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Senior Director Oncology Development information

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$39.5K

$142.9K

$279.5K

How much do senior director oncology development jobs pay per year?

As of Sep 11, 2026, the average yearly pay for senior director oncology development in the United States is $142,920.00, according to ZipRecruiter salary data. Most workers in this role earn between $101,500.00 and $161,000.00 per year, depending on experience, location, and employer.

What does a senior director oncology development do?

A Senior Director of Oncology Development leads and oversees the research, design, and execution of clinical development programs for cancer therapies within a pharmaceutical or biotechnology company. They are responsible for strategizing the development of oncology drugs from early research phases through clinical trials and regulatory submissions. This role involves collaborating with cross-functional teams, managing budgets and timelines, ensuring regulatory compliance, and engaging with key stakeholders such as regulatory agencies, investigators, and external partners. The Senior Director also provides scientific and medical leadership, guiding teams to bring innovative cancer treatments to market.

What are the key skills and qualifications needed to thrive as a senior director oncology development?

To thrive as a Senior Director Oncology Development, you need advanced expertise in oncology drug development, clinical trial management, and a strong scientific or medical background, often demonstrated by an advanced degree (MD, PhD, or PharmD). Familiarity with regulatory requirements (FDA, EMA), clinical data management systems, and project management tools is essential. Outstanding leadership, strategic thinking, and excellent communication skills help drive cross-functional teams and stakeholder engagement. These competencies are vital for successfully guiding oncology programs through complex development stages, ensuring regulatory compliance, and delivering impactful therapies to patients.

What are some common challenges faced by a senior director oncology development, and how can they be navigated?

Senior Directors in Oncology Development often encounter challenges such as balancing innovative clinical trial designs with regulatory requirements, managing cross-functional teams, and adapting to rapidly evolving scientific landscapes. Navigating these requires strong leadership, proactive communication with stakeholders, and a commitment to continuous learning. Building collaborative relationships with regulatory agencies, clinical investigators, and internal R&D teams is essential for overcoming hurdles and driving successful oncology programs forward.

What are popular job titles related to Senior Director Oncology Development jobs?

For Senior Director Oncology Development jobs, the most frequently searched job titles are:

Infographic showing various Senior Director Oncology Development job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $142,920 per year, or $68.7 per hour.

Senior Director, Clinical Development

Boston, MA • On-site

Tango Therapeutics
Biotechnology Research and Development • 11 - 50 employees
Learn more about Tango Therapeuticsexternal

Full-time

Re-posted 13 days ago

Key responsibilities

  • Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s).

  • Design, author, and oversee the development of study protocols, investigator brochures, and other key clinical documents in compliance with regulations and guidelines.

  • Serve as the primary clinical lead for study investigators and key opinion leaders, building relationships to support program success and scientific advancement.

Job description

Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Senior Director, Clinical Development will provide medical and scientific leadership for Tango's oncology development programs, driving clinical strategy from early-stage development through registration. Reporting to the President, Research & Development, this individual will lead cross-functional clinical teams, shape development plans, oversee study execution and medical monitoring, and serve as a key partner to investigators, regulators, and senior leadership.
This highly visible role combines strategic leadership with hands-on clinical development responsibilities and offers the opportunity to directly influence the advancement of innovative precision oncology therapies for patients. The Senior Director will build and maintain strong relationships with investigators, key opinion leaders (KOLs), and external partners while ensuring the successful execution of clinical studies and overall program objectives.
Your Role:
  • Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s), partnering with cross-functional teams to create and implement comprehensive clinical development plans
  • Provide leadership to the clinical team and serve as the medical and scientific expert for development programs
  • Design, author, and oversee the development of study protocols, protocol amendments, investigator brochures, and other key clinical documents in compliance with project plans, global regulations, ICH/GCP guidelines, and Good Medical Practice
  • Serve as the primary clinical lead for study investigators and key opinion leaders, building strong relationships that support program success and scientific advancement
  • Lead clinical contributions to regulatory submissions, including INDs, CTAs, NDA/MAA filings, and interactions with Health Authorities
  • Act as Medical Monitor and/or oversee external Medical Monitors for company-sponsored clinical trials, ensuring appropriate medical oversight and patient safety
  • Provide strategic oversight of adverse event review, safety monitoring, protocol compliance, and clinical data evaluation
  • Partner closely with Clinical Operations, Clinical Pharmacology, Biometrics, Regulatory Affairs, Drug Safety, Data Management, Quality, and Translational Sciences to ensure integrated and efficient execution of development programs
  • Analyze and interpret clinical trial data and communicate findings through regulatory submissions, scientific publications, medical congress presentations, and internal governance reviews
  • Lead responses to questions from Health Authorities, Ethics Committees, and Institutional Review Boards, ensuring consistency and scientific rigor
  • Contribute to portfolio strategy, development planning, and broader organizational initiatives as needed
  • Perform additional responsibilities as required to support the advancement of Tango's clinical programs

What You Bring:
  • MD required; board certification or board eligibility in Medical Oncology, Hematology/Oncology, or a related specialty strongly preferred
  • 5+ years of clinical development experience within the biotechnology and/or pharmaceutical industry, including experience leading oncology development programs
  • Demonstrated experience in the design, execution, interpretation, and reporting of oncology clinical trials involving targeted therapies, small molecules, and/or immuno-oncology agents
  • Experience supporting or leading late-stage clinical development programs, NDA/BLA/MAA submissions, and Health Authority interactions
  • Strong understanding of the biological and translational sciences underlying modern oncology drug development, including molecular biology, cancer genetics, immunology, and precision medicine approaches
  • Proven ability to lead and influence cross-functional teams within a matrixed organization
  • Excellent strategic thinking, organizational, and project leadership skills, with the ability to balance high-level planning and hands-on execution
  • Strong problem-solving skills and the ability to identify innovative approaches to advance development programs and organizational objectives
  • Exceptional communication and presentation skills, including the ability to engage effectively with senior leadership, investigators, KOLs, and regulatory agencies
  • Demonstrated leadership capabilities with a collaborative, team-oriented, and results-driven approach
  • Flexible, resourceful, and entrepreneurial mindset with the ability to thrive in a dynamic and fast-paced biotechnology environment

#LI-Hybrid
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Salary range
$274,400-$411,600 USD

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