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Senior Python Flask Jobs in Saint Louis, MO (NOW HIRING)

Leidos

Software Engineer SME

Wood River, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

South Roxana, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

National Stock Yards, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Glen Carbon, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Saint Charles, MO · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Hazelwood, MO · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Granite City, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Maryville, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Arnold, MO · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Roxana, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Chesterfield, MO · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Saint Louis, MO · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Ballwin, MO · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Dupo, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Columbia, IL · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

New

Leidos

Software Engineer SME

Bridgeton, MO · On-site

$131K - $237K/yr

The SME will serve as a senior technical authority within the development team, helping establish ... Python, Java, and JavaScript * Advanced Programming: Go * Front-end and Back-end Frameworks: React ...

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All JobsPython Flask JobsSenior Python Flask JobsSenior Python Flask Jobs in Saint Louis, MO

Senior Python Flask information

See Saint Louis, MO salary details

$53.5K

$138K

$189.6K

How much do senior python flask jobs pay per year?

As of Sep 12, 2026, the average yearly pay for senior python flask in Saint Louis, MO is $138,032.00, according to ZipRecruiter salary data. Most workers in this role earn between $118,100.00 and $159,000.00 per year, depending on experience, location, and employer.

What is a senior Python Flask developer?

A Senior Python Flask Developer is an experienced software engineer who specializes in building web applications using the Flask framework and the Python programming language. They are responsible for designing, developing, testing, and maintaining backend services and APIs, often working with databases, cloud services, and other technologies. Senior developers are also expected to mentor junior team members, lead projects, and ensure code quality and best practices throughout the development process.

What are the key skills and qualifications needed to thrive as a senior Python Flask developer?

To thrive as a Senior Python Flask Developer, you need advanced proficiency in Python programming, experience with the Flask framework, and a solid understanding of RESTful APIs, typically supported by a degree in computer science or related field. Familiarity with tools like Git, Docker, SQL/NoSQL databases, and cloud platforms such as AWS or Azure is commonly required, along with relevant certifications. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastering these skills ensures you can build robust, scalable web applications and lead project success in dynamic development environments.

What are some common challenges senior Python Flask developers face when working on large-scale web applications?

Senior Python Flask developers often encounter challenges such as managing application scalability, ensuring code maintainability, and integrating with various third-party services. Handling complex database relationships and optimizing API performance are also common issues, especially as user traffic grows. Effective collaboration with frontend developers and DevOps teams is essential to address deployment, security, and continuous integration concerns, making strong communication and problem-solving skills crucial for success in this role.

What is the difference between Senior Python Flask vs Python Developer?

AspectSenior Python FlaskPython Developer
Primary FocusWeb application development using Flask framework, with leadership responsibilitiesGeneral Python programming, including scripting, data analysis, and application development
Experience LevelAdvanced, with expertise in Flask, architecture, and mentoringEntry to mid-level, with broad Python skills
CertificationsOften includes Python or web development certificationsMay have Python certifications, but less specialized
Work EnvironmentTech companies, startups, or agencies focusing on web appsVaried industries, including data science, automation, and software development

Senior Python Flask roles focus on building and leading web applications with Flask, requiring specialized knowledge and leadership. Python Developers have broader Python skills applicable across multiple domains. The choice depends on whether you want to specialize in web development or pursue general Python programming.

Is senior Python Flask in demand?

Senior Python Flask developers are in high demand due to the framework's popularity for building scalable web applications and APIs. Companies seek professionals with experience in Python, Flask, and related tools like SQL databases and cloud platforms, reflecting strong job growth in software development roles.

Which senior Python Flask job has the highest salary?

Senior Python Flask developers with specialized skills in cloud computing, microservices, or data engineering tend to have the highest salaries. Roles in industries like finance, technology, and healthcare often offer higher compensation, especially for those with extensive experience and certifications in relevant frameworks and tools.
Senior Python Flask jobs near you
Infographic showing various Senior Python Flask job openings in Saint Louis, MO as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $138,032 per year, or $66.4 per hour.

Senior Software Engineer with Security Clearance

Saint Louis, MO • On-site

Gateway Geospatial Group
See more jobs at Gateway Geospatial Groupexternal

$119K - $157K/yr

Other

Re-posted 27 days ago

Key responsibilities

  • Design, develop, test, deploy, and sustain mission-critical software applications.

  • Build modern web applications, APIs, and microservices architectures supporting geospatial and intelligence missions.

  • Participate in all phases of the software development lifecycle, including collaboration with stakeholders and supporting modernization efforts.

Job description

About the role Gateway Geospatial Group (G3) is seeking Software Engineers to support a mission-critical development program within the National Geospatial-Intelligence Agency (NGA). Working alongside government and industry engineers, you will help develop and modernize geospatial, intelligence, data, and cloud-enabled capabilities that directly support national security missions. As part of NGA's DevCorps engineering ecosystem, you will contribute to the design, development, deployment, and sustainment of enterprise applications while tackling complex challenges in cloud computing, DevSecOps, automation, geospatial technologies, and large-scale data processing. This is an opportunity to work with modern technologies and deliver solutions that make a real-world impact. Responsibilities * Design, develop, test, deploy, and sustain mission-critical software applications * Build modern web applications, APIs, and microservices architectures * Develop cloud-native solutions supporting enterprise-scale geospatial and intelligence missions * Collaborate with Product Owners, Government Technical Leads, and Agile development teams to deliver user-focused capabilities * Participate in all phases of the software development lifecycle, from requirements analysis through deployment and sustainment * Contribute to DevSecOps pipelines and Continuous Integration / Continuous Delivery (CI/CD) processes * Implement automated testing, test-driven development, and software quality assurance practices * Integrate software with enterprise services, data repositories, APIs, and cloud platforms * Support modernization efforts involving legacy systems, emerging technologies, and cloud migration initiatives * Participate in Agile ceremonies including sprint planning, backlog refinement, retrospectives, and demonstrations * Develop technical documentation, system requirements, and user-facing materials as required Required qualifications * Active TS/SCI clearance * U.S. Citizenship * Experience developing software using Java, Python, JavaScript, or comparable modern programming languages * Experience with full software development lifecycle activities * Experience developing RESTful APIs and service-based architectures * Experience with relational databases and data modeling * Experience working in Agile software development environments * Experience with automated testing, CI/CD pipelines, or DevSecOps practices * Strong problem-solving, communication, and collaboration skills * Tech Stack Includes: * Languages * Java * Python * JavaScript / TypeScript * Front-End Frameworks * Angular * React * Vue.js * Back-End Frameworks * Spring Boot * Flask * Express.js * Data & Databases * PostgreSQL/PostGIS * Oracle Spatial * NoSQL Databases * Enterprise Data Services * Cloud & DevSecOps * AWS * Azure * Google Cloud * Kubernetes * Containerized Architectures * CI/CD Pipelines * Automated Testing Frameworks * Geospatial Technologies * GIS Applications * Geospatial Data Services * Open Geospatial Consortium (OGC) Standards * Web Map Services (WMS) * Web Feature Services (WFS) Preferred qualifications * Experience with cloud-native application development * Experience supporting Intelligence Community or Department of Defense missions * Experience with geospatial systems, GIS platforms, or GEOINT workflows * Experience with microservices architectures and container orchestration * Experience implementing automated security and compliance testing * Certified Scrum Master (CSM), PMI-ACP, or other Agile certifications * Experience supporting highly scalable enterprise applications

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