1

Senior Python Developer Jobs in Columbia, SC (NOW HIRING)

Job Purpose The Senior Finance AI & Automation Developer's primary responsibilities are to design ... Experience with Python and/or other code languages required * 6 Sigma Black Belt certification ...

We are seeking a Senior Network Engineer to support and enhance a large-scale enterprise networking ... Terraform, Python, or similar automation frameworks used to streamline network deployment ...

Senior Technical Product Owner

Columbia, SC · On-site

$117K - $154K/yr

Industry/Sector Not Applicable Specialism Software Engineering Management Level Senior Associate ... Working knowledge of Java, Python, and C++ to guide effectively engineering discussions and ...

As a Senior Associate, you will build meaningful client connections and learn how to manage and ... Azure DevOps Server - Utilizing Python and Terraform for infrastructure automation - Managing ...

May serve as senior technical staff member for assigned projects. May coach more junior technical ... Extensive knowledge in using programming languages such as Javascript, HTML, XML, PHP, Python ...

Senior Site Reliability Engineer

North, SC · On-site

$53 - $70.25/hr

... DevOps, or equivalent role operating production services at scale. * Strong Kubernetes experience ... Scripting proficiency (Python, Bash) for automation. * Experience with 24/7 on-call rotations.

Senior Solutions Architect - AMER We're a global team of over 400 people, working together to push ... Fluency in one or more programming languages, such as Java, Python, Go or Ruby * Strong ability to ...

New

Senior Product Manager

North, SC · On-site

$117K - $155K/yr

We build Develocity, the context-engineering layer for AI-driven software delivery used by some of ... Python, with support for additional build tools coming soon. We are an AI-native company. AI is not ...

Senior Technical Incident Manager

Columbia, SC · On-site

$105K - $144K/yr

... or Python is beneficial DESIRED SKILLS • AWS Certified Cloud Practitioner or AWS Certified ... Engineering, or a related field (or equivalent professional experience) CGI is required by law in ...

Showing results 21-40

Senior Python Developer information

See Columbia, SC salary details

$44.9K

$115.9K

$159.2K

How much do senior python developer jobs pay per year?

As of Aug 13, 2026, the average yearly pay for senior python developer in Columbia, SC is $115,930.00, according to ZipRecruiter salary data. Most workers in this role earn between $99,200.00 and $133,500.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a senior Python developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

How much does a senior Python developer make?

A senior Python developer's salary typically ranges from $100,000 to $150,000 annually, depending on experience, location, and industry. They often possess strong skills in frameworks like Django or Flask and may have certifications or experience with cloud platforms, which can influence compensation.

What are the key skills and qualifications needed to thrive as a senior Python developer?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by senior Python developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.
What are the most commonly searched types of Python Developer jobs in Columbia, SC? The most popular types of Python Developer jobs in Columbia, SC are:
What are popular job titles related to Senior Python Developer jobs in Columbia, SC? For Senior Python Developer jobs in Columbia, SC, the most frequently searched job titles are:
What job categories do people searching Senior Python Developer jobs in Columbia, SC look for? The top searched job categories for Senior Python Developer jobs in Columbia, SC are:
What cities near Columbia, SC are hiring for Senior Python Developer jobs? Cities near Columbia, SC with the most Senior Python Developer job openings:
Infographic showing various Senior Python Developer job openings in Columbia, SC as of August 2026, with employment types broken down into 2% Internship, 83% Full Time, 9% Part Time, and 6% Contract. Highlights an 80% Physical, 6% Hybrid, and 14% Remote job distribution, with an average salary of $115,930 per year, or $55.7 per hour.

Senior Software Engineer Applied AI

Advanced Monitored Caregiving Inc.

Columbia, SC • Remote

$113K - $149K/yr

Full-time

Posted 29 days ago


Job description

Senior Software Engineer: Applied AI (Voice Agents & ML Systems)

AMC Health · Remote (US) · Full-time

The pitch

We build and operate production AI voice agents that hold real phone conversations in a regulated healthcare setting, plus the machine learning and LLM pipelines around them. This is one seat that spans four disciplines that rarely come together: real-time systems, LLM engineering, traditional machine learning, and serious cloud infrastructure, all in production, all with real consequences. If you are the kind of engineer who gets restless doing one thing, this role is the opposite problem.

What you'll work across

Real-time voice AI

  • Streaming, low-latency speech-to-speech systems built on modern LLMs
  • Telephony and real-time media (call control, live audio streaming)
  • Audio handling and the quirks of real human conversation (interruptions, timing, noise)
  • Concurrency on a latency-sensitive path, where p99 matters and a stall is something a caller hears

LLM engineering

  • Wrapping nondeterministic models in deterministic control so they behave reliably in production
  • Multi-model pipelines, prompt design, and cost/latency budgeting
  • Evaluation harnesses, including LLM-as-judge and automated agent-tests-agent approaches
  • Agentic tooling that gives AI systems safe, structured access to infrastructure

Traditional (non-LLM) machine learning

  • End-to-end ML pipelines: feature engineering, model training, and scheduled inference
  • Imbalanced, messy real-world data; calibration and explainability for non-technical consumers
  • Turning research notebooks into reproducible, auditable production pipelines

Cloud and infrastructure

  • Infrastructure as code across multiple environments (we run on AWS)
  • Managed compute, data, streaming, and orchestration services
  • Security engineering in a regulated setting: encryption, least-privilege access, strict data-handling discipline
  • Observability and telemetry-driven debugging, tracing a production issue from a metric anomaly to root cause

Plus occasional full-stack work on internal tools, and an engineering workflow that leans heavily on AI coding assistants, with human accountability for every change.

What you'll actually do

  • Ship and debug code on a live, real-time voice pipeline where latency and correctness are user-facing
  • Design control systems around LLMs: guardrails, budgets, watchdogs, safe fallbacks
  • Build and operate LLM evaluation and batch-analysis pipelines
  • Own traditional ML workflows from data to scheduled production inference
  • Trace production issues from a metric anomaly to root cause, including building the evidence when the cause is a vendor

Must-haves

  • 7+ years building and operating production backend systems, with strong general-purpose programming skills (we work primarily in Python)
  • Experience running distributed systems in the cloud; comfortable debugging from telemetry to root cause
  • Hands-on production experience with LLMs or generative AI (any provider or framework), plus the judgment to know when not to use a model
  • Working fluency across the traditional machine learning lifecycle (you productionize; you do not need to publish)
  • Disciplined in a regulated environment: small, reviewable changes and careful handling of sensitive data

Nice-to-haves

  • Real-time media or telephony experience
  • Front-end / full-stack ability
  • ML pipeline experience, vector search, or embeddings
  • Fluency with AI coding assistants (our workflows assume them, with human accountability for every change)

How we work

Smallest correct change wins. Every behavior change is validated against the live system. Evidence over opinion in debugging. Code review is rigorous. Safety and privacy gate everything.

Work authorization (no exceptions)

This role is open only to US citizens and lawful permanent residents (Green Card holders). We cannot consider candidates who require visa sponsorship now or in the future, and we are unable to make exceptions of any kind.

How to apply

Please submit both of the following:

  • Your LinkedIn profile URL
  • A phone number where we can reach you

A resume is welcome but optional; the two items above are required.