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Senior Python Software Engineer Jobs in Cincinnati, OH

MidWest Startup creating applications that allow consumers to take control of their data

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Senior Python Developer, Unique Niche Expanding Startup, Startup Exper

Cincinnati, OH · On-site

$125K - $145K/yr

Senior Python Software Engineer, Python Applications, Unique Start Up, U.S. Company. Perm-Direct Hire role, Expanding Team, Unique Consumer Data Based Application. Our Mission : We're a fast-moving ...

KPI Solutions

Senior Software Engineer

Cincinnati, OH · Hybrid

$117.50K - $155K/yr

Senior Software Engineer (Contract-to-Perm) with KPI Solutions in Cincinnati, OH 6-month contract to permanent | Hybrid / Position is based in Cincinnati, OH Do you want to build software that ...

TQL

Senior Software Engineer

Cincinnati, OH · On-site +1

$117.50K - $154.90K/yr

As a Senior Software Engineer, you will be joining one of our agile teams responsible for developing web-based versions of our core applications as well as identifying opportunities to trial and ...

Cincinnati Children's

Senior Software Engineer

Cincinnati, OH · On-site

$117.60K - $155.10K/yr

Join to apply for the Senior Software Engineer role at Cincinnati Children's We have launched a new business venture at Cincinnati Children's. As part of this effort, we have established a new ...

Huntington

Sr. Innovation Software Engineer

Cincinnati, OH · On-site +1

$117.50K - $155K/yr

The Senior Innovation Software Engineer will partner closely across the Innovation team to develop ... Java, Python, TypeScript/JavaScript, or similar) and/or experience leveraging AI-assisted ...

Total Quality Logistics

Senior Software Engineer

Cincinnati, OH · On-site

$117.50K - $154.90K/yr

As a Senior Software Engineer, you will be joining one of our agile teams responsible for developing web-based versions of our core applications as well as identifying opportunities to trial and ...

DataAnnotation

Software Engineer

Cincinnati, OH · Remote

$40/hr

We are looking for a Software Engineer to join our team to train AI models. You will measure the ... To apply to this role, you will need to be proficient in either Python and/or JavaScript. Your role ...

DataAnnotation

Software Engineer

Wyoming, OH · Remote

$40/hr

We are looking for a Software Engineer to join our team to train AI models. You will measure the ... To apply to this role, you will need to be proficient in either Python and/or JavaScript. Your role ...

SynergisticIT

Software Engineer (Remote)

Cincinnati, OH · On-site

Currently, we are looking for entry-level software programmers, IT enthusiasts, Python/Java developers, data analysts/data scientists. We welcome candidates with all visas and citizens to apply. Who ...

SynergisticIT

Junior Software Engineer

Cincinnati, OH · On-site

Currently, we are looking for entry-level software programmers, Java full stack developers, Python/Java developers, data analysts/data scientists, machine learning engineers for full time positions ...

Belcan

Embedded Software Engineer

Cincinnati, OH · On-site

$119.79K/yr

Embedded Software Engineer Embedded Software Engineer positions offered by Belcan Services Group ... Python scripting language; and CAN/SAE J1939 and Ethernet. Position reports to Belcan HQ in ...

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Senior Python Software Engineer information

See Cincinnati, OH salary details

$52.8K

$136.2K

$187.1K

How much do senior python software engineer jobs pay per year?

As of May 28, 2026, the average yearly pay for senior python software engineer in Cincinnati, OH is $136,222.00, according to ZipRecruiter salary data. Most workers in this role earn between $116,600.00 and $156,900.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Python Software Engineer, and why are they important?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What are some common challenges faced by Senior Python Software Engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What does a Senior Python Software Engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

What are popular job titles related to Senior Python Software Engineer jobs in Cincinnati, OH? For Senior Python Software Engineer jobs in Cincinnati, OH, the most frequently searched job titles are:
What job categories do people searching Senior Python Software Engineer jobs in Cincinnati, OH look for? The top searched job categories for Senior Python Software Engineer jobs in Cincinnati, OH are:
What cities near Cincinnati, OH are hiring for Senior Python Software Engineer jobs? Cities near Cincinnati, OH with the most Senior Python Software Engineer job openings:
Senior Python Software Engineer jobs near you
Infographic showing various Senior Python Software Engineer job openings in Cincinnati, OH as of May 2026, with employment types broken down into 78% Full Time, 19% Part Time, 1% Temporary, and 2% Contract. Highlights an 86% Physical, 3% Hybrid, and 11% Remote job distribution, with an average salary of $136,222 per year, or $65.5 per hour.

Senior Python Developer, Unique Niche Expanding Startup, Startup Exper

MidWest Startup creating applications that allow consumers to take control of their data

Cincinnati, OH • On-site

$125K - $145K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 5 days ago

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Job description

Senior Python Software Engineer, Python Applications, Unique Start Up, U.S. Company.

Perm-Direct Hire role, Expanding Team, Unique Consumer Data Based Application.

Our Mission: We’re a fast-moving startup unlocking secure, meaningful access to sensitive consumer data—think health, finance, and beyond. Our platform turns fragmented data into actionable insights, with privacy at its core.

What You’ll Build:

  • Scalable backend services in Python (FastAPI) and/or Node.js
  • Secure data ingestion pipelines (FHIR, Plaid, or similar)
  • High-performance PostgreSQL and/or MongoDB integrations
  • Full Stack Applications Development...front end coding development: JavaScript, React, Angular, HTML, Vue, SPA or similar.
  • Clean, test-driven code with full coverage
  • CI/CD pipelines for rapid, reliable deployment
  • Privacy-first architecture for sensitive consumer data, experience with PyCrypto, PyCA and/or the Python Security Toolkit are pluses

Desired Skills/Experience:

  • Experience working in a similar Full-Stack Python Developer role for a smaller company or a startup company.
  • Recent/Current Experience with Python-based Consumer/Customer/Non-Business Facing Web Based Applications Development.
  • 5+ years backend Python focused software engineering/applications development experience
  • Strong with FastAPI, Node.js, and data ingestion APIs
  • Experience creating and coding the front end of Python based applications: JavaScript/TypeScript, HTMX, Angular, React, etc.
  • Deep database connectivity expertise (experience with ETL development is a plus)
  • Experience working in a Test-driven development environment (where you have tested your own code)
  • CI/CD pipeline creation experience
  • Experience creating software and applications with heavy data security and data privacy component (ideally for consumer data) is a strong plus.

Apply now and help shape the future of secure data innovation.

Competitive Salary, Benefits and Equity-Stock Options...Apply Today!

Company Description

Extremely Successful Founder and CEO (has had several Very Successful 'exits'); Expanding Fast Paced startup, great benefits, salary and equity, Exciting New Application changing the way consumers can get access and control of their data allowing for more informative decision making, leverage and increasing their chances for financial success, health and wellness and overall equity in a changing environment, Python and Data Security Driven environment.