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$59.5K

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How much do senior operational technology engineer jobs pay per year?

As of May 28, 2026, the average yearly pay for senior operational technology engineer in the United States is $126,557.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,500.00 and $143,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Operational Technology Engineer, and why are they important?

To thrive as a Senior Operational Technology Engineer, you need deep expertise in industrial control systems, network security, and automation, typically supported by a degree in engineering or a related field. Proficiency with SCADA, PLC programming, OT/IT integration platforms, and relevant certifications such as CISSP or ISA/IEC 62443 is often required. Strong problem-solving, communication, and leadership skills help in managing cross-functional teams and ensuring seamless operations. These competencies are vital to maintain secure, efficient, and resilient industrial environments in increasingly connected infrastructures.

How does a Senior Operational Technology Engineer typically collaborate with IT and OT teams to ensure system reliability?

A Senior Operational Technology Engineer plays a crucial role in bridging the gap between IT (Information Technology) and OT (Operational Technology) teams. They regularly coordinate with IT professionals to align cybersecurity protocols and network standards, while working closely with OT specialists to maintain and optimize industrial control systems. Effective communication and cross-disciplinary teamwork are key, as they often lead troubleshooting sessions, oversee system integrations, and ensure both safety and uptime. This collaborative environment helps maintain reliable, secure, and efficient operations throughout the organization.

What are Senior Operational Technology Engineers?

Senior Operational Technology (OT) Engineers are experienced professionals who design, implement, and maintain the systems that control and monitor industrial operations, such as manufacturing, energy, or utilities. They specialize in integrating hardware and software solutions to ensure the reliability, efficiency, and security of industrial control systems like SCADA and PLCs. In addition to technical expertise, they often lead teams, coordinate with IT departments, and ensure compliance with safety and cybersecurity standards. Their work is crucial for minimizing downtime, optimizing processes, and protecting critical infrastructure.
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What cities are hiring for Senior Operational Technology Engineer jobs? Cities with the most Senior Operational Technology Engineer job openings:
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Senior Operational Technology Engineer jobs near you
Infographic showing various Senior Operational Technology Engineer job openings in the United States as of May 2026, with employment types broken down into 95% Full Time, 1% Part Time, and 4% Contract. Highlights an 80% Physical, 9% Hybrid, and 11% Remote job distribution, with an average salary of $126,557 per year, or $60.8 per hour.
Senior Operational Technology Engineer

Senior Operational Technology Engineer

Cellares

South San Francisco, CA • On-site

$125.50K - $172.30K/yr

Full-time

Posted 12 days ago

Job description

Job Summary:
Cellares is the first Integrated Development and Manufacturing Organization (IDMO) focused on mass manufacturing cell therapies. The Senior Operational Technology Engineer will lead and support IT/OT operations in a global cell therapy manufacturing lab environment, ensuring system reliability, scalability, and regulatory compliance across multiple sites.
Responsibilities:
• Manage and deliver OT systems and technology for the company’s industrial and cell manufacturing environments
• Own and maintain a robust OT roadmap, including project objectives, prioritization, and implementation plans
• Ensure OT production environments adhere to security best practices and comply with relevant regulations
• Provide hands-on technical support and troubleshooting for production-related OT/IT issues, ensuring minimal disruption to 24x7 operations
• Implement and monitor OT production systems to guarantee 24x7 uptime and reliability, including network, server, biotech manufacturing lab, and proprietary equipment
• Develop and deliver training programs for new OT staff relating to production environment
• Contribute to creating, maintaining SOPs, Policies, and Process
• Lead and support GMP-related activities, including change control, system validation, qualification (IQ/OQ/PQ), and audit readiness
• Own OT access management processes, including user provisioning, role-based access control, and periodic access reviews to ensure compliance with GxP, data integrity, and cybersecurity requirements
• Ensure compliance with industry regulations, standards, and best practices related to OT and data security
• Provide backup support to Corporate IT as needed to ensure continuity of enterprise IT services
Qualifications:
Required:
• Bachelor's Degree in related field or proper training
• 7+ years of relevant experience
• Proven experience in IT management with a manufacturing or industrial setting, with a strong focus on 24x7 operational support
• Experience with monitoring, server management, and cybersecurity best practices
• Experience with Fortigate firewalls, Hirschmann industrial switches, lab and warehouse equipment
• Experience with various applications such as Nutanix Prism, SharePoint, and JIRA
• Experience working in a biotech regulated environment
• Knowledge of and experience with current Good Manufacturing Practices (cGMP) required
• Ability to independently prioritize work and deliver results effectively in a fast-paced environment.
• Ability to be a strong problem-solving skills and the ability to work under pressure
• Requires availability for on-call support and extended hours during critical system issues to maintain 24x7 operations
• Self-awareness, integrity, authenticity, and a growth/entrepreneurial mindset
Company:
Cellares is an Integrated Development and Manufacturing Organization dedicated to the automated, large-scale production of cell therapies. Founded in 2019, the company is headquartered in South San Francisco, USA, with a team of 201-500 employees. The company is currently Growth Stage.
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About Cellares

Sourced by ZipRecruiter

Industry

Pharmaceutical and medicine manufacturing

Company size

11 - 50 Employees

Headquarters location

South San Francisco, CA, US

Year founded

2019

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