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Senior Instrument Engineer Jobs in Missouri (NOW HIRING)

Louis, MO We are looking for a mid to senior Software Engineer to design, build, and operate ... Instrument and monitor services using observability tooling (for example Datadog), improving ...

Software Engineer

Saint Louis, MO · On-site +1

$100K/yr

Louis, MO We are looking for a mid to senior Software Engineer to design, build, and operate ... Instrument and monitor services using observability tooling (for example Datadog), improving ...

Software Engineer

Saint Louis, MO · On-site +1

$100K/yr

Louis, MO We are looking for a mid to senior Software Engineer to design, build, and operate ... Instrument and monitor services using observability tooling (for example Datadog), improving ...

Software Engineer

Saint Louis, MO · On-site +1

$100K/yr

Louis, MO We are looking for a mid to senior Software Engineer to design, build, and operate ... Instrument and monitor services using observability tooling (for example Datadog), improving ...

Software Engineer

Saint Louis, MO · On-site +1

$100K/yr

Louis, MO We are looking for a mid to senior Software Engineer to design, build, and operate ... Instrument and monitor services using observability tooling (for example Datadog), improving ...

Software Engineer

Saint Louis, MO · On-site +1

$100K/yr

Louis, MO We are looking for a mid to senior Software Engineer to design, build, and operate ... Instrument and monitor services using observability tooling (for example Datadog), improving ...

... and Engineering Services Job Summary: The I&E Maintenance Technician provides technical skill, knowledge and guidance to execute Instrument and Electrical (I&E) maintenance and supports Sr. ...

New

Sr. Field Technician

Kansas City, MO

$18.25 - $25/hr

Electric Power Systems (EPS) is a NETA-accredited independent electrical testing and engineering ... grounding, instrument transformers, and variance of switches both manual and motor operated.

Perform scheduled instrument calibrations to ensure accurate, precise, and repeatable results ... Bachelor's degree in chemistry or chemical engineering. * Five to Seven (5-7) years of experience ...

Sr. Field Technician

Kansas City, MO · On-site

$18.25 - $25/hr

Electric Power Systems (EPS) is a NETA-accredited independent electrical testing and engineering ... grounding, instrument transformers, and variance of switches both manual and motor operated.

Showing results 21-40

Senior Instrument Engineer information

See Missouri salary details

$74.1K

$109.6K

$154.8K

How much do senior instrument engineer jobs pay per year?

As of Aug 8, 2026, the average yearly pay for senior instrument engineer in Missouri is $109,595.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,200.00 and $128,500.00 per year, depending on experience, location, and employer.

What are some common challenges faced by senior instrument engineers when working on multidisciplinary projects?

Senior Instrument Engineers often encounter challenges coordinating with other engineering disciplines, such as process, electrical, and mechanical teams, to ensure instrumentation specifications align with overall project requirements. Integrating new instrumentation technologies into existing systems while maintaining compliance with safety and industry standards can also be demanding. Effective communication, strong project management skills, and adaptability are essential to successfully navigate these complexities and ensure project deliverables are met on time and within budget.

What does a senior instrument engineer do?

A Senior Instrument Engineer is responsible for designing, specifying, installing, and maintaining instrumentation and control systems used in industrial processes. They ensure that these systems function efficiently, safely, and reliably to monitor and control variables such as pressure, temperature, and flow. Senior Instrument Engineers often lead projects, troubleshoot complex issues, and provide technical guidance to junior engineers. They also collaborate with other engineering disciplines to optimize process performance and comply with industry standards.

What are the key skills and qualifications needed to thrive as a senior instrument engineer, and why are they important?

To thrive as a Senior Instrument Engineer, you typically need a degree in engineering (often electrical, instrumentation, or control engineering) and extensive experience with instrumentation design, installation, and maintenance. Proficiency with industry-standard tools such as PLCs, DCS, CAD software, and familiarity with relevant codes and certifications like ISA or IEC are essential. Strong problem-solving, project management, and communication skills help coordinate teams and interface with other engineering disciplines. These skills and qualities ensure the safe, efficient, and reliable operation of complex industrial processes.

What is the difference between Senior Instrument Engineer vs Instrument Technician?

AspectSenior Instrument EngineerInstrument Technician
CredentialsBachelor's degree in Engineering, certifications like CSE or ISATechnical diploma or associate degree, specialized training
Work EnvironmentDesign, project management, troubleshooting in industrial plantsInstallation, maintenance, calibration on-site
Industry UsageEngineering firms, oil & gas, manufacturingRefineries, power plants, process industries

While both roles involve instrumentation, the Senior Instrument Engineer focuses on design, planning, and troubleshooting at a higher level, often overseeing projects. The Instrument Technician handles hands-on installation, maintenance, and calibration tasks. Both roles are essential in industrial settings but differ in responsibilities and required qualifications.

What cities in Missouri are hiring for Senior Instrument Engineer jobs? Cities in Missouri with the most Senior Instrument Engineer job openings:
Infographic showing various Senior Instrument Engineer job openings in Missouri as of August 2026, with employment types broken down into 92% Full Time, 2% Part Time, and 6% Contract. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $109,595 per year, or $52.7 per hour.

$75K - $113K/yr

Full-time

Medical, Retirement, PTO

Posted 27 days ago


Job description

Work Location: St. Louis, Missouri
Shift: No
Department: LS-SC-UYKPEA Cherokee STL PAD Team 6 Group 1
Recruiter:Michelle Cole


This information is for internals only. Please do not share outside of the organization.


Your Role

In this Sr. Analytical Scientist role you will be involved with problem solving, working within project timelines, and contributing to documentation for method qualification and transfer into GMP manufacturing. Key responsibilities include the following:

  • Serve as a subject matter expert in analytical development, perform troubleshooting / provide efficient and innovative solutions, and support transfer of analytical methods to GMP QC labs
  • Utilize customer-facing skills, document experimental results, communicate results to all stakeholders, author method development and qualification documents, contribute to information for customer proposals
  • Serve as a project lead and ensure project deliverables are on quality and on time, develop multiple technical approach plans as needed to solve problems and mitigate risk, ensure process and methods are in place for efficient GMP start
  • Lead project teams, influence exemplary work in other team members, lead process improvement initiatives, scout for new technologies / emerging trends, proactively consider the impact of quality, regulatory, manufacturing, and safety requirements when planning project activities

Who You Are

Minimum Qualifications:

  • Bachelor's degree in chemistry, Biochemistry, Biomedical Engineering, Chemical Engineering or other Life Science or Engineering discipline and 6+ years of research in an industrial or post-graduate setting

OR

  • Master's degree in chemistry, Biochemistry, Biomedical Engineering, Chemical Engineering or other Life Science or Engineering discipline and 2+ years of research in an industrial or post-graduate setting

OR

  • PhD in Chemistry, Biochemistry, Biomedical Engineering, Chemical Engineering or other Life Science or Engineering discipline and 1+ years of research in an industrial or post-graduate setting

Preferred Qualifications:

  • Experience with protein characterization via ELISA, SPR, Isoelectric Focusing, CE-based methods, UV-Vis, and/or chromatography (HPLC/GC/IC/UPLC/SEC/HILIC)
  • Experience with advanced laboratory techniques; theory and practice to enable the development of novel approaches to solve complex process and analytical problems on fast-paced projects with changing priorities
  • Knowledge of small molecule or bio-therapeutics drug development process
  • Experience with antibody-drug conjugation
  • Knowledge in Biochemistry or Organic Chemistry
  • Experience in automation in analytical settings and instrument maintenance and troubleshooting
  • Knowledge of Microsoft Word, Excel, and PowerPoint
  • Experience with advanced data acquisition and/or statistical software systems
  • Ability to coordinate information exchange and manage data generated by contract testing labs

Pay Range for this position: $75,700 - $113,500 annually

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information clickhere.


The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law. This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

Employment Type: FULL_TIME