ZipRecruiter

Log In

1

Senior Python Software Engineer Jobs in Jacksonville, FL

ApplyMint

Senior Software Engineer

Jacksonville, FL · On-site

$108 - $132/hr

Senior Software Engineer Jacksonville, FL Starting Salary $120,000+ DOE Position Summary Tactical ... Strong proficiency in two or more programming languages (e.g., Java, C++, Python, or JavaScript)

SS&C

Senior Software Engineer

Jacksonville, FL · Hybrid

$113K - $149K/yr

Senior Software Engineer Locations: Evansville, IN / New York / Boston, MA / Waltham, MA ... Develop and maintain scripts using Linux Shell, Windows Command, SQL, VB Script, Python, PowerShell ...

New

Availity

Software Engineer IV

Jacksonville, FL · On-site

$120 - $170/hr

The Software Engineer IV will provide senior technical leadership for the design, development, and ... Scala* Python (including NumPy, Pandas, and related data libraries)* SQL databases* Scripting ...

Yusen Logistics

Senior Software Engineer

Jacksonville, FL · On-site

$113K - $149K/yr

The Senior Software Engineer is an experienced full stack developer with a proven track record of developing both front and back-end systems. The Sr. Software Engineer designs and builds full stack ...

Tihinsurance

Software Engineer

Ponte Vedra Beach, FL

... in a senior or consulting role. * Required technical skills include C#.NET, SQL Server, T-SQL ... Proficiencyin programming languages such as Java, C#, Python, or similar. Strong knowledge of cloud ...

Smart AutoCare

Senior Software Engineer

Jacksonville, FL · On-site

$113K - $149K/yr

Job Title: Sr Software Engineer Department: IT Pay Grade: Overtime Eligibility: Exempt Date: June, 2026 Job Summary : We are seeking an innovative, high-caliber Senior Software Engineer to drive the ...

Kavaliro

Senior Backend Software Engineer

Jacksonville, FL · On-site

$111K - $146K/yr

Kavaliro is seeking a Senior Backend Software Engineer for our local Jacksonville client. In this ... Experience with real-time systems using technologies such as C++, MFC, Python, SQL, VBA, PHP ...

CRC Group

Software Engineer

Ponte Vedra Beach, FL · On-site

... in a senior or consulting role. * Required technical skills include C#.NET, SQL Server, T-SQL ... C#, Python, or similar. • Strong knowledge of cloud platforms (AWS, Azure, or GCP) and ...

Relativity

Software Engineer

Jacksonville, FL · On-site

Experience building backend services using languages such as C#, Python, or similar * Understanding of software engineering disciplines and the ability to work across multiple layers of the ...

PNC Bank

Software Engineer Sr

Jacksonville, FL

$113K - $149K/yr

As a Software Engineer Sr within PNC's Technology organization, you will be based in Farmers Branch, TX. Technical Experience Core Engineering Advanced Java expertise o Core Java o Spring Boot ...

next page

Showing results 1-20

All JobsPython Software Engineer JobsSenior Python Software Engineer JobsSenior Python Software Engineer Jobs in Jacksonville, FL

Senior Python Software Engineer information

See Jacksonville, FL salary details

$51K

$131.6K

$180.7K

How much do senior python software engineer jobs pay per year?

As of Aug 25, 2026, the average yearly pay for senior python software engineer in Jacksonville, FL is $131,550.00, according to ZipRecruiter salary data. Most workers in this role earn between $112,600.00 and $151,500.00 per year, depending on experience, location, and employer.

What does a senior Python software engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.

What are the key skills and qualifications needed to thrive as a senior Python software engineer?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What are some common challenges faced by senior Python software engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

Which senior Python software engineer job is in demand?

Senior Python software engineering roles are in high demand across industries such as technology, finance, and healthcare, especially for positions involving data analysis, machine learning, and web development. Skills in frameworks like Django or Flask, along with experience in cloud platforms and version control, enhance job prospects in this field.

What are popular job titles related to Senior Python Software Engineer jobs in Jacksonville, FL?

For Senior Python Software Engineer jobs in Jacksonville, FL, the most frequently searched job titles are:

What job categories do people searching Senior Python Software Engineer jobs in Jacksonville, FL look for?

The top searched job categories for Senior Python Software Engineer jobs in Jacksonville, FL are:

What cities near Jacksonville, FL are hiring for Senior Python Software Engineer jobs?

Cities near Jacksonville, FL with the most Senior Python Software Engineer job openings:

Senior Python Software Engineer jobs near you
Infographic showing various Senior Python Software Engineer job openings in Jacksonville, FL as of June 2026, with employment types broken down into 78% Full Time, 11% Part Time, 3% Temporary, and 8% Contract. Highlights an 84% Physical, 4% Hybrid, and 12% Remote job distribution, with an average salary of $131,550 per year, or $63.2 per hour.

Senior Python- AI/Agentic Developer

Software Guidance & Assistance

Jacksonville, FL • On-site

$112K - $151K/yr

Other

Posted 21 days ago

Job description

Software Guidance & Assistance, Inc., (SGA), is searching for a Senior Python AI - AI/Agentic Systems for a contract assignment with one of our premier Healthcare Services clients in Jacksonville, FL. (Occasional onsite visits required to office)
This is a W-2 opportunity due to client requirements.
The client is unable to provide sponsorship, facilitate visa transfers, or engage third-party C2C candidates.
The final interview will be conducted in person in Jacksonville, FL.
This role has the potential to convert to a full-time employee (FTE) position.
Responsibilities :
Seeking a Senior AI Developer with specialized expertise in Python-based agentic AI systems to join our enterprise development team. This role focuses on designing, developing, and maintaining sophisticated AI agent architectures that support our organization's digital transformation initiatives while maintaining compliance with enterprise security and governance standards.
  • Architecture & Development
    • Design and implement production-grade AI agent systems using LangGraph and AgentCore frameworks
    • Develop and maintain agentic AI solutions that integrate with enterprise systems while adhering to security standards and configuration baselines
    • Build and optimize MCP (Model Context Protocol) servers and clients for seamless agent-to-system communication
    • Architect scalable Python-based applications supporting complex AI workflows and multi-agent orchestration
  • Security & Compliance
    • Ensure all developed systems comply with organizational security standards, including Database Technology Security Standard (1500) and Secure Coding and Application Design Security Standard (2509)
    • Implement secure coding practices aligned with CIS and DISA STIG guidelines
    • Collaborate with Information Security to integrate technical controls and security baselines into agent systems
    • Maintain audit trails and nonrepudiation requirements for all data transformation operations performed by AI agents
    • Ensure systems do not leverage unapproved databases or persist restricted/confidential data on end-user devices
  • Integration & Operations
    • Integrate AI agents with enterprise databases and applications following vendor recommendations and tested configurations
    • Work with Architecture Review Board processes for technology evaluation and implementation approval
    • Support deployment of agents in SOC2 and HITRUST-compliant environments
    • Maintain systems at vendor-approved release versions to protect against known security vulnerabilities
  • Collaboration & Knowledge Management
    • Partner with Information Security and Database Administration teams on security implementation and incident response
    • Participate in security exception request processes when necessary
    • Contribute to organizational security awareness and best practices documentation
    • Stay current with AI/ML security trends, threat intelligence, and emerging vulnerabilities
Required Skills:
  • Related Bachelor's degree in an IT related field or relevant work experience
  • 5-8 years of related work experience or equivalent combination of transferable experience demonstrating proficiency and experience in design, implementation, monitoring and troubleshooting technology
  • 5+ years professional Python development experience
  • 3+ years hands-on experience with LangGraph framework and agentic AI system design
  • 2+ years demonstrated expertise building and deploying AI Agents in production environments
  • 2+ years experience developing and managing MCP servers and clients
  • 2+ years working with AgentCore or equivalent enterprise AI orchestration frameworks
  • Strong understanding of multi-agent system architecture and agent communication patterns
  • Proficiency in secure coding practices and application security design
  • Experience with enterprise database technologies and data governance
  • Security & Compliance Knowledge
    • Demonstrated understanding of healthcare/enterprise security standards and compliance frameworks
    • Experience implementing audit logging and nonrepudiation controls
    • Familiarity with SOC2, HITRUST, or equivalent compliance requirements
    • Knowledge of CIS and DISA STIG guidelines as applied to application development
  • Professional Competencies
    • Advanced problem-solving and system design capabilities
    • Strong communication skills for cross-functional collaboration with security and infrastructure teams
    • Ability to balance innovation with security and compliance requirements
    • Experience working in regulated environments (healthcare, financial services, or equivalent)
Preferred Skills:
  • Experience with vector databases and retrieval-augmented generation (RAG) systems
  • Familiarity with enterprise API gateway and service mesh technologies
  • Background in healthcare IT or HIPAA-regulated environments
  • Contributions to open-source AI/ML projects
  • Certifications in security (CISSP, CCSK) or cloud platforms (AWS, Azure)
SGA is a technology and resource solutions provider driven to stand out. We are a women-owned business. Our mission: to solve big IT problems with a more personal, boutique approach. Each year, we match consultants like you to more than 1,000 engagements. When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work. Please find us at .
#LI-TP1
SGA is an Equal Opportunity Employer and does not discriminate on the basis of Race, Color, Sex, Sexual Orientation, Gender Identity, Religion, National Origin, Disability, Veteran Status, Age, Marital Status, Pregnancy, Genetic Information, or Other Legally Protected Status. We are committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, and our services, programs, and activities. Please visit our company to request an accommodation or assistance regarding our policy.

Apply