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Senior Python Software Engineer Jobs in Fort Mill, SC

1 point system

Sr Python Developer

Fort Mill, SC · Remote

$124K - $167K/yr

Job Title Sr Python Developer Location 100% Remote Work Duration 6 months + (Contract) MUST HAVE ... AI Tools - Claude, Codex, etc Role Overview We are seeking a Senior Software Engineer to support a ...

Sarian, Inc.

Sr. Python Web Developer

Charlotte, NC · On-site

$118K - $159K/yr

Role: Sr. Python Web Developer/Only USC & GC Location: Charlotte, NC Onsite position Fulltime position *****NO C2C***** JD Skill: Sr. Python Web Developer * 9 - 14 Years of experience as Sr.Python ...

Sarian, Inc.

Sr. Python Web Developer

Charlotte, NC · On-site

$118K - $159K/yr

Role: Sr. Python Web Developer Location: Charlotte, NC Onsite position Fulltime position JD Skill: Sr. Python Web Developer * 9 - 14 Years of experience as Sr.Python Web Developer * Expert in Python ...

Value Technology Inc

Senior Python Developer

Charlotte, NC · On-site

$118K - $159K/yr

Senior Python Developer Location: Charlotte, NC (Onsite) Experience: 10+ years Job Summary Value Technology Inc. is hiring for Senior Python Developer where Candidate will be responsible for analysis ...

Accord Technologies Inc.

Python developer

Charlotte, NC · On-site

$49 - $67.75/hr

Sr Python developer Work Location : Charlotte NC Face to Face interview needed in charlotte NC 12 ... in software development. * Strong proficiency in Python with frameworks like Flask, FastAPI, or ...

Everblue

Senior Software Engineer

Huntersville, NC · On-site

$115K - $151K/yr

The Senior Software Engineer collaborates closely with product management, UX/UI design, quality ... Proficiency with Python and JavaScript, including frameworks such as React or Next.js. * Experience ...

Everblue

Senior Software Engineer

Huntersville, NC · On-site

$115K - $151K/yr

The Senior Software Engineer collaborates closely with product management, UX/UI design, quality ... Proficiency with Python and JavaScript, including frameworks such as React or Next.js. * Experience ...

Wells Fargo

Senior Specialty Software Engineer

Charlotte, NC · On-site

$119K - $157K/yr

We are seeking a Senior Specialty Software Engineer to spearhead the integration of Generative AI ... You will lead a team in developing state-of-the-art Python-based AI applications that leverage LLMs ...

New

Judge Group, Inc.

Software Engineer

Charlotte, NC · On-site

$68 - $73/hr

Senior Software Engineer - Agentic AI & Intelligent Automation We are not accepting C2C or 1099 ... Strong experience with Python development. * Experience building and consuming REST APIs.

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All JobsPython Software Engineer JobsSenior Python Software Engineer JobsSenior Python Software Engineer Jobs in Fort Mill, SC

Senior Python Software Engineer information

See Fort Mill, SC salary details

$48.3K

$124.8K

$171.4K

How much do senior python software engineer jobs pay per year?

As of Aug 6, 2026, the average yearly pay for senior python software engineer in Fort Mill, SC is $124,761.00, according to ZipRecruiter salary data. Most workers in this role earn between $106,800.00 and $143,700.00 per year, depending on experience, location, and employer.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

What are some common challenges faced by senior Python software engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What are the key skills and qualifications needed to thrive as a senior Python software engineer?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What does a senior Python software engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.
What job categories do people searching Senior Python Software Engineer jobs in Fort Mill, SC look for? The top searched job categories for Senior Python Software Engineer jobs in Fort Mill, SC are:
Senior Python Software Engineer jobs near you
Infographic showing various Senior Python Software Engineer job openings in Fort Mill, SC as of August 2026, with employment types broken down into 88% Full Time, 8% Part Time, and 4% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $124,761 per year, or $60 per hour.

Sr Python Developer

1 point system

Fort Mill, SC • Remote

$124K - $167K/yr

Contractor

Posted 14 days ago

Job description

Hi ,
I hope you're doing well.

I'm reaching out regarding an exciting opportunity that I believe aligns well with your background and skill set.

To move forward, could you please provide the following details along with latest copy of resume:

two references are required in order to submit for this role. Without those I won’t be able to submit you.

Work Authorization and Expiry (If any)

LinkedIn Profile URL

Current Location with Zip code

Pay Expectation on W2 (hourly)

Complete JD:

Job Title

Sr Python Developer

Location

100% Remote Work

Duration

6 months + (Contract)

MUST HAVE:

  • 7+ years of experience, senior level
  • Experience in Design and Development
  • Full Stack with Python, Django, and Typescript
  • Typescript
  • Heavy APIs on backend
  • MySQL

Nice-to-Have / Preferred:

  • AI Tools – Claude, Codex, etc

Job Description:

Role Overview

We are seeking a Senior Software Engineer to support a core monolithic system that orchestrates lab order intake, processing, and interpretation. This role requires an individual who can take ambiguous, complex problems and drive them to completion. The successful candidate will act as a technical leader, mentoring other engineers and raising the bar for the team in architecture and execution, with a heavy focus on integration work connecting internal systems with lab pipelines.

Key Responsibilities

  • Own and deliver projects across product, platform, and stakeholder teams.
  • Design, develop, and maintain a central, monolithic system built on Python and Django.
  • Develop and enhance system integrations and core platform functionality with a strong emphasis on API-driven architecture.
  • Perform foundational engineering work focused on system improvements, stability, and modernization.
  • Provide production support, including participating in an on-call rotation and troubleshooting bugs.
  • Mentor teammates and elevate the team's technical execution standards.
  • Communicate clearly with both technical and non-technical audiences.

Required Qualifications

Experience: A minimum of 7+ years of professional software engineering experience is required. Candidates must demonstrate strong experience in system design, development, and real-world application architecture.

Technical Skills: Proficiency in Python and Django is mandatory. Candidates must have full-stack experience with a strong backend emphasis, including heavy API development and experience with TypeScript and MySQL.

Education: A formal degree is not required. Experience and technical skill are prioritized.

Preferred Qualifications

  • Experience in healthcare technology, clinical laboratory, or genomics industries.
  • Knowledge of AWS-native environments and cloud platforms.
  • Familiarity with containerization, Kubernetes, or infrastructure-as-code tools like Terraform.
  • Experience designing and maintaining API platforms that serve multiple internal consumers.
  • Familiarity with AI development tools such as Claude or Codex.

Thank You

Ranjeet Kumar | 1Point System LLC

Senior Technical Recruiter
• Email: ranjeet@1pointsys.com • Fax: 803-832-7973 • www.1pointsys.com

https://www.linkedin.com/in/ranjeet-kumar-829a4525b/

If you are unable to reach me directly, please feel free to contact my supervisor at ashish.trivedi@1pointsys.com . They will be able to assist you with any inquiries or provide the support you need.


115 Stone Village Drive • Suite C • Fort Mill, SC • 29708

         An E-Verified company | An Equal Opportunity Employer