Senior Instrument Engineer Jobs in British Columbia

Molecular You is redefining what it means to know your health. Our precision multi-omic platform generates deep molecular profiles that help people and their clinicians take meaningful, proactive action. As a Senior Mass Spectrometry Scientist, you will be a technical cornerstone of our analytical laboratory-developing, validating, performing, and overseeing clinical multi-omic assays that underpin the absolute quantification workflows at the heart of our clinical operations.

This is a high-impact opportunity for a scientist who combines deep technical expertise with the discipline of a regulated clinical environment and is energized by translating rigorous analytical science into real-world health impact. You will own assay development from conception through ISO-compliant deployment, solve complex instrumentation and shape next-generation MS capabilities, and mentor junior scientists in best practices.

Key Responsibilities

Assay Development & Absolute Quantification

• Develop, optimize, and implement proprietary MRM-MS assays for targeted absolute quantification of proteins, lipids, metabolites, and other analytes across complex biological matrices (including plasma, serum, and potentially others).
• Execute full method validation packages in accordance with FDA Bioanalytical Method Validation guidance, CLIA and ISO 15189 frameworks.
• Develop, update, and maintain SOPs that support robust, reproducible, and audit-ready laboratory workflows.
• Develop technical and training transfer packages that enable partner laboratories to accurately and reproducibly run our assays in a clinical laboratory environment.
• Develop new MS-based technologies for integration into Molecular You's clinical multi-omic assay workflow.

Instrumentation & Troubleshooting

• Serve as a subject matter expert for LC-MS/MS platforms (e.g., Agilent, Sciex, Thermo, Waters), including source optimization, ion-pair selection, chromatographic troubleshooting, and scheduled MRM configuration.
• Lead systematic troubleshooting of assay failures, matrix interference, ion suppression, and carryover issues, escalating findings and implementing permanent corrective actions.
• Maintain instrument qualification (IQ/OQ/PQ) records and coordinate preventative maintenance schedules with vendors in accordance with laboratory SOPs.

Clinical Laboratory Operations

• Operate within a regulated clinical laboratory (ISO 15189 or equivalent) environment, maintaining strict adherence to SOPs, chain-of-custody protocols, and sample integrity requirements.
• Partner with the laboratory director and QA/QC team to prepare, maintain, and execute documentation required for ISO accreditation, proficiency testing, and external audits.
• Ensure all assay workflows are audit-ready, including instrument logs, reagent traceability, QC charts, and deviation records.

Data Analysis & Scientific Communication

• Perform and review quantitative data analysis using software platforms such as MassHunter, Skyline, or equivalent, ensuring accurate peak integration and batch review.
• Author high-quality technical reports, SOPs, and method transfer documents; present findings to cross-functional stakeholders including bioinformatics, product, and medical teams.
• Contribute to peer-reviewed publications and support intellectual property activities as applicable.

Mentorship & Collaboration

• Mentor and coach junior scientists and laboratory technicians in MRM-MS principles, laboratory operations, and quantitative method development.
• Collaborate with bioinformaticians, data scientists, and software engineers to integrate MS data streams into Molecular You's broader multi-omic platform.
• Support procurement and capital equipment decisions for next-generation mass spectrometry infrastructure.

Qualifications

Required

• PhD. in Analytical Chemistry, Biochemistry, Proteomics, Metabolomics, or a closely related field; or M.Sc. with 5+ years of directly relevant industry experience.
• 5+ years of hands-on experience developing and validating quantitative MRM-MS assays in a professional laboratory setting.
• Demonstrated expertise in absolute quantification by LC-MS/MS using stable isotope-labeled internal standards and external calibration curves.
• Deep familiarity with at least one major LC-MS/MS vendor platform (Agilent, Sciex, Thermo Scientific, or Waters).
• Expertise in operating LC-MS/MS systems and using associated acquisition, processing, and method-development software.
• Proven ability to independently troubleshoot complex analytical problems across chromatography, ionization, and detection.
• Experience working with a laboratory information management system (LIMS).

Preferred

• Experience in a multi-omic or systems biology context, with exposure to proteomics, metabolomics, or lipidomics at a clinical or translational scale.
• Experience with clinical laboratory setup, launch, or scale-up.
• Familiarity with Skyline or similar open-source MRM data management and analysis tools.
• Direct experience working in or supporting an ISO 15189-accredited or equivalent clinical or regulated analytical laboratory. Prior involvement in ISO accreditation drives, external laboratory audits, or regulatory submissions
• Experience with automated sample preparation platforms (e.g., Hamilton, Tecan) and their integration with MS workflows.
• Comfort working in a fast-paced, cross-functional environment where scientific rigor and operational agility are equally valued.
• A builder mindset: you enjoy creating robust analytical systems, improving how a laboratory operates, and collaborating across disciplines to turn complex science into scalable clinical impact.

What We Offer

Molecular You offers a collaborative, science-first environment where your work has a direct impact on how people understand and act on their health. You will join a team working at the leading edge of health and longevity, using multi-omic science to help move healthcare toward earlier, more precise, and more proactive action. In addition to competitive compensation and benefits, you will have access to a state-of-the-art analytical facility, a multidisciplinary team of scientists and engineers, and the opportunity to help build something genuinely new in precision health.

• Competitive salary commensurate with experience and qualifications.
• Extended health, dental, and vision benefits.
• Equity participation in a growth-stage company.
• Continuous learning budget and conference travel support.
• Flexible work environment with a collaborative, inclusive culture.

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