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Senior Ai Software Engineer Jobs in Missouri (NOW HIRING)

AI Software Engineer

California, MO · On-site

$136.80 - $299.30/hr

Deep expertise in software engineering, AI, ASR, or machine learning. * Proficiency in programming languages like C++, Python, and experience with algorithms. * Experience with deep learning, neural ...

AI Software Engineer

Dearborn, MO · On-site

$110 - $150/hr

... Software Engineering or Data Science building scalable production systems. * 1+ years of hands-on experience designing, training, and deploying complex AI/ML systems in production environments.

Senior Software Engineer

O Fallon, MO

$114K - $151K/yr

We are looking for a Senior AI Java Engineer (Hands-on IC) to deliver AI-driven capabilities across ... This role blends Software Engineering (deterministic systems and reliable services) with AI ...

Senior Software Engineer

O Fallon, MO · On-site

$114K - $151K/yr

We are looking for a Senior AI Java Engineer (Hands-on IC) to deliver AI-driven capabilities across ... This role blends Software Engineering (deterministic systems and reliable services) with AI ...

Senior AI Engineer

California, MO · On-site

$187 - $215/hr

Role Overview As a Senior AI Engineer on our Applied AI team, you will design and deploy ... software engineering experience; startup experience strongly preferred * Proven track record ...

Senior AI Platform Engineer (DevOps)

O Fallon, MO · On-site

$121K - $156K/yr

Title and Summary Senior AI Platform Engineer (DevOps) Who is Mastercard? Mastercard powers ... You will collaborate with software engineers, data scientists, infrastructure teams, security ...

Senior AI Engineer

Springfield, MO · On-site

$95K - $130K/yr

Jack Henry's AI Platform team is hiring a Senior AI Engineer to turn promising prototypes into ... We're looking for someone who has shipped scalable, maintainable production software and has run AI ...

Senior AI Engineer

O Fallon, MO · Hybrid

$97K - $134K/yr

Title and Summary Senior AI Engineer Mastercard's Business & Market Insights (B&MI) group empowers organizations to achieve growth and innovation goals by delivering unparalleled data-driven ...

The Sr. AI Developer, Engineering will design, build, and deploy the core application components of ... Stack Engineer or Software Developer building enterprise-grade web applications. * Strong ...

Senior AI Engineer

O Fallon, MO · On-site

$97K - $134K/yr

Title and Summary Senior AI Engineer Mastercard's Business & Market Insights (B&MI) group empowers organizations to achieve growth and innovation goals by delivering unparalleled data-driven ...

Sr. AI Engineer

California, MO · On-site

$127 - $214/hr

As a Sr. AI Engineer II, you'll lead development of production-grade generative AI applications ... Minimum requirements for the role: * 5+ years of industry experience, with a focus on software ...

Senior Software Engineer

California, MO · On-site

$131.25 - $175/hr

## Senior Software EngineerApplylocations: Remote-CA: Remote-WA: Remote-CO: Remote-NY: Remote-OR(PT ... We're also investing heavily in AI-assisted development, and engineers on this team actively use ...

Senior AI/ML Engineer

Saint Louis, MO · On-site

$99K - $136K/yr

Role:-Senior AI/ML Engineer Location: St. Louis, MO (Locals only) Duration:- Long term We are ... Must-Have - 10+ years of software development with strong Python expertise in production ...

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Showing results 1-20

Senior Ai Software Engineer information

What is a senior AI software engineer?

Senior AI Software Engineers are experienced professionals who design, develop, and deploy artificial intelligence (AI) systems and applications. They lead complex projects involving machine learning, deep learning, and data analysis, often mentoring junior engineers and collaborating with data scientists. Their responsibilities include creating scalable AI models, optimizing algorithms, and ensuring that AI solutions meet business objectives. They typically possess advanced knowledge of programming languages such as Python and experience with AI frameworks like TensorFlow or PyTorch. Additionally, they stay updated on the latest AI trends and best practices to drive innovation within their organizations.

What does a senior AI software engineer do?

As a Senior AI Software Engineer, you will frequently work cross-functionally with data scientists and product teams to design, develop, and deploy AI solutions. You’ll translate complex models developed by data scientists into scalable, production-ready code, and ensure the solutions meet performance and reliability standards. Regular communication with product managers and stakeholders is essential to align technical deliverables with business objectives, and you may also mentor junior engineers in best practices for AI system integration.

What are the key skills and qualifications needed to thrive as a senior AI software engineer?

To thrive as a Senior AI Software Engineer, you need deep expertise in machine learning, programming languages such as Python or Java, and a strong background in computer science or a related field, often with an advanced degree. Familiarity with frameworks like TensorFlow or PyTorch, experience deploying models to production, and knowledge of cloud platforms are typically required, along with certifications in AI or data science being advantageous. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These skills ensure the ability to design, build, and scale AI solutions that drive innovation and deliver business value.

What is the difference between Senior Ai Software Engineer vs Data Scientist?

AspectSenior Ai Software EngineerData Scientist
Required CredentialsBachelor's/Master's in CS, AI, or related; experience with AI frameworksBachelor's/Master's in CS, Statistics, or related; experience with data analysis
Work EnvironmentDevelops AI models, software, and algorithms; collaborates with engineering teamsAnalyzes data, builds predictive models, interprets data insights
Employer & Industry UsageTech companies, AI startups, R&D departmentsTech firms, finance, healthcare, research institutions

While both roles require strong technical skills and experience with AI tools, Senior Ai Software Engineers focus on developing and deploying AI software solutions, whereas Data Scientists primarily analyze data to generate insights and build predictive models. The roles often overlap but differ in their core responsibilities and focus areas.

What cities in Missouri are hiring for Senior Ai Software Engineer jobs?

Cities in Missouri with the most Senior Ai Software Engineer job openings:

Infographic showing various Senior Ai Software Engineer job openings in Missouri as of August 2026, with employment types broken down into 90% Full Time, 7% Part Time, and 3% Contract. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution.

Senior AI Software Engineer-TS/SCI clearances (CI poly preferred)

Saint Louis, MO • On-site

$119K - $157K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 16 days ago


Job description

Overview

Join a team where innovation meets mission. Our AI, cloud, cyber, and modernization solutions save agencies thousands of hours, safeguard national security, and strengthen health and humanitarian missions worldwide. With 1,700+ team members, 1,500+ AI/data experts, and 100+ prime contracts, we deliver at scale and with purpose.

We’ve been recognized as a Top Workplace by the Washington Post for six straight years and named to the Inc. 5000 Fastest Growing Private Companies 13 of the past 14 years. Credence is a welcoming home for those looking to grow and contribute to positive change. We encourage all employees to expand beyond their boundaries, dive into important world-changing Federal challenges.

Position Summary

Credence has an immediate need for a Senior AI Software Engineer to join our growing AI and Automation practice. In this role, you will serve as a senior technical contributor responsible for designing, developing, and deploying advanced AI-driven solutions, including generative AI, LLM-powered applications, and agentic AI systems. You will collaborate with cross-functional engineering, data, cloud, and stakeholder teams to deliver scalable, secure, and mission-focused AI capabilities for federal clients, while helping guide technical direction, strengthen engineering practices, and mentor other engineers.

Responsibilities include, but are not limited to the duties listed below

  • Generative AI & LLM Solution Delivery
    Lead the design, development, prototyping, and refinement of AI-powered capabilities using generative AI, large language models, retrieval patterns, prompt/context engineering, and secure API integrations.
  • Agentic AI System Development
    Own end-to-end agentic AI development lifecycles, including model selection, agent design, tool/function calling, orchestration, response synthesis, evaluation, and deployment of reliable AI agents.
  • Senior Software Engineering Leadership
    Apply strong software engineering principles to design maintainable, testable, and scalable systems; conduct code reviews, establish technical patterns, and leverage AI-assisted development tools responsibly to accelerate delivery.
  • Cross-Functional Technical Collaboration
    Partner with data engineers, software engineers, data scientists, cloud engineers, and mission stakeholders to translate business and mission needs into operational AI and automation solutions.
  • Cloud Enablement & DevSecOps Integration
    Design and automate deployment workflows using Infrastructure as Code (IaC), CI/CD pipelines, containers, and cloud-native services to support secure, repeatable, and scalable AI delivery.
  • Production Monitoring & Optimization 
    Monitor AI systems post-deployment, perform performance tuning, and apply best practices for reliability and scalability.
  • Technical Rigor & Documentation 
    Write clean, well-documented code following industry and federal guidelines; support reproducible development.
  • Technical Mentorship & Continuous Improvement
    Stay current on emerging AI/ML trends, agentic frameworks, model capabilities, and engineering practices while mentoring team members and contributing to reusable standards, documentation, and technical design reviews.

Requirements

What You Bring

  • TS/SCI clearances Required (CI poly preferred).
  • Bachelor’s or Master’s in Computer Science, AI/ML, or a related field.
  • 7+ years of hands-on software engineering experience, including significant experience delivering AI/ML, generative AI, or LLM-powered solutions in production or production-like environments.
  • Experience building generative AI applications, working with LLMs, implementing tool/function calling, and applying model evaluation, prompt/context engineering, or retrieval-augmented generation approaches.
  • Experience designing or implementing agentic AI solutions using frameworks or platforms such as Agent2Agent Protocol, Bedrock Agents, Mastra, CrewAI, Strands, AgentCore, LangChain, or LangGraph.
  • Strong understanding of leading AI APIs and model platforms such as OpenAI, Anthropic, Gemini, Amazon Bedrock, and Google Vertex AI.
  • Proficiency in TypeScript and familiarity with key libraries and frameworks such as Nx, Next.js, Mastra, Vercel AI SDK, Playwright, Jest, and Vite.
  • Python proficiency and familiarity with libraries and frameworks (uv, Pydantic, FastAPI, CrewAI, LangChain, LangGraph, Unstructured).
  • Demonstrated curiosity and practical experimentation with emerging AI technologies, with a strong focus on responsible innovation and measurable mission impact.
  • Familiarity with CI/CD pipelines (GitLab CI)
  • Experience with VS Code and AI extensions such as Cline and Claude Code.
  • Strong communication skills and client-oriented mindset.

Preferred

  • Curious and experimental about the latest innovations in AI with an orientation toward the relentless pursuit of delivering mission impact.
  • Exposure to adjacent skillsets such as data engineering, data science, UI/UX, cloud engineering, and platform engineering to understand the entire software ecosystem.
  • Experience with IaC tools such as Terraform, Open Tofu, AWS CDK, or CloudFormation to deploy cloud native applications.
  • Knowledge of federal cybersecurity, RMF, FedRAMP, or regulatory frameworks.

Why This Role Matters

  • Real-World Impact — Your work will support defense and health agencies where AI solutions directly contribute to national security and public well-being.
  • Growth-Oriented Technical Leadership — Work with technical leaders, shape agentic AI delivery practices, and mentor team members while continuing to deepen your own expertise in advanced AI engineering.
  • Culture of Empowerment — You’ll be part of a team that values innovation, trust, collaboration, and mission success.

 Salary Range: $155,000 - $200,000 annually. Actual compensation will be determined based on the selected candidate's experience, education, certifications, skills, and overall qualifications.

Benefits

  • Health Care Plan (Medical, Dental & Vision)
  • Retirement Plan (401k, IRA)
  • Life Insurance (Basic, Voluntary & AD&D)
  • Paid Time Off (Vacation, Sick & Public Holidays)
  • Family Leave (Maternity, Paternity)
  • Short Term & Long Term Disability
  • Training & Development
  • Wellness Resources