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Senior Statistical Programmer Jobs in Durham, NC

Gilead

Senior Manager, Statistical Programming

Raleigh, NC · On-site

$169K - $219K/yr

We are in search of a Sr Manager, Statistical Programming to join our team! Statistical Programming- Analysis Programming: Statistical programmers work collaboratively with internal colleagues and ...

Gilead

Senior Manager, Statistical Programming

Raleigh, NC · On-site

$169K - $219K/yr

We are in search of a Sr Manager, Statistical Programming to join our team! Statistical Programming- Analysis Programming: Statistical programmers work collaboratively with internal colleagues and ...

RTI International

Senior Research Statistician

Durham, NC · On-site

$84K - $103K/yr

As a Senior Research Statistician, you will work in a collaborative, multidisciplinary environment ... Develop, validate, document, and maintain statistical programming code and analytical tools using R ...

RTI International

Senior Research Statistician

Durham, NC · On-site

$84K - $103K/yr

As a Senior Research Statistician, you will work in a collaborative, multidisciplinary environment ... Develop, validate, document, and maintain statistical programming code and analytical tools using R ...

RTI International

Senior Research Statistician

Raleigh, NC · On-site

$84K - $104K/yr

As a Senior Research Statistician, you will work in a collaborative, multidisciplinary environment ... Develop, validate, document, and maintain statistical programming code and analytical tools using R ...

RTI International

Senior Research Statistician

Raleigh, NC · On-site +1

$84K - $104K/yr

As a Senior Research Statistician, you will work in a collaborative, multidisciplinary environment ... Develop, validate, document, and maintain statistical programming code and analytical tools using R ...

RTI International

Senior Research Statistician

Raleigh, NC · On-site

$84K - $104K/yr

As a Senior Research Statistician, you will work in a collaborative, multidisciplinary environment ... Develop, validate, document, and maintain statistical programming code and analytical tools using R ...

RTI International

Senior Research Statistician

Raleigh, NC · On-site

$84K - $104K/yr

As a Senior Research Statistician, you will work in a collaborative, multidisciplinary environment ... Develop, validate, document, and maintain statistical programming code and analytical tools using R ...

PSI CRO

Senior Statistician

Durham, NC · On-site

$84K - $103K/yr

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

IQVIA

Senior Epidemiological Programmer RWE

Durham, NC

$88K - $220K/yr

This senior data analyst role sits within our Data Science, Analytics, and Technology Solutions ... Provide technical, programming, and statistical expertise and independently bring project solutions ...

Fortrea

Senior Programmer Analyst- Remote, US

Durham, NC · On-site

$90K - $120K/yr

Serve as Lead Statistical Programmer providing programming support for development and maintenance of SDTM/Client standards datasets. * Develop/validate Custom/Complex SDTM domains and efficiently ...

Ra

Marketing Analytics Manager

Raleigh, NC

Mid - Senior Level This is what you will do.. You will be using quantitative methods to assess the ... Who is proficient in Applied Statistics/Econometrics, Statistical Programming, Database Marketing ...

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Senior Statistical Programmer information

See Durham, NC salary details

$74.8K

$116.2K

$151.8K

How much do senior statistical programmer jobs pay per year?

As of Sep 1, 2026, the average yearly pay for senior statistical programmer in Durham, NC is $116,243.00, according to ZipRecruiter salary data. Most workers in this role earn between $96,900.00 and $134,100.00 per year, depending on experience, location, and employer.

What is a senior statistical programmer?

A Senior Statistical Programmer is responsible for developing, testing, and validating statistical programs used for clinical trial data analysis. They work primarily with statistical software like SAS to generate tables, listings, and figures (TLFs) for regulatory submissions and research studies. This role requires strong programming skills, knowledge of statistical methodologies, and an understanding of clinical trial processes. Senior Statistical Programmers also collaborate with statisticians, data managers, and regulatory teams to ensure data integrity and compliance with industry standards.

What are the typical responsibilities and team dynamics for a senior statistical programmer?

As a Senior Statistical Programmer, you will typically be responsible for designing, developing, and validating statistical programs for clinical trial data analysis and reporting. You’ll work closely with biostatisticians, data managers, and clinical project teams to ensure data quality and regulatory compliance, often contributing to the creation of submission datasets and study reports. The role usually involves both independent work and active collaboration, with seasoned programmers frequently mentoring junior staff and participating in process improvement initiatives. This team-oriented structure offers exposure to a variety of projects and stakeholders, making it a dynamic environment ideal for those who enjoy both analytical tasks and cross-functional teamwork.

What are the key skills and qualifications needed to thrive as a senior statistical programmer, and why are they important?

To thrive as a Senior Statistical Programmer, a strong background in statistical analysis, programming (often in SAS and R), and a relevant degree such as in statistics, mathematics, or computer science is essential. Experience with regulatory submission standards (like CDISC SDTM/ADaM), clinical trial software, and certifications such as SAS Certified Advanced Programmer are highly valued. Outstanding attention to detail, problem-solving abilities, and effective communication skills help individuals excel in this collaborative and deadline-driven role. These skills are crucial for ensuring accurate data analysis, regulatory compliance, and successful teamwork in high-stakes research environments.

What are the most commonly searched types of Statistical Programmer jobs in Durham, NC?

The most popular types of Statistical Programmer jobs in Durham, NC are:

What are popular job titles related to Senior Statistical Programmer jobs in Durham, NC?

For Senior Statistical Programmer jobs in Durham, NC, the most frequently searched job titles are:

What job categories do people searching Senior Statistical Programmer jobs in Durham, NC look for?

The top searched job categories for Senior Statistical Programmer jobs in Durham, NC are:

What cities near Durham, NC are hiring for Senior Statistical Programmer jobs?

Cities near Durham, NC with the most Senior Statistical Programmer job openings:

Senior Statistical Programmer jobs near you
Infographic showing various Senior Statistical Programmer job openings in Durham, NC as of August 2026, with employment types broken down into 1% Internship, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 78% Physical, 3% Hybrid, and 19% Remote job distribution, with an average salary of $116,243 per year, or $55.9 per hour.

Statistical Programmer / Clinical Data Architect

Volto USA

Raleigh, NC • On-site

Contractor

Re-posted yesterday

Job description

Job Description: Local to Raleigh, NC  Only!
Role Overview
We are seeking a highly experienced Senior Statistical Programmer / Clinical Data Architect with 15+ years of expertise in clinical data programming, CDISC standards, and cloud-based analytics platforms. The ideal candidate will lead end-to-end clinical data workflows, regulatory submissions, and modern data platform transformations in GxP-regulated environments.
This role requires strong domain expertise in SDTM, ADaM, regulatory submissions, and SAS/Python/R programming, combined with experience in cloud platforms (AWS/Azure) and clinical data modernization initiatives.
________________________________________
Key Responsibilities
Clinical Data Programming & Regulatory Submissions
•       Design, develop, and validate SDTM and ADaM datasets in compliance with CDISC standards
•       Lead generation of define.xml, aCRF/eCRF annotations, and submission-ready deliverables
•       Develop and optimize automated submission pipelines for FDA and global regulatory authorities
•       Ensure compliance with GxP, 21 CFR Part 11, HIPAA, and ICH E6 guidelines
Data Engineering & Automation
•       Architect and implement end-to-end clinical data pipelines using SAS, Python, and R
•       Develop reusable SAS macro libraries and automation frameworks
•       Build scalable data pipelines including modern formats (JSON/XPT alternatives)
•       Drive migration from legacy systems to modern data architectures
Cloud & Platform Engineering
•       Lead implementation and optimization of SAS Viya platforms on AWS/Azure
•       Manage cloud infrastructure components (EKS, EC2, EFS, FSx, Databricks, etc.)
•       Implement FinOps practices for cost governance and optimization
•       Evaluate and onboard next-gen analytics platforms (e.g., Databricks)
Leadership & Stakeholder Management
•       Lead cross-functional teams across US, UK, and offshore locations
•       Collaborate with clinical, statistical, regulatory, and IT stakeholders
•       Drive Agile delivery and sprint planning for data and platform initiatives
•       Manage vendor relationships, tool selection, and licensing strategies
Compliance & Governance
•       Ensure adherence to regulatory and audit requirements (FDA, OCC, SOX, Basel III as applicable)
•       Maintain audit-ready documentation and validation processes
•       Implement data governance, traceability, and reproducibility standards
________________________________________
Required Qualifications
•       Bachelor’s or Master’s degree in Computer Science, Statistics, Life Sciences, or related field
•       15+ years of experience in statistical programming and clinical data management
•       Strong expertise in:
o       SAS (Base, Macro, SQL, ODS, STAT, Graph)
o       CDISC standards (SDTM, ADaM, define.xml)
o       Regulatory submissions (FDA, global agencies)
•       Hands-on experience with:
o       Python (Pandas) and/or R (admiral, Shiny)
o       Cloud platforms (AWS/Azure)
•       Strong understanding of GxP and clinical compliance frameworks
________________________________________
Preferred Qualifications
•       Experience with SAS Viya architecture and administration
•       Familiarity with Databricks, DBT, or modern data engineering tools
•       Knowledge of CI/CD tools (Jenkins, Git)
•       Experience in financial/regulatory environments (Basel III, CCAR, OCC) is a plus
•       AWS or cloud certifications
________________________________________
Key Skills
•       Clinical Data Standards: SDTM, ADaM, CDISC
•       Programming: SAS, Python, R, SQL
•       Cloud: AWS, Azure
•       Tools: Pinnacle 21, Git, Jenkins, Power BI, Grafana
•       Methodologies: Agile, DevOps, Data Governance