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Senior Machine Learning Software Engineer Jobs (NOW HIRING)

About the Opportunity We are seeking a senior machine learning software engineer to design, build, deploy, monitor, and optimize production-ready ML services in regulated healthcare. You will work ...

Sr. Machine Learning Software Engineer

Denver, CO ยท On-site +1

$126.10K - $166.20K/yr

About the Opportunity We are seeking a senior machine learning software engineer to design, build, deploy, monitor, and optimize production-ready ML services in regulated healthcare. You will work ...

Sr. Machine Learning Software Engineer

Denver, CO ยท On-site

$126.10K - $166.20K/yr

About the Opportunity We are seeking a senior machine learning software engineer to design, build, deploy, monitor, and optimize production-ready ML services in regulated healthcare. You will work ...

Sr. Machine Learning Software Engineer

Denver, CO ยท On-site +1

$126.10K - $166.20K/yr

About the Opportunity We are seeking a senior machine learning software engineer to design, build, deploy, monitor, and optimize production-ready ML services in regulated healthcare. You will work ...

Sr Machine Learning Engineer

Orlando, FL ยท On-site

$114.40K - $150.80K/yr

Job Posting Title: Sr Machine Learning Engineer Req ID: 10142996 Department Description: At Disney ... This role combines deep expertise in machine learning, AI technology, software engineering, and ...

Sr Machine Learning Engineer

Burbank, CA ยท On-site

$131K - $172.80K/yr

Job Posting Title: Sr Machine Learning Engineer Req ID: 10142996 Department Description: At Disney ... This role combines deep expertise in machine learning, AI technology, software engineering, and ...

Sr Machine Learning Engineer

Seattle, WA ยท On-site

$139.40K - $183.80K/yr

Job Posting Title: Sr Machine Learning Engineer Req ID: 10142996 Department Description: At Disney ... This role combines deep expertise in machine learning, AI technology, software engineering, and ...

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Senior Machine Learning Software Engineer information

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$75.5K

$143.3K

$192K

How much do senior machine learning software engineer jobs pay per year?

As of May 28, 2026, the average yearly pay for senior machine learning software engineer in the United States is $143,292.00, according to ZipRecruiter salary data. Most workers in this role earn between $122,500.00 and $161,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Machine Learning Software Engineer, and why are they important?

A Senior Machine Learning Software Engineer requires deep expertise in machine learning algorithms, statistical analysis, and strong programming skills in languages like Python or Java, typically supported by a degree in computer science or a related field. Familiarity with frameworks such as TensorFlow, PyTorch, scikit-learn, as well as experience with cloud platforms and version control systems, is standard. Exceptional problem-solving, leadership, and communication skills help drive project success and mentor junior engineers. These competencies are crucial for designing scalable ML solutions, ensuring code quality, and effectively collaborating within cross-functional teams.

What are some common challenges Senior Machine Learning Software Engineers face when deploying models to production?

Senior Machine Learning Software Engineers often encounter challenges such as ensuring model scalability, maintaining performance under real-world data conditions, and integrating models seamlessly with existing systems. Handling data drift and monitoring model predictions for accuracy over time are also critical responsibilities. Collaboration with data engineers, DevOps, and product teams is essential to address these challenges and ensure robust, reliable deployments.

What is a Senior Machine Learning Software Engineer?

A Senior Machine Learning Software Engineer is an experienced professional who designs, develops, and deploys machine learning models and systems to solve complex problems. They work closely with data scientists, engineers, and other stakeholders to build scalable and efficient solutions that leverage large data sets and advanced algorithms. Their responsibilities often include architecting ML pipelines, optimizing model performance, and mentoring junior team members. Typically, they have a strong background in computer science, programming, and applied mathematics, along with several years of hands-on experience in machine learning and software engineering.

What is the difference between Senior Machine Learning Software Engineer vs Data Scientist?

AspectSenior Machine Learning Software EngineerData Scientist
CredentialsBachelor's or Master's in CS, ML, or related; experience with ML frameworksBachelor's or Master's in Data Science, Statistics, or related; strong analytical skills
Work EnvironmentDevelops ML models, integrates algorithms into products, collaborates with engineering teamsAnalyzes data, builds statistical models, visualizes insights, collaborates with business teams
Industry UsageTech, finance, healthcare, e-commerceResearch, finance, marketing, healthcare

While both roles involve working with data and algorithms, Senior Machine Learning Software Engineers focus on developing and deploying scalable ML models within software systems, whereas Data Scientists primarily analyze data to generate insights and inform business decisions.

More about Senior Machine Learning Software Engineer jobs
What cities are hiring for Senior Machine Learning Software Engineer jobs? Cities with the most Senior Machine Learning Software Engineer job openings:
What are the most commonly searched types of Machine Learning Software Engineer jobs? The most popular types of Machine Learning Software Engineer jobs are:
What states have the most Senior Machine Learning Software Engineer jobs? States with the most job openings for Senior Machine Learning Software Engineer jobs include:
Infographic showing various Senior Machine Learning Software Engineer job openings in the United States as of May 2026, with employment types broken down into 1% As Needed, 95% Full Time, 3% Part Time, and 1% Contract. Highlights an 80% Physical, 4% Hybrid, and 16% Remote job distribution, with an average salary of $143,292 per year, or $68.9 per hour.

Senior Machine Learning Software Engineer

Pennsylvania Medicine

Philadelphia, PA โ€ข On-site

$123.60K - $163K/yr

Other

This job post hasย expired today.ย Applications are no longer accepted.


Job description

Senior Machine Learning Software Engineer

Penn Medicine is dedicated to our tripartite mission of providing the highest level of care to patients, conducting innovative research, and educating future leaders in the field of medicine. Working for this leading academic medical center means collaboration with top clinical, technical and business professionals across all disciplines. Today at Penn Medicine, someone will make a breakthrough. Someone will heal a heart, deliver hopeful news, and give comfort and reassurance. Our employees shape our future each day. Are you living your life's work?

Entity: Corporate Services

Department: PennDNA Data Science

Location: 3600 Civic Center Blvd, Philadelphia, PA

Hours: M-F, Daylight

Summary: Working with a team of data scientists and ML engineers, the Senior Machine Learning Software Engineer is responsible for the development, implementation, and maintenance of cutting-edge software for machine learning models and algorithms. The goal is to drive impactful insights and solutions across various healthcare domains, such as enhancing patient care, operational efficiency, and research endeavors. The ideal candidate will be a seasoned software engineer with experience in machine learning infrastructure and healthcare data. The Senior ML Software Engineer is both a member of a team, has expertise in one or more sub-domains, triages and refines requests, leads moderately complex projects and mentors more junior members of the team.

Responsibilities:

  • Systems and Software Engineering: Leverage proprietary and open-source tools and frameworks to develop ML systems and software applications. Design and implement scalable and modular software architectures, emphasizing maintainability and extensibility. Develop core capabilities for ML training, development, deployment and monitoring. Develop integrations with health system applications (e.g. Epic), systems and both on-prem and cloud infrastructure. Responsible for continuous integration and continuous delivery of production code. Independently lead and execute moderately complex projects with minimal oversight.
  • Model Deployment and Monitoring: Develop and enforce the technical standards for deployment of machine learning models for healthcare applications. Contribute to the deployment and monitoring of ML capabilities based on emerging technologies, trends and methodologies. Lead the design and development of tools for active monitoring of models and ML applications. Help maintain and optimize production models and applications.
  • Data Sourcing and Integration: Work with ML and data engineers to build robust and maintainable data pipelines for model development, validation, and deployment. Ensure seamless data integration and flow with health system applications that supports the scalability and efficiency of ML models and analytics platforms.
  • Collaboration: Collaborate with a multidisciplinary team, including data scientists, data and ML engineers, clinicians, administrators, and product managers to define project requirements and develop solutions that meet organizational needs. This collaboration aims not only to advance healthcare technology but also to drive significant improvements in patient outcomes and operational efficiencies, demonstrating the tangible impact of our work. Provide subject matter expert review, guidance and consultation.
  • Continuous Improvement: Demonstrate a commitment to continuous learning and professional development. Stay current with emerging industry trends, best practices, and technologies in ML software engineering. Model a culture of performance excellence both within team and across the enterprise. Look for opportunities to optimize the team's processes and workflows.

Education or Equivalent Experience:

  • Bachelor's degree is required. Computer science or a related field with a focus on machine learning or data science.
  • 3+ years of experience and expertise in software engineering and infrastructure to support development and deployment of machine learning models and applications is required.
  • Proven track record of leading and executing moderately complex projects with minimal oversight is required.
  • 1+ years healthcare analytics experience is preferred.

We believe that the best care for our patients starts with the best care for our employees. Our employee benefits programs help our employees get healthy and stay healthy. We offer a comprehensive compensation and benefits program that includes one of the finest prepaid tuition assistance programs in the region. Penn Medicine employees are actively engaged and committed to our mission. Together we will continue to make medical advances that help people live longer, healthier lives. Live Your Life's Work

We are an Equal Opportunity employer. Candidates are considered for employment without regard to race, ethnicity, color, sex, sexual orientation, gender identity, religion, national origin, ancestry, age, disability, marital status, familial status, genetic information, domestic or sexual violence victim status, citizenship status, military status, status as a protected veteran or any other status protected by applicable law.