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Senior Full Stack Software Engineer Jobs in Columbus, OH

Huntington

Senior Full Stack Developer

Columbus, OH · On-site +1

$70K - $140K/yr

Senior Full Stack Developer - In this senior role, the successful candidate will Design, Develop ... Full SDLC experience with software development. * 3+ years of experience in developing REST APIs in ...

Huntington

Senior Full Stack Developer

Columbus, OH · On-site +1

$70K - $140K/yr

Senior Full Stack Developer - In this senior role, the successful candidate will Design, Develop ... Full SDLC experience with software development. * 3+ years of experience in developing REST APIs in ...

Staffingine LLC

Java Full Stack Developer

Columbus, OH · On-site

$50.75 - $65.50/hr

Java Full Stack Developer Job Location: Columbus, OH Job Type: Contract : * Java Full Stack ... Software Engineer should have general development skills, mainly in Java and JavaScript * General ...

Centraprise

Full Stack Java Developer

Columbus, OH · On-site

$49.50 - $63.75/hr

Hi, Title- Java Developer Location- Columbus, OH | Onsite Role- Contract We are seeking an experienced Senior Full Stack Java Developer with 12+ years of hands-on experience in designing, developing ...

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Senior Full Stack Software Engineer information

See Columbus, OH salary details

$43K

$130.2K

$184K

How much do senior full stack software engineer jobs pay per year?

As of Aug 9, 2026, the average yearly pay for senior full stack software engineer in Columbus, OH is $130,175.00, according to ZipRecruiter salary data. Most workers in this role earn between $107,200.00 and $152,600.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a senior full stack software engineer?

To thrive as a Senior Full Stack Software Engineer, you need deep expertise in both front-end and back-end development, strong problem-solving abilities, and a solid foundation in computer science principles, typically demonstrated by a bachelor’s or master’s degree in a related field. Familiarity with frameworks and languages like React, Angular, Node.js, Python, and proficiency in using cloud platforms, version control systems like Git, and continuous integration tools is crucial, and relevant certifications are an advantage. Exceptional communication, leadership, and teamwork skills help you effectively coordinate with cross-functional teams and mentor junior engineers. These skills ensure you can deliver robust, scalable solutions while driving project success and fostering a collaborative development environment.

What does a senior full stack software engineer do?

A typical day for a Senior Full Stack Software Engineer involves designing and implementing new features, reviewing and improving code, and collaborating with product managers, designers, and other developers to deliver project goals. You might split your time between writing code for both front-end and back-end systems, participating in daily stand-up meetings, and providing technical guidance to junior team members. The role often requires balancing hands-on development with architectural planning and problem-solving for complex technical challenges. You’ll also frequently interact with stakeholders to gather requirements and provide updates, ensuring alignment throughout the software development lifecycle.

What is a senior full stack software engineer?

A Senior Full Stack Software Engineer is an experienced developer responsible for designing, building, and maintaining both front-end and back-end systems in web or software applications. They work with a variety of technologies, frameworks, and databases to ensure seamless functionality across the entire software stack. In addition to coding, they often provide technical leadership, mentor junior developers, and contribute to architectural decisions. Their role requires strong problem-solving skills, an understanding of best practices, and the ability to collaborate with cross-functional teams to deliver high-quality software solutions.

What are the most commonly searched types of Full Stack Software Engineer jobs in Columbus, OH? The most popular types of Full Stack Software Engineer jobs in Columbus, OH are:
What are popular job titles related to Senior Full Stack Software Engineer jobs in Columbus, OH? For Senior Full Stack Software Engineer jobs in Columbus, OH, the most frequently searched job titles are:
What job categories do people searching Senior Full Stack Software Engineer jobs in Columbus, OH look for? The top searched job categories for Senior Full Stack Software Engineer jobs in Columbus, OH are:
What cities near Columbus, OH are hiring for Senior Full Stack Software Engineer jobs? Cities near Columbus, OH with the most Senior Full Stack Software Engineer job openings:
Senior Full Stack Software Engineer jobs near you
Infographic showing various Senior Full Stack Software Engineer job openings in Columbus, OH as of August 2026, with employment types broken down into 88% Full Time, 8% Part Time, and 4% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $130,175 per year, or $62.6 per hour.

Senior AI Full stack Software Engineer

McKesson Corporation

Columbus, OH • On-site

$131K - $218K/yr

Full-time

Re-posted 17 days ago

McKesson rating

7.9

Company rating: 7.9 out of 10

Based on 209 frontline employees who took The Breakroom Quiz

47th of 86 rated pharmaceutical

Job description

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve - we care.
What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow's health today, we want to hear from you.
We are seeking a highly skilled and experienced Senior AI Full Stack Software Engineer to join our innovative team at CMM. This role involves designing, developing, and deploying end-to-end AI-powered solutions, from robust backend services to intuitive user interfaces, to enhance our healthcare and decision-making platforms.
Key Responsibilities
  • Lead AI-Driven Healthcare Solutions: Design and deploy AI applications that support decision-making, patient engagement, and operational efficiency.
  • Integrate AI into EHRs and Clinical Systems: Build scalable systems that incorporate LLMs, voice/image recognition, and document parsing into existing healthcare IT infrastructure.
  • Develop and Optimize Data Pipelines: Ensure secure, HIPAA-compliant data pipelines for training and deploying AI models using structured and unstructured healthcare data (e.g., clinical notes, imaging, lab results).
  • Model Evaluation and Compliance: Apply rigorous evaluation metrics (e.g., sensitivity, specificity, AUC-ROC) and ensure models meet regulatory and ethical standards.
  • Mentor and Lead: Guide junior engineers and contribute to the strategic direction of AI initiatives within the organization.
  • Rapid AI prototyping and iteration with product representatives to vet multiple concepts

We are unable to provide sponsorship for this role presently or in the future.
Priority will be given to candidates who reside in the Columbus, OH and Atlanta, GA metropolitan area.
Minimum Qualifications
  • 10+ years of software engineering experience, with 4+ years in AI/ML development preferred.
  • B.S. degree in Computer Science or related engineering discipline, or equivalent experience

Critical Skills
  • 2+ years of experience building AI solutions in healthcare or life sciences.
  • Deep understanding of healthcare data standards (e.g., HL7, FHIR) and compliance frameworks (e.g., HIPAA, GDPR).
  • Healthcare AI Expertise: Proven ability to build AI models for clinical NLP, medical imaging, patient risk stratification, and care personalization.
  • LLM & RAG Systems: Skilled in building retrieval-augmented generation systems using tools like Pydantic, Semantic Kernel, LangChain, LlamaIndex, and vector databases.
  • Experienced in creating custom AI agents or spec-driven tools.
  • Experience writing skills for Claude, Copilot, Codex etc.
  • Prompt Engineering & Optimization: Advanced techniques for prompt tuning, caching, and benchmarking.
  • Full Stack Development: Proficiency in Python, Node.js, and modern web frameworks.

Preferred Skills
  • Cloud & DevOps: Experience with secure cloud environments (AWS/GCP/Azure), containerization (Docker, Kubernetes), and CI/CD pipelines.
  • AI Tooling: Familiarity with OpenAI, Hugging Face, PyDantic AI, TensorFlow, PyTorch, and healthcare-specific AI libraries.
  • Communication & Leadership: Ability to communicate complex AI concepts to clinical and executive stakeholders and lead cross-functional teams.
  • Experience mentoring and developing juniors in development an AI concepts/best practices.

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please click here.
Our Base Pay Range for this position
$131,000 - $218,300
McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson's (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:
McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.
McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.
McKesson job postings are posted on our career site: careers.mckesson.com.
McKesson is an Equal Opportunity Employer
McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson's full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.
McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) Disability_Accommodation@McKesson.com or (Canada) Accessibility@mckesson.ca. Resumes or CVs submitted to this email box will not be accepted.
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