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Senior Backend Python Jobs in South Carolina (NOW HIRING)

TRULEO

Senior Software Engineer

Greenville, SC · On-site

$115K - $151K/yr

Build and ship customer-facing features across the full stack (front end, back end, and data), and ... Experience with Python, machine learning (ML), ML Ops * Experience building AI-powered systems.

Truleo

Senior Software Engineer

Greenville, SC · On-site

$115K - $151K/yr

Build and ship customer-facing features across the full stack (front end, back end, and data), and ... Experience with Python, machine learning (ML), ML Ops * Experience building AI-powered systems.

Glsauto

Senior Automation Analyst

Greenville, SC · On-site

Evaluate AI platforms, agent frameworks, workflow automation tools, backend integrations, and ... Experience with SQL, Python, and Snowflake highly preferred * Strong verbal and written ...

Socket.dev

Senior Automation Analyst

Greenville, SC · On-site

Evaluate AI platforms, agent frameworks, workflow automation tools, backend integrations, and ... Experience with SQL, Python, and Snowflake highly preferred * Strong verbal and written ...

Accord Technologies Inc.

Sr. Java developer

Rock Hill, SC · On-site

$47.50 - $60.50/hr

... Backend Software Development. Required Skills * Excellent Algorithm and Problem-Solving skills ... Python core concepts and proficiency with its libraries and framework * Familiarity with ...

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Senior Backend Python information

What does a senior backend Python developer do?

A Senior Backend Python Developer designs, builds, and maintains the server-side logic of web applications using Python. They are responsible for creating robust APIs, optimizing databases, ensuring application security, and integrating third-party services. In addition, they often mentor junior developers, contribute to architectural decisions, and collaborate closely with frontend and DevOps teams. Their work ensures that applications are scalable, reliable, and efficient. Senior developers typically have several years of experience and deep knowledge of Python frameworks like Django or Flask.

What are the key skills and qualifications needed to thrive as a senior backend Python developer?

To thrive as a Senior Backend Python Developer, you need expertise in Python programming, strong knowledge of backend frameworks (such as Django or Flask), and experience with database management, often backed by a degree in computer science or equivalent experience. Familiarity with version control systems like Git, containerization tools like Docker, cloud platforms (e.g., AWS), and possibly certifications in cloud or Python technologies are common requirements. Outstanding problem-solving skills, effective communication, and the ability to mentor junior developers help set top performers apart. These competencies ensure the development of robust, scalable, and maintainable backend systems that support business objectives.

What are some common challenges senior backend Python developers face when working on large-scale systems?

Senior Backend Python developers working on large-scale systems often encounter challenges such as ensuring application scalability, maintaining code quality across distributed teams, and optimizing performance for high traffic. Balancing the integration of new features with legacy system constraints can also be demanding. Effective communication and collaboration with frontend teams, DevOps, and product managers are crucial for delivering reliable and maintainable backend solutions.

What is the difference between Senior Backend Python vs Backend Developer?

AspectSenior Backend PythonBackend Developer
Required CredentialsBachelor's in CS or related, 5+ years experience, Python expertiseBachelor's in CS or related, 2-4 years experience, Python knowledge
Work EnvironmentTech companies, startups, enterprise systemsTech firms, startups, software agencies
Employer & Industry UsageUsed across industries requiring scalable backend solutionsCommon in web development and software services
Search & Comparison IntentUnderstanding senior roles, responsibilities, salaryEntry to mid-level backend roles, skill requirements

Senior Backend Python professionals typically have more experience, advanced skills, and leadership responsibilities compared to Backend Developers. They often work on complex systems, mentor junior staff, and have a broader understanding of architecture. Backend Developers focus on building and maintaining backend services with less emphasis on leadership or strategic planning.

Senior Backend Python jobs near you
Infographic showing various Senior Backend Python job openings in South Carolina as of July 2026, with employment types broken down into 92% Full Time, 4% Part Time, and 4% Contract. Highlights an 78% Physical, 4% Hybrid, and 18% Remote job distribution.

Senior Full Stack Developer (Remote Opportunity)

Charleston, SC • On-site

Veterans EZ Info Inc
See more jobs at Veterans EZ Info Incexternal

Other

Medical, Dental, Vision, Retirement, PTO

Posted 13 days ago

Job description

VetsEZ is seeking a Senior Full Stack Developer to support a large federal healthcare technology program. In this role, you will design, develop, test, and maintain modern web applications, APIs, and supporting services across front-end, back-end, and data layers. You will work with architects, product leads, testers, and DevSecOps teams to deliver secure and scalable solutions.

The candidate must reside within the continental US.

Responsibilities:
  • Design, build, enhance, and support full stack applications using modern front-end and back-end technologies.
  • Develop APIs, user interfaces, business logic, and data access components that support platform workflows and integration needs.
  • Collaborate with product, design, and architecture stakeholders to translate requirements into working software solutions.
  • Participate in design reviews, code reviews, testing, troubleshooting, and release support activities.
  • Optimize applications for performance, usability, accessibility, security, and maintainability.
  • Build and maintain integrations with internal services, external systems, and shared platform capabilities.
  • Support defect resolution, production support, and continuous improvement across the application lifecycle.
  • Contribute to technical documentation, coding standards, and reusable development practices.
  • Work within Agile delivery processes and partner with QA and DevSecOps teams to ensure release readiness.
  • Mentor junior developers and contribute to team knowledge sharing.
Requirements:
  • A minimum of 8 years of software development experience, including front-end, back-end, and database work.
  • Experience with modern JavaScript frameworks, HTML, CSS, and responsive web development.
  • Experience with Java, Spring Boot, REST APIs, and enterprise application development.
  • Strong understanding of SQL, relational databases, and application data modeling.
  • Experience with version control, CI/CD pipelines, and modern software development practices.
  • Ability to troubleshoot across UI, service, and data layers.
  • Strong understanding of secure coding, web development best practices, and software quality principles.
  • Experience working in Agile teams and participating in estimation, refinement, and review activities.
  • Bachelor’s degree in Computer Science, Information Technology, Engineering, or a related field, or equivalent experience.
  • Ability to obtain a Government clearance.
Additional Qualifications:
  • Experience with InterSystems IRIS, healthcare integrations, or enterprise interoperability platforms is a plus.
  • Familiarity with React, Redux, Python, PostgreSQL, or containerized deployments is desirable.
  • Experience working with Department of Veterans Affairs or federal healthcare programs is preferred.
  • Relevant certifications in cloud, Agile, or software development are a plus.
  • Experience supporting remote, multi-team delivery environments is preferred
Security Clearance Requirements
  • U.S. Citizenship is required.
  • Must be eligible to obtain and maintain a Government clearance.
Benefits:
  • Medical/Dental/Vision
  • 401k with Matching
  • Corporate Laptop
  • PTO + Federal Holidays
  • Training opportunities
  • Remote opportunity
Note:

Selected candidates will be required to complete fingerprinting at a government facility and undergo a background check as part of the hiring process.

Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, or protected veteran status.

Sorry, we are unable to offer sponsorship at this time.

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