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Senior Python Full Stack Developer Jobs in Santa Fe, TX

Addison Group

Full Stack Engineer

Houston, TX · On-site

$75 - $95/hr

Experience with CI/CD pipelines and modern DevOps practices. What We're Looking For * A true full ... Senior Software Engineer * Product Engineer * Solutions Engineer * Engineers from consulting ...

Kanak Elite Services Inc

Sr. Python Developer

Houston, TX · On-site

$116K - $156K/yr

Role: SR. PYTHON DEVELOPER Location: Houston, TX (Onsite) local Only Local Houston Strong Python Application Development exp We are currently seeking an experienced Python Developer to join the Big ...

Team Velocity

Senior Full Stack .NET Developer

Houston, TX · On-site

$150K - $175K/yr

Senior Full Stack .NET Developer Remote | $150,000 $175,000 Annually We are seeking a highly skilled Senior Full Stack .NET Developer to join our growing engineering team. This role is ideal for a ...

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Senior Python Full Stack Developer information

See Santa Fe, TX salary details

$53.8K

$117.3K

$165.8K

How much do senior python full stack developer jobs pay per year?

As of Sep 14, 2026, the average yearly pay for senior python full stack developer in Santa Fe, TX is $117,296.00, according to ZipRecruiter salary data. Most workers in this role earn between $98,500.00 and $136,500.00 per year, depending on experience, location, and employer.

What is a senior Python full stack developer?

Senior Python Full Stack Developers are experienced software engineers who specialize in both frontend and backend web development using Python and related technologies. They are responsible for designing, building, and maintaining complex web applications, often leading teams and making architectural decisions. Their expertise typically includes frameworks like Django or Flask for backend development, as well as JavaScript frameworks such as React or Angular for the frontend. In addition to coding, they often mentor junior developers and ensure best practices in software development. Their role requires a deep understanding of databases, APIs, deployment processes, and modern development workflows.

What are the key skills and qualifications needed to thrive as a senior Python full stack developer?

To thrive as a Senior Python Full Stack Developer, you need advanced proficiency in Python, JavaScript frameworks (such as React or Angular), database management, and a solid understanding of both front-end and back-end development principles, often backed by a degree in computer science or related experience. Familiarity with tools like Django or Flask, RESTful APIs, version control systems (e.g., Git), and cloud platforms is typically required. Excellent problem-solving abilities, effective communication, and the ability to mentor junior developers are standout soft skills for this role. These skills ensure robust, scalable applications and foster effective collaboration across technical teams, driving project success.

What are some common challenges faced by senior Python full stack developers when working on cross-functional teams?

Senior Python Full Stack Developers often collaborate with designers, product managers, and DevOps specialists, which can present challenges in aligning technical solutions with business goals and user experience expectations. Balancing backend performance with frontend responsiveness and maintaining clear communication across disciplines are key hurdles. Additionally, staying updated with rapidly evolving frameworks and ensuring code quality and scalability across the stack requires continual learning and adaptability. Successful developers proactively bridge these gaps by fostering open dialogue and advocating for best practices throughout the development process.

What is the difference between Senior Python Full Stack Developer vs Backend Developer?

AspectSenior Python Full Stack DeveloperBackend Developer
Required SkillsProficiency in Python, JavaScript, HTML/CSS, frameworks like Django/Flask, React or AngularStrong Python skills, experience with server-side development, databases, APIs
Work EnvironmentFull-stack development across front-end and back-end, often in agile teamsPrimarily server-side, database, and API development
Industry UsageTech companies, startups, enterprises needing full-stack solutionsWeb services, SaaS, enterprise applications

The main difference is that a Senior Python Full Stack Developer handles both front-end and back-end development, requiring skills in multiple technologies, while a Backend Developer focuses mainly on server-side logic, databases, and APIs. The full-stack role demands broader expertise, whereas backend roles are more specialized in server-side development.

What cities near Santa Fe, TX are hiring for Senior Python Full Stack Developer jobs?

Cities near Santa Fe, TX with the most Senior Python Full Stack Developer job openings:

Senior Python Full Stack Developer jobs near you

Senior Full Stack Developer (Agentic AI)

Houston, TX • On-site

myDNA, Inc.
See more jobs at myDNA, Inc.external

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 17 days ago

Job description

Our Purpose
Our mission is to build a healthier and more connected world with precision health and genealogy services.
We empower individuals with actionable insights into their genetic makeup, fostering a deeper understanding of their ancestry, health, and wellness. By integrating the experience of Gene by Gene Laboratory Services, FamilyTreeDNA genealogy, and myDNA reporting services, we strive to deliver cutting-edge genetic testing and personalized solutions that inspire informed decisions and enhance quality of life. Our team is dedicated to advancing the field of genomics through innovation, research, and a commitment to excellence.
Our Values
All employees are expected to demonstrate our values of Innovate, One Team, and Integrity when carrying out the accountabilities and responsibilities of their role. This how we show up every day for ourselves, our colleagues and our customers and strategic partners to deliver our vision and strategic goals.
Position Overview
We are seeking a Senior Full Stack Developer (Agentic AI) to join our engineering team. In this hands-on senior role, you will be responsible for building, maintaining, and scaling production-grade full-stack applications that integrate agentic AI capabilities. You will leverage modern AI-assisted development tools to dramatically accelerate delivery and elevate code quality, while maintaining deep hands-on oversight to ensure our solutions remain reliable, maintainable, and implementable. Your focus will be on the practical implementation, stability, and state management of AI agents within our existing product ecosystem, ensuring they operate reliably in a regulated environment. This includes implementing robust guardrails, security protocols, and testing/auditing mechanisms to ensure safe and predictable AI agent behavior. As a senior individual contributor, you will own features from local development through to automated CI/CD deployment and infrastructure management.
Accountabilities and Responsibilities
  • Design, build, and maintain scalable, robust full-stack features using C#, .NET, and modern frontend frameworks (Angular or React).
  • Integrate agentic AI workflows into production, building reliable state management and execution patterns to ensure agent consistency across complex, multi-step tasks.
  • Write and tune complex SQL queries and design database schemas across MS SQL Server and PostgreSQL to support traditional and AI-driven features.
  • Manage and scale AWS cloud infrastructure using Infrastructure-as-Code (Terraform or CloudFormation), while maintaining automated CI/CD pipelines for rapid, compliant production deployments.
  • Implement comprehensive observability and monitoring for traditional application logic and agentic AI components to ensure system uptime, performance, and reliability.
  • Participate in peer code reviews, mentor junior team members, establish shared engineering standards, and drive continuous improvement in an iterative Agile/Scrum environment.

Position Requirements
Experience, Skills & Knowledge
  • 8+ years of professional software engineering experience with deep expertise in C#, .NET Core, and modern frontend frameworks (Angular/React).
  • Proven experience integrating AI models and agentic workflows into production applications, with a strong focus on building stable, predictable systems in regulated environments.
  • Production experience with AWS cloud infrastructure (Lambda, RDS, Bedrock) managed via Infrastructure-as-Code (Terraform/CloudFormation).
  • Strong testing discipline: unit, integration, and contract testing, plus the ability to build evaluation harnesses for AI features.
  • Excellent written and verbal communication; ability to explain technical and AI-related tradeoffs to non-technical, legal, and compliance stakeholders.
  • Mentorship & Collaboration: A desire to mentor junior team members and foster a collaborative engineering culture through effective peer code reviews.
  • Agile Proficiency: Comfortable working in an iterative, Agile/Scrum environment with a focus on delivering incremental value.
  • Learning Agility: A proactive learner who stays current with the rapidly evolving AI landscape and contributes to team knowledge sharing.
  • Problem-Solving: Exceptional analytical skills, with a track record of diagnosing and resolving complex, production-level performance and stability issues.

Compliance, Governance & Technologies
  • Demonstrated success in implementing safety guardrails, security protocols, and auditability for AI-driven features.
  • Proficiency in leveraging AI-assisted development tools (e.g., Claude Code, GitHub Copilot, Cursor) to accelerate delivery, improve code quality, and maintain high standards of reliability and maintainability.
  • Demonstrable experience delivering software within highly regulated, audit-ready environments (e.g., HIPAA, CAP/CLIA, or similar compliance frameworks).
  • Experience with AI orchestration patterns (e.g., RAG pipelines, agentic state management) and frameworks (e.g., LangChain, Semantic Kernel).
  • Experience implementing custom observability and evaluation patterns, such as leveraging OpenTelemetry for distributed tracing, monitoring model latency/hallucinations, and building automated validation harnesses.

Education
  • Bachelor's degree in Computer Science or related field.

Why Join Us
At Gene by Gene, you'll join a mission-driven team advancing the science of genetics and discovery. You'll have the opportunity to shape meaningful campaigns, tell compelling brand stories, and collaborate with talented professionals who share your passion for creativity, curiosity, and impact.
Comprehensive Benefits
  • Medical & Health Savings: Choice of 3 medical tiers generously sponsored by the company, with a monthly $50-$100 employer HSA contribution based on plan type and dependent level.
  • 100% Covered Dental & Vision: No premium costs for employees or dependents.
  • 401(k) Matching: Generous 50% company match up to 6% of annual base salary.
  • Diverse PTO Framework: Structured time off incorporating vacation, sick leave, mental health days, personal days, company holidays, and a flexible floating holiday.
  • Income Protection & Family Leave: Full company sponsorship of Short-Term and Long-Term Disability (STD/LTD) alongside Paid Family Leave offerings.

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