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Senior Scientist Downstream Process Development Jobs in Worcester, MA

AT Process Technologies

Process Chemist

Waltham, MA · On-site

$130K - $200K/yr

Summary We are seeking a process development chemist to own and execute the research, development ... Develop and optimize core synthesis and downstream processing, evaluating competing technical ...

Qnity Electronics, Inc.

Senior Scientist

Marlborough, MA · On-site

$94K - $129K/yr

Position Summary Qnity Electronics is seeking an innovative Senior Scientist to join our ... development of next-generation spin-on photolithography materials and processes that enable ...

Qnity

Senior Scientist

Marlborough, MA · On-site

$94K - $129K/yr

Position Summary Qnity Electronics is seeking an innovative Senior Scientist to join our ... development of next-generation spin-on photolithography materials and processes that enable ...

BPGbio, Inc.

Senior Scientist, Waltham, MA

Waltham, MA · On-site

$120 - $150/hr

... process. Senior Scientist Full Time Waltham, MA, US 5 days ago Requisition ID: 1233 Salary Range ... development. ESSENTIAL DUTIES AND RESPONSIBILITIES: * Design and execute discovery and targeted ...

New

AbbVie

Senior Scientist, II

Worcester, MA · On-site

$91K - $124K/yr

Conceive and execute novel scientific research or development that achieves projects and area goals ... Develop and validate mechanistic and hybrid models for CHO based cell culture and downstream ...

AbbVie

Senior Scientist, II

Worcester, MA · On-site

$109K/yr

Conceive and execute novel scientific research or development that achieves projects and area goals ... Develop and validate mechanistic and hybrid models for CHO based cell culture and downstream ...

AbbVie

Senior Scientist, II

Worcester, MA · On-site

$91K - $124K/yr

Conceive and execute novel scientific research or development that achieves projects and area goals ... Develop and validate mechanistic and hybrid models for CHO based cell culture and downstream ...

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All JobsScientist Downstream Process Development JobsSenior Scientist Downstream Process Development JobsSenior Scientist Downstream Process Development Jobs in Worcester, MA

Senior Scientist Downstream Process Development information

See Worcester, MA salary details

$66.4K

$110.3K

$164.1K

How much do senior scientist downstream process development jobs pay per year?

As of Aug 19, 2026, the average yearly pay for senior scientist downstream process development in Worcester, MA is $110,304.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,300.00 and $124,700.00 per year, depending on experience, location, and employer.

What does a senior scientist in downstream process development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.

What are the key skills and qualifications needed to thrive as a senior scientist in downstream process development?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What are some common challenges faced by senior scientists in downstream process development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.

What are popular job titles related to Senior Scientist Downstream Process Development jobs in Worcester, MA?

For Senior Scientist Downstream Process Development jobs in Worcester, MA, the most frequently searched job titles are:

What job categories do people searching Senior Scientist Downstream Process Development jobs in Worcester, MA look for?

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Cities near Worcester, MA with the most Senior Scientist Downstream Process Development job openings:

Senior Scientist Downstream Process Development jobs near you
Infographic showing various Senior Scientist Downstream Process Development job openings in Worcester, MA as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $110,304 per year, or $53 per hour.

Biprocess Engineer

Integrated Resources INC

Devens, MA

Contractor

Re-posted 9 days ago

Job description

Job Description

Process Engineer Scientific:

  • MS&T organization is seeking to fill a Process Engineer position for an 8+ month contract.
  • The successful candidate will provide meaningful contributions toward commercial manufacturing support, process monitoring, technology transfer and process validation activities.
  • The successful candidate will have a demonstrated background in bioprocessing (upstream and/or downstream), experience troubleshooting manufacturing processes and strong technical documentation skills (memos, protocols, reports).

Responsibilities

  • Work independently to provide commercial manufacturing technical support, process monitoring, technology transfer and process validation activities for downstream processes.
  • Provide process troubleshooting during scale-up and routine manufacturing. Provide process subject matter expertise and ownership of assigned deliverables.
  • The successful candidate will work effectively in highly cross-functional project teams, matrix management environments, as well as independent working environments to support the site.
  • Perform data analysis and monitoring for process performance and product quality outputs.
  • The position will interface with Manufacturing, Quality, Engineering, and internal MS&T departments at multiple sites throughout the BMS network
  • Strong communication and technical writing skills are required.

Qualifications:

  • B.S./M.S. or Ph.D. in Chemical Engineer, Biochemical Engineer, Biomedical Engineer, Biochemistry or related field (Advanced degree is preferred)
  • Required: Prior experience (Ph.D.: 0 - 2 years; BS/MS: 2 - 6 years) in process development, process validation or manufacturing support in bioprocessing (upstream and/ or downstream)
  • Preferred: Prior experience scaling up biopharma manufacturing processes (upstream/downstream), facility fit assessments, process scale-up from bench/ pilot to production, process troubleshooting and optimization, and process validation
  • Hands-on experience working with chromatography, ultrafiltration and depth filtration process acquired through lab, pilot or production scale experience.
  • Preferred: Experience performing manufacturing investigations for biologics manufacturing.
  • Preferred: Experience providing start-up support for new biologics manufacturing processes (Person-In-Plant)
  • Preferred: Experience with statistical methodologies (DOE, SPC, etc.), cGMP regulations, and regulatory requirements is expected.

Keywords: Manufacturing Technical Support (MTS), Manufacturing Sciences & Technology (MS&T/MSAT), process validation, PPQ, technology transfer, facility fit, scale-up, process development, bioprocessing

Qualifications
  • Prior experience (Ph. D.: 0 - 2 years; BS/MS: 2 - 6 years) in process development, process validation or manufacturing support in bio-processing (upstream and/ or downstream)
Additional Information

All your information will be kept confidential according to EEO guidelines.

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About Integrated Resources

Sourced by ZipRecruiter

Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.

Industry

Recruiting and staffing services

Company size

51 - 200 Employees

Headquarters location

Edison, NJ, US

Year founded

1996

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