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Senior Python Startup Jobs in New York (NOW HIRING)

David Joseph & Company

Senior AI Engineer

Manhattan, NY · On-site

$170 - $220/hr

... stage startup building the AI operating system for the CFO office -- audit-ready AI agents that ... Python (primary stack) Requirements * 2+ years building and shipping production AI agents * 4+ ...

StackAI

Senior DevOps Engineer

New York, NY · On-site

$130K - $210K/yr

Comfort with scripting/programming (Python, Bash, or similar). * Experience with monitoring ... Previous startup experience. Why Stack AI? * Work at the cutting edge of AI + infrastructure

Beam Impact

Senior Data Engineer

New York, NY · On-site +1

$176K - $198K/yr

Testing automation via pytest * uv as our Python package manager * Snowflake as our data warehouse ... Experience in an early startup * Experience with setting up and administrating a Business ...

Beli

Senior Software Engineer

Manhattan, NY · On-site

$134K - $177K/yr

As a Senior Software Engineer, you will lead the research, design, implementation, and support of ... a startup or high-growth environment • Highly skilled in Javascript/Typescript and Python • ...

Shiftsmart

Senior Software Engineer

Manhattan, NY · On-site

$100 - $130/hr

Python, Javascript/Typescript, Node.js, React Native and more. * Software expert: 4+ years of ... Startup hungry: eager to work in a dynamic, fast-paced early-stage startup, with ability to roll up ...

NxT Level

Senior Backend Engineer

Manhattan, NY · On-site

Design and maintain high performance APIs using Python and cloud services to handle millions of ... Founder level ownership mindset or early stage startup experience preferred * Ability to work ...

NxT Level

Senior Backend Engineer

Manhattan, NY

Design and maintain high performance APIs using Python and cloud services to handle millions of ... Founder level ownership mindset or early stage startup experience preferred * Ability to work ...

EliseAI

Senior Software Engineer

Manhattan, NY · On-site

$134K - $177K/yr

Required : • Startup mindset with a strong sense of ownership, urgency, and pragmatism in ... Python • Willingness to work in person at our office 4-5 days a week Preferred : • ...

Clarasight

Senior Software Engineer

New York, NY · On-site

$134K - $176K/yr

We are seeking a Senior Software Engineer to join our founding team. As one of our first ... Bring full-stack experience (e.g., React/TypeScript, Node.js, Python, or similar). * Have startup ...

De Circle

Clerq - Senior Software Engineer

New York, NY · On-site

$134K - $176K/yr

We are looking for a Senior Software Engineer to join our early engineering team. The ideal ... with Python/Django strongly preferred) * Previous (early stage) startup experience is a plus

Revin AI

Senior Software Engineer

New York, NY · On-site

$200K - $275K/yr

You'll work end-to-end across a Python/FastAPI backend, a Next.js/TypeScript dashboard, and the ... a startup, high-velocity SaaS, or AI-driven company - Production LLM experience - you've shipped ...

EliseAI

Senior DevOps Engineer

Manhattan, NY · On-site

$143K - $183K/yr

... startup • Strong AWS experience, including services like EC2, ECS, RDS, Lambda, and IAM • ... Python) and infrastructure-as-code tools (e.g., Terraform) • Strong software engineering ...

ProNexus

Senior Software Engineer

Manhattan, NY · On-site +1

$134K - $177K/yr

... in Python, React, and PostgreSQL - Experience in a VC-backed startup or growth-stage environment preferred - Healthcare, mental health, or benefits platform experience is a plus - Strong product ...

ProNexus

Senior Software Engineer

Manhattan, NY · Remote

$125K - $165K/yr

... in Python, React, and PostgreSQL - Experience in a VC-backed startup or growth-stage environment preferred - Healthcare, mental health, or benefits platform experience is a plus - Strong product ...

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All JobsPython Startup JobsSenior Python Startup JobsSenior Python Startup Jobs in New York

Senior Python Startup information

What is the difference between Senior Python Startup vs Python Developer?

AspectSenior Python StartupPython Developer
CredentialsBachelor's or higher in CS, experience in startupsBachelor's in CS or related field, some experience
Work EnvironmentFast-paced startup, cross-functional teamsEstablished companies or startups, team-based
Industry UsageTech startups, innovative projectsVaried industries, software development
Search IntentSenior roles, startup environment, advanced skillsEntry to mid-level roles, Python programming

Senior Python Startup roles typically require more experience, leadership skills, and familiarity with startup environments. Python Developers may have similar technical skills but often at an earlier career stage and in more established settings. The main difference lies in experience level and work context, with Senior Python Startup positions emphasizing leadership and startup agility.

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Senior Python Startup jobs near you
Infographic showing various Senior Python Startup job openings in New York as of August 2026, with employment types broken down into 2% Internship, 84% Full Time, 7% Part Time, 1% Temporary, and 6% Contract. Highlights an 80% Physical, 6% Hybrid, and 14% Remote job distribution.

Senior Software Engineer (AI Health-Tech SaaS)

Phamily

New York, NY • On-site

$140K - $175K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 3 days ago

Job description

Sr. Software Engineer
Whether your background is in general full-stack development or you're more interested in HL7/FHIR interoperability and healthcare integrations, we have opportunities aligned with both paths. We'd love to find the role that best matches your interests and experience.
Location: Open to Hybrid or Fully Remote Candidates
Job Type: Full-time
Job Reports To: Tech Lead
Salary Range: $140,000-$175,000 plus full benefits
About Jaan Health/Phamily
Jaan Health is a leading AI-based care management company serving healthcare providers. For nearly a decade, the company has leveraged its easy-to-use, proprietary technology to enable health systems, medical groups, and ACOs to deliver high-quality, high-ROI proactive care to hundreds of thousands of previously underserved patients.
Phamily, the company's core technology platform, has transformed chronic disease management with clinically tested AI and easy-to-use technology that enables physicians and care teams to offer high-touch, individualized patient care that has been proven to reduce investment in extra labor and the overall cost of care. Phamily helps ensure healthcare providers are compensated fairly for providing high-quality care between office visits, while improving the lives of patients with chronic diseases. Learn more at phamily.com.
Job/Role Description:
We are seeking entrepreneurial Senior Software Engineers to join our high-impact, fast-moving engineering team. You will help design, build, and scale core components of our AI-driven care management platform. This role is ideal for engineers who thrive in startup environments, enjoy rapid iteration cycles, and are motivated by building products that directly improve patient outcomes and healthcare delivery systems. You'll work across the full stack, contributing to architecture decisions, product development, and continuous improvement of a complex SaaS platform used in real-world clinical settings.
Key Responsibilities:
  • Architect and build full-stack feature end-to-end (Ruby on Rails, Python, SQL, JS/Vue/React)
  • Drive technical vision, code quality standards, and engineering best practices
  • Communicate complex concepts simply and help technical and non-technical teams align
  • Ship quickly in iterative cycles: prototype, launch, iterate, scale
  • Make pragmatic trade-offs to deliver value fast while maintaining product integrity
  • Use AI tools to speed up engineering output for yourself and your team
  • Build, maintain, and scale SaaS products that serve real patients and clinicians
  • Own migrations, services, APIs, and long-term maintainability
  • Design and implement high-quality, maintainable, and well-tested code
  • Contribute to system architecture and technical design decisions
  • Improve performance, scalability, and reliability of core platform systems
  • Work across backend, frontend, and infrastructure layers as needed
  • Continuously refactor and improve existing codebases
Requirements:
  • 7+ years of full lifecycle software engineering experience
  • You've built, shipped, and maintained production SaaS systems for years
  • Strong architectural instincts and ability to coach others
  • Clear communicator with high signal and low ego
  • Startup or fast-paced environment experience
  • Clean high-quality production code
  • Good UX / product design sense
  • JavaScript, HTML, CSS
  • Vue.js / React / SPA (Single Page Apps)
  • Ruby on Rails / Python / Elixir
  • SQL / PostgreSQL / MySQL
  • TDD / RSpec / Playwright
  • AWS, GCP, Docker, Kubernetes
  • AI implementation
  • Healthcare, SaaS, or startup experience

Preferred requirements:
  • Bonus: Healthcare, HL7/FHIR, data ingestion, ML/LLM interest
  • Entrepreneurial DNA: A 'builder' mentality with the ability to operate effectively in high-ambiguity environments where processes may not be fully fleshed out.

Work style & logistics (drive home location and travel reqs here):
We are a fast-growing, early-stage company with a bold mission and significant work ahead; every employee at Jaan Health must embody growth company DNA. This means you have proven success in a high-performing environment: high velocity, strong ownership, comfort with ambiguity, resilience, and a true growth mindset.
You are both a playbook builder and executor, able to design scalable approaches for today while anticipating what the business will need tomorrow, and then follow through to deliver results.
Our culture is built on five principles that shape how we work, lead, and grow:
  • Care: We put patients, clients, teammates, and outcomes first.
  • Curiosity: We ask better questions, challenge assumptions, and keep learning.
  • Clarity: We simplify complexity, communicate directly, and create alignment.
  • Co-Creation: We collaborate across teams, perspectives, and disciplines.
  • Craftsmanship: We execute with excellence, ownership, and continuous improvement.

Our Compensation & Benefits
  • Competitive compensation based on experience and impact
  • Comprehensive medical, dental, and vision coverage for employees and dependents at a low cost
  • Generous Paid Time Off: up to 35 paid days off each year so you can recharge, recover, and give back, including:
    • 12 vacation days accrued annually for rest, travel, and personal time
    • Up to 9 sick/wellness days to prioritize your health and well-being
    • 12 paid company holidays throughout the year
    • 2 paid give-back days
  • HSA and FSA account options
  • 401(k) with company match after 6 months of full-time employment
    • 100% match on the first 3% contributed, and 50% match on the next 2% contributed
  • A collaborative, mission-driven team helping transform healthcare at scale

If you take pride in delivering results, embrace challenges, and proactively seek improvement, then this is the place for you. You'll join a smart, humble, and collaborative team dedicated to improving healthcare.
Equal Employment Opportunity
This position is not eligible for visa sponsorship.
Phamily is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, genetics, veteran status, sexual orientation, gender identity or expression, or any other legally protected status.

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