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Senior Python Developer Jobs in Wilmington, DE (NOW HIRING)

Ampcus Inc

Sr. Software Engineer

Wilmington, DE · On-site

$118K - $156K/yr

... DevOps teams to automate CI/CD pipelines on AWS. Qualifications : Required : • Strong proficiency in Java and Python programming languages. • Hands-on experience with AWS services (EC2, S3 ...

Vangard, Inc.

Senior AI/ML Engineer

Malvern, PA · On-site

$102K - $140K/yr

Collaborate with senior engineers and data scientists in feature development, experiments, and ... Solid Python programming skills and familiarity with ML frameworks (TensorFlow, PyTorch, scikit ...

Vangard, Inc.

Senior AI/ML Engineer

Philadelphia, PA · On-site

$105K - $144K/yr

Collaborate with senior engineers and data scientists in feature development, experiments, and ... Solid Python programming skills and familiarity with ML frameworks (TensorFlow, PyTorch, scikit ...

Vanguard Group, Inc.

Senior AI/ML Engineer

Malvern, PA · On-site

$102K - $140K/yr

Collaborate with senior engineers and data scientists in feature development, experiments, and ... Solid Python programming skills and familiarity with ML frameworks (TensorFlow, PyTorch, scikit ...

360 IT Professionals

Sr Java Developer

Wilmington, DE

$55.50 - $70.75/hr

Role:- Sr Java Developer Location:- Wilmington, DE. Duration:- 1 Year (Possible Extension) Sr Java ... C/C++, C#, Python, PHP, Ruby, Perl, etc. Experience working with Databases, SQL and Stored ...

TiltEdge Solutions LLC

Software Engineer

Malvern, PA · On-site

$50/hr

Senior Software Engineer (Python / Front-End / AWS) Location: Malvern, PA (Remote / Hybrid). Duration: 6-12 Months Rate: DOE : Role Overview: We are seeking a Senior Software Engineer with deep ...

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All JobsPython Developer JobsSenior Python Developer JobsSenior Python Developer Jobs in Wilmington, DE

Senior Python Developer information

See Wilmington, DE salary details

$53.4K

$137.8K

$189.2K

How much do senior python developer jobs pay per year?

As of Sep 13, 2026, the average yearly pay for senior python developer in Wilmington, DE is $137,768.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,900.00 and $158,700.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a senior Python developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What are the key skills and qualifications needed to thrive as a senior Python developer?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by senior Python developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

Are senior Python developers still in demand?

Senior Python developers remain in high demand due to the language's versatility in web development, data analysis, machine learning, and automation. Companies seek experienced developers with skills in frameworks like Django or Flask, and proficiency in cloud platforms and APIs enhances job prospects.

How much does a senior Python developer make?

A senior Python developer typically earns between $100,000 and $150,000 annually, depending on experience, location, and industry. They often possess strong skills in frameworks like Django or Flask and may hold certifications or advanced degrees that influence salary levels.

What does a senior Python developer do?

A senior Python developer designs, develops, and maintains complex software applications using Python. They often lead projects, review code, optimize performance, and collaborate with cross-functional teams, requiring strong problem-solving skills and knowledge of frameworks like Django or Flask. Additionally, they may mentor junior developers and ensure code quality through testing and best practices.

What are the most commonly searched types of Python Developer jobs in Wilmington, DE?

The most popular types of Python Developer jobs in Wilmington, DE are:

What are popular job titles related to Senior Python Developer jobs in Wilmington, DE?

For Senior Python Developer jobs in Wilmington, DE, the most frequently searched job titles are:

What job categories do people searching Senior Python Developer jobs in Wilmington, DE look for?

The top searched job categories for Senior Python Developer jobs in Wilmington, DE are:

What cities near Wilmington, DE are hiring for Senior Python Developer jobs?

Cities near Wilmington, DE with the most Senior Python Developer job openings:

Senior Python Developer jobs near you
Infographic showing various Senior Python Developer job openings in Wilmington, DE as of September 2026, with employment types broken down into 100% Full Time. Highlights an 67% In-person, and 33% Remote job distribution, with an average salary of $137,768 per year, or $66.2 per hour.

AI Engineer (Agentic AI) - Hybrid/Remote- 6 months

Exton, PA • On-site

Palni Inc
See more jobs at Palni Incexternal

Other

Posted 9 days ago

Job description

AI Engineer (Agentic AI)
Location: Exton, PA (HQ) ·
Work Mode: Hybrid and Open to Remote for senior candidates
Type: 6 Months
 
Job Summary
We are looking for AI Engineer (Agentic AI) to build and deploy production-grade AI agents for healthcare decision workflows.
The ideal candidate will have strong production Python experience, hands-on expertise with agentic AI and RAG systems, and the ability to work directly with healthcare stakeholders.
 
This role is focused on building, evaluating, and deploying AI systems that operate reliably in real-world environments.
 
Key Responsibilities
  • Design and build multi-agent workflows, agent graphs, and orchestration systems for healthcare use cases.
  • Develop production RAG pipelines over clinical, regulatory, and structured data sources.
  • Build evaluation frameworks, regression suites, and quality gates for AI systems.
  • Implement deterministic guardrails, human-in-the-loop workflows, and failure-handling mechanisms.
  • Develop production services using Python, FastAPI, PostgreSQL, and vector databases.
  • Work with clinical reviewers, medical directors, payer teams, and customer engineering teams to improve AI outcomes.
  • Own the end-to-end delivery of AI solutions from development through production.
  • Use Claude and other AI coding tools effectively across development, testing, and documentation.
Required Skills
  • Hands on experience in production software engineering experience.
  • Hands on experience in building and deploying LLM or ML systems in production.
  • Strong Python development experience.
  • Hands-on experience with agentic AI, multi-agent systems, or production orchestration frameworks.
  • Strong experience with RAG, retrieval evaluation, reranking, and citation traceability.
  • Experience building AI evaluation frameworks and quality gates.
  • Experience with FastAPI, async Python, PostgreSQL, and vector databases such as pgvector or ChromaDB.
  • Strong understanding of prompt engineering, structured outputs, tool calling, and context management.
  • Strong communication and customer-facing skills.
Nice-to-Have Skills
  • LangGraph, LangChain, DSPy, or Temporal.
  • Fine-tuning, LoRA, distillation, or preference optimization.
  • Open-weight inference using vLLM, Ollama, or llama.cpp.
  • Vision-language models and document extraction.
  • MCP server development or Claude Skills.
  • FHIR, X12 278, NCPDP SCRIPT, or healthcare interoperability experience.
  • Azure Government, AWS GovCloud, sovereign, or air-gapped deployments.
  • Anthropic Claude API or Claude Code experience at production scale.
  • Healthcare domain knowledge is preferred: CPT, ICD-10, HCPCS, NCD/LCD, medical necessity criteria, and PHI handling.

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