control.

EXPECTATIONS, COMPETENCIES, SKILLS & ABILITIES:
  • Strong cross-functional collaboration and influencing skills
  • Structured problem-solving and sound engineering judgment
  • Systems-level thinking across hardware, software, and assay interactions
  • Strong project planning, prioritization, and execution skills
  • Ability to communicate complex technical concepts clearly to diverse audiences
  • Skill in synthesizing data into clear conclusions and actionable recommendations
  • Ability to identify risks early and escalate issues appropriately
  • Ability to work independently and lead through influence in matrixed environments
  • Adaptability and sound judgment in a fast-paced, regulated environment
  • Continuous improvement mindset with strong attention to detail and quality
  • workplace location: Billerica, MA (On-site)
  • Travel 10%
  • Must lift 40 amount pounds (if applicable)
WHY YOU'LL LIKE WORKING WITH US:
Our Technology:
From discovery to diagnostics, Quanterix's ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. Simoa® technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins that are far lower than the Level of Quantification (LoQ). Our industry-leading precision instruments, digital immunoassay technology and CLIA-certified Accelerator laboratory have supported research that advances disease understanding and management in neurology, oncology, immunology, cardiology, and infectious disease.
Akoya Biosciences, a Quanterix company, is The Spatial Biology Company®-bringing tissue context to life through high-resolution, single-cell imaging. Akoya's spatial phenotyping platforms help researchers visualize and measure how cells organize and interact within tissue to influence disease progression and therapeutic response. From discovery through clinical research, Akoya offers a full continuum of solutions, including PhenoCycler®, PhenoImager® Fusion and HT, and PhenoCode™ Panels. As part of Quanterix, Akoya complements a leading portfolio of ultra-sensitive biomarker detection technologies, together enabling a more complete view of biology and disease across both tissue and blood.
Our Commitment to Employees:
At Quanterix, our values are based on: Team, Innovation, Customer and Owner.
Team: Challenge assumptions, not the person. Respect diversity of thought and hold ourselves to lofty standards
Innovation: Stay curious, experiment, create and change
Customer: Prioritize and celebrate these pioneers by doing our best to deliver on commitments
Owner: Act with high integrity and in the best interest of Quanterix. Take measured risks and learn from their success and failures.
We reward and recognize our employees by offering competitive compensation and a 401k plan with employer match, as well as competitive health, dental, and vision benefits for employees and their dependents. We also offer an unlimited vacation policy to all exempt employees, and a generous PTO policy for non-exempt employees. All employees are eligible for equity, employee stock purchase plan, a performance bonus, and 1:1 financial counseling/planning. We also offer Tuition Assistance. We have a free, state-of-the-art onsite fitness center for all employees. To keep you fueled up, we provide onsite employees free snacks and drinks every day!
DIVERSE & INCLUSIVE WORKPLACE:
Quanterix is committed to a Diverse and Inclusive workplace. We strive to recruit candidates who will bring inclusive mindsets and contribute to our values.
Quanterix is an Equal Opportunity Employer and does not discriminate based on race, national origin, gender, gender identity, sexual orientation, protected veteran status, disability, age, or other legally protected status. Quanterix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Pay Range: $125,000 - $150,000 per hour

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