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Senior Scientist Downstream Process Development Jobs in Worcester, MA

AbbVie

Senior Scientist I

Worcester, MA · On-site

$91K - $124K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Contribute to project science in area of expertise. Develop productive collaborations and ... process development, including chromatography, TFF, and associated downstream unit operations.

AbbVie

Senior Scientist I

Worcester, MA · On-site

$91K - $124K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

... process development, including chromatography, TFF, and associated downstream unit operations ... Routinely demonstrate scientific initiative and creativity in research or development activities.

AbbVie

Senior Scientist I

Worcester, MA · On-site

$96K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Contribute to project science in area of expertise. Develop productive collaborations and ... process development, including chromatography, TFF, and associated downstream unit operations.

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Senior Scientist Downstream Process Development information

See Worcester, MA salary details

$66.4K

$110.3K

$164.1K

How much do senior scientist downstream process development jobs pay per year?

As of Aug 19, 2026, the average yearly pay for senior scientist downstream process development in Worcester, MA is $110,304.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,300.00 and $124,700.00 per year, depending on experience, location, and employer.

What does a senior scientist in downstream process development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.

What are the key skills and qualifications needed to thrive as a senior scientist in downstream process development?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What are some common challenges faced by senior scientists in downstream process development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.

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For Senior Scientist Downstream Process Development jobs in Worcester, MA, the most frequently searched job titles are:

What job categories do people searching Senior Scientist Downstream Process Development jobs in Worcester, MA look for?

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Senior Scientist Downstream Process Development jobs near you
Infographic showing various Senior Scientist Downstream Process Development job openings in Worcester, MA as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $110,304 per year, or $53 per hour.

Senior Scientist I, Quality Control

Candel Therapeutics

Needham, MA • On-site

$155K - $160K/yr

Full-time

Re-posted 29 days ago

Job description

Salary $155K - $160K
On site role in Needham
Senior Scientist I, Quality Control is responsible for executing highly complex analytical assays supporting clinical and commercial programs. This position collaborates with external manufacturing and tech transfer and is focused on Adenovirus and Herpesvirus vectors, associated cell-based potency assays, as well as performing training of new technical staff and troubleshooting and validation of new and established assays. The Senior Scientist I, Quality Control works with various cell lines, performs analytical methods, trends quality attributes, and suitability of product lines for continued use.
Essential Areas of Responsibility:
  • Participate in the development of cell culture and viral vector production using Adenovirus and Herpesvirus production systems.
  • Function as subject matter expert (SME) for technical platforms and new methodologies.
  • Perform assays in support of process development including cell-based assays, ELISA, HPLC, qPCR, SDS-PAGE, UV-spectroscopy.
  • Generate, manage, evaluate, and maintain critical data in a highly organized manner and document in paper or Electronic Laboratory notebook.
  • Participate in the development, optimization, and validation of new assays.
  • Assist with the development of SOPs and batch records for use in Quality Control, or external CMOs.
  • Interact with other departments such as Analytical development, Quality Assurance, Regulatory Affairs, Research, Upstream and Downstream Process Development.
  • Contribute to laboratory support duties associated with operating a QC laboratory.
  • Guide, direct, and train direct reports and team members, including performance monitoring, constructive feedback, quality standards, etc.
  • Able to react to change productively and handle other essential tasks as assigned.

Minimum Education, Experience and Skill Requirements:
Education:
  • PhD or equivalent in biology, chemistry, biochemistry, or related field plus applicable experience. (Internship and/or post-doctoral experience is also accepted)

Experience:
  • Hands-on experience with aseptic techniques related to mammalian cell culture (Vero and HEK293 cells lines)
  • Hands-on experience in laboratory techniques supporting virus, protein and DNA analysis: SDS-PAGE, Western Blot, BCA, residual DNA, HPLC, ELISA.
  • Willingness to learn (new methods, drug development processes, new modalities, etc.) and ability to demonstrate scientific curiosity and innovation.
  • Previous experience in small biotech/pharma company.
  • Previous experience working with viruses.
  • Ability to work independently.
  • Familiarity with basic regulatory expectations around product control strategies and the ICH guidelines for method qualification.
  • Familiarity with Drug Substance and Drug Product release and stability testing programs.
  • A strong background in one or more analytical techniques such as various HPLC based methods, microplate UV/Vis/Luminescent assays, cell-based assays including virus quantification and potency, qPCR, electrophoresis, sizing techniques such as DLS, etc.
  • Ability to write technical documents, including but not limited to method SOPs, development reports, qualification reports, method transfer protocols and method transfer report.
  • Functional understanding of GxP principles.
  • Strong computer skills and good verbal and written communication skills.
  • Very good collaboration and team building skills.

Must be authorized to work in the US. No sponsorships available.
We are not accepting resumes from agencies at this time.

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