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Senior Python Full Stack Developer Jobs in Knoxville, TN

ITR

Full Stack Developer

Oak Ridge, TN

Full Stack Developer Project: American Science Cloud / Genesis Project Experience Level: Mid-Level ... Python * MCP (Model Context Protocol or similar frameworks) * Experience working with Agentic AI ...

ITR

Full Stack Developer

Knoxville, TN

Position Overview Seeking a versatile Full Stack Software Engineer to support multiple concurrent ... Python * SQL * Backend Frameworks-Fast API * Frontend FrameworksVue.js 2 & Vue.js 3 * State ...

Xcel Engineering

Full Stack Developer

Oak Ridge, TN · On-site

JOB OVERVIEW XCEL Engineering is seeking a versatile Full Stack Software Engineer to support ... JavaScript, TypeScript, Python, SQL * Backend Frameworks-Fast API * Frontend FrameworksVue.js 2 & ...

Xcel Engineering

Full Stack Developer

Oak Ridge, TN · On-site

JOB OVERVIEW XCEL Engineering is seeking a versatile Full Stack Software Engineer to support ... JavaScript, TypeScript, Python, SQL * Backend Frameworks-Fast API * Frontend FrameworksVue.js 2 & ...

Xcel Engineering

Full Stack Developer

Oak Ridge, TN

JOB OVERVIEW XCEL Engineering is seeking a versatile Full Stack Software Engineer to support ... JavaScript, TypeScript, Python, SQL * Backend Frameworks-Fast API * Frontend FrameworksVue.js 2 & ...

CGI Inc.

AWS Python Developer

Knoxville, TN · On-site

$48 - $66/hr

AWS Python Developer Category: Software Development/ Engineering Main location: United States ... CGI is seeking an AWS Senior Full Stack Cloud Engineer to design, develop, and support modern cloud ...

Cadre5

Full Stack AI Engineer

Knoxville, TN

Full Stack AI Engineer Founded in 1999 in the beautiful Smoky Mountains of East Tennessee, Cadre5 ... Python * MCP (Model Context Protocol or similar frameworks) * Experience working with Agentic AI ...

CGI

AWS Python Developer

Knoxville, TN · On-site

CGI is seeking an AWS Senior Full Stack Cloud Engineer to design, develop, and support modern cloud ... Strong Python development experience for backend services and enterprise applications . Hands on ...

CGI Inc.

AI/ML Engineer

Knoxville, TN · On-site

CGI is actively seeking a Senior AI/ML and Emerging Tech Expert to join our Emerging Technologies ... This role blends full stack engineering with modern AI/ML, integrating generative AI and advanced ...

Smith & Wesson Brands, Inc.

AI Developer

Maryville, TN · On-site

Proficiency in Python and other applicable programming languages. Understanding of governance ... Power Platform / Copilot Studio Azure AI services, OpenAI-compatible APIs, or comparable stacks RPA ...

Pilot Company

Sr Engineer, AI

Knoxville, TN · On-site

$86K - $118K/yr

Pilot's Senior AI Engineer will drive technical decisions, own complex projects, demonstrate deep ... Collaborates with product, research, and platform teams Full Stack Development * Architect end-to ...

Pilot Flying J

Sr Engineer, AI

Knoxville, TN · On-site

$86K - $118K/yr

Pilot's Senior AI Engineer will drive technical decisions, own complex projects, demonstrate deep ... Collaborates with product, research, and platform teams Full Stack Development * Architect end-to ...

Pilot Company

Sr Engineer, AI

Knoxville, TN

$86K - $118K/yr

Pilot's Senior AI Engineer will drive technical decisions, own complex projects, demonstrate deep ... Collaborates with product, research, and platform teams Full Stack Development * Architect end-to ...

Pilot Company

Sr Engineer, AI

Knoxville, TN · On-site

$86K - $118K/yr

Pilot's Senior AI Engineer will drive technical decisions, own complex projects, demonstrate deep ... Collaborates with product, research, and platform teams Full Stack Development * Architect end-to ...

ITR

Cloud Software Engineer

Oak Ridge, TN

$57.25 - $74.50/hr

Full-Stack Development: Write clean, maintainable, and efficient code in Python (for backend logic ... High proficiency in Python and JavaScript (Node.js/React preferred). * DevOps Toolchain:

Cadre5

Software Engineer- Vue

Knoxville, TN

Design, architect, and develop full-stack applications from concept to completion. * Work on ... Python * SQL * Backend Frameworks-Fast API * Frontend Frameworks Vue.js 2 amp; Vue.js 3 * State ...

Varsity Tutors

Web Development Tutor

Knoxville, TN · Remote

$18 - $40/hr

Ability to explain client-server architecture, MVC patterns, and authentication while preparing students for full-stack development roles and software engineering careers. * Conceptual Teaching ...

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Senior Python Full Stack Developer information

See Knoxville, TN salary details

$56.8K

$123.9K

$175.1K

How much do senior python full stack developer jobs pay per year?

As of Jul 30, 2026, the average yearly pay for senior python full stack developer in Knoxville, TN is $123,880.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,000.00 and $144,100.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Python Full Stack Developer, and why are they important?

To thrive as a Senior Python Full Stack Developer, you need advanced proficiency in Python, JavaScript frameworks (such as React or Angular), database management, and a solid understanding of both front-end and back-end development principles, often backed by a degree in computer science or related experience. Familiarity with tools like Django or Flask, RESTful APIs, version control systems (e.g., Git), and cloud platforms is typically required. Excellent problem-solving abilities, effective communication, and the ability to mentor junior developers are standout soft skills for this role. These skills ensure robust, scalable applications and foster effective collaboration across technical teams, driving project success.

What is the difference between Senior Python Full Stack Developer vs Backend Developer?

AspectSenior Python Full Stack DeveloperBackend Developer
Required SkillsProficiency in Python, JavaScript, HTML/CSS, frameworks like Django/Flask, React or AngularStrong Python skills, experience with server-side development, databases, APIs
Work EnvironmentFull-stack development across front-end and back-end, often in agile teamsPrimarily server-side, database, and API development
Industry UsageTech companies, startups, enterprises needing full-stack solutionsWeb services, SaaS, enterprise applications

The main difference is that a Senior Python Full Stack Developer handles both front-end and back-end development, requiring skills in multiple technologies, while a Backend Developer focuses mainly on server-side logic, databases, and APIs. The full-stack role demands broader expertise, whereas backend roles are more specialized in server-side development.

What are Senior Python Full Stack Developers?

Senior Python Full Stack Developers are experienced software engineers who specialize in both frontend and backend web development using Python and related technologies. They are responsible for designing, building, and maintaining complex web applications, often leading teams and making architectural decisions. Their expertise typically includes frameworks like Django or Flask for backend development, as well as JavaScript frameworks such as React or Angular for the frontend. In addition to coding, they often mentor junior developers and ensure best practices in software development. Their role requires a deep understanding of databases, APIs, deployment processes, and modern development workflows.

What are some common challenges faced by Senior Python Full Stack Developers when working on cross-functional teams?

Senior Python Full Stack Developers often collaborate with designers, product managers, and DevOps specialists, which can present challenges in aligning technical solutions with business goals and user experience expectations. Balancing backend performance with frontend responsiveness and maintaining clear communication across disciplines are key hurdles. Additionally, staying updated with rapidly evolving frameworks and ensuring code quality and scalability across the stack requires continual learning and adaptability. Successful developers proactively bridge these gaps by fostering open dialogue and advocating for best practices throughout the development process.
What job categories do people searching Senior Python Full Stack Developer jobs in Knoxville, TN look for? The top searched job categories for Senior Python Full Stack Developer jobs in Knoxville, TN are:
What cities near Knoxville, TN are hiring for Senior Python Full Stack Developer jobs? Cities near Knoxville, TN with the most Senior Python Full Stack Developer job openings:
Senior Python Full Stack Developer jobs near you

Full Stack Developer

ITR

Oak Ridge, TN

Full-time

Re-posted 15 days ago

Job description

  • This position is onsite at a Department of Energy facility in Oak Ridge, Tennessee.
  • Must be eligible for a federal security clearance (US Citizen)

Job Title: Full Stack Developer
Project: American Science Cloud / Genesis Project
Experience Level: Mid-Level (5+ Years)

Position Overview
We are seeking a highly motivated and adaptable Full Stack Developer to support the American Science Cloud / Genesis Project. This role is ideal for a driven professional who thrives in fast-paced environments and brings a “can-do” attitude to solving complex technical challenges. You will play a key role in designing and developing modern, intelligent user interfaces powered by emerging Agentic AI systems.

Key Responsibilities
  • Design, develop, and maintain responsive, high-performance front-end applications
  • Collaborate with cross-functional teams to integrate AI-driven features into user interfaces
  • Work within fast-paced, iterative development cycles to deliver production-ready solutions
  • Implement and optimize workflows leveraging Agentic AI frameworks
  • Contribute to architecture decisions and front-end best practices
  • Integrate APIs and backend services using modern development standards
  • Participate in code reviews, testing, and continuous improvement processes
  • Support deployment and scaling of applications within the American Science Cloud ecosystem
Required Qualifications
  • Bachelor’s Degree in Computer Science, Software Engineering, or related field
  • 5+ years of professional experience in front-end or full-stack development
  • Strong proficiency in:
    • JavaScript
    • Python
    • MCP (Model Context Protocol or similar frameworks)
  • Experience working with Agentic AI systems or AI-driven development environments
  • Hands-on experience with tools such as Claude Code and OpenClaw
  • Proven ability to work effectively in fast-paced, dynamic project environments
  • Strong problem-solving skills and a proactive, “can-do” mindset
  • U.S. Citizenship required
Preferred Qualifications
  • Master’s Degree in Computer Science, Engineering, or related discipline
  • Experience working on large-scale cloud-based platforms or government-related projects
  • Familiarity with modern front-end frameworks (React, Vue, etc.)
  • Experience integrating AI/ML models into production applications
  • Strong understanding of UI/UX principles and performance optimization
Key Attributes
  • Self-starter with strong ownership mentality
  • Comfortable navigating ambiguity and evolving project requirements
  • Team-oriented with excellent communication skills
  • Passion for innovation, especially in AI-driven technologies
Why Join This Project?
This is an opportunity to contribute to a cutting-edge initiative at the intersection of cloud computing and Agentic AI. You will help shape next-generation systems within the American Science Cloud / Genesis Project, working alongside forward-thinking engineers and innovators.