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Scorpion Therapeutics

Senior Scientist I, DMPK

Madison, WI · On-site

$115K - $140K/yr

Maintain current knowledge of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics. Requirements: * PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical ...

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How much do rnai phd jobs pay per hour?

As of Sep 12, 2026, the average hourly pay for rnai phd in the United States is $29.44, according to ZipRecruiter salary data. Most workers in this role earn between $25.48 and $32.93 per hour, depending on experience, location, and employer.

What is an RNAi PhD?

RNAi PhDs are individuals who have earned a doctoral degree (PhD) specializing in RNA interference (RNAi), a biological process where RNA molecules inhibit gene expression or translation. Their research often focuses on understanding gene regulation, developing RNAi-based therapies, or using RNAi technologies in biotechnology and medicine. These experts typically work in academia, pharmaceutical companies, or biotech firms, contributing to advancements in gene silencing and therapeutic development. The field requires a strong background in molecular biology, genetics, and laboratory research techniques.

What are some typical collaborative projects that an RNAi PhD is involved in within a research institution or industry setting?

As an RNAi PhD researcher, you will often collaborate with multidisciplinary teams, including molecular biologists, bioinformaticians, and clinical researchers. Projects may involve designing and executing gene-silencing experiments, validating target genes, or developing RNAi-based therapeutics. Collaboration is essential for integrating RNAi findings with broader research goals, such as drug discovery or understanding disease mechanisms. Regular meetings, data sharing, and joint problem-solving are common, making teamwork and communication vital skills in this role.

What are the key skills and qualifications needed to thrive as an RNAi PhD, and why are they important?

To thrive as an RNAi PhD, you need advanced knowledge in molecular biology, gene silencing technologies, and experimental design, typically supported by a PhD in a related life science field. Familiarity with laboratory techniques such as RNA interference assays, CRISPR, qPCR, and bioinformatics tools is essential. Strong analytical thinking, attention to detail, and clear scientific communication are critical soft skills for excelling in research and collaborative environments. These skills ensure rigorous, innovative research and effective dissemination of findings in the fast-evolving field of RNAi.

What is the difference between Rnai Phd vs Molecular Biologist?

AspectRnai PhdMolecular Biologist
Required CredentialsPhD in Molecular Biology, Genetics, or related field; expertise in RNA interference techniquesTypically a Bachelor's or Master's degree; some roles require PhD
Work EnvironmentResearch labs, biotech companies, academic institutionsResearch labs, healthcare, biotech, academia
Industry UsagePrimarily in research and development of gene silencing therapiesBroadly in genetics, cell biology, and biomedical research

While both roles involve molecular biology expertise, Rnai Phd positions focus specifically on RNA interference techniques and often require a PhD with specialized training. Molecular Biologists may have a broader scope, working across various areas of genetics and cell biology, with some roles requiring only a Bachelor's or Master's degree. Rnai Phd roles tend to be more specialized in gene silencing research, whereas Molecular Biologists work in diverse research settings.

What are popular job titles related to Rnai Phd jobs?

For Rnai Phd jobs, the most frequently searched job titles are:

Infographic showing various Rnai Phd job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 85% Full Time, 12% Part Time, and 2% Contract. Highlights an 78% Physical, 4% Hybrid, and 18% Remote job distribution, with an average salary of $61,245 per year, or $29.4 per hour.

Senior Manager, Process Development

Madison, WI • On-site

Arrowhead Pharmaceuticals
Pharmaceutical and Medicine Manufacturing • 201 - 500 employees
Learn more about Arrowhead Pharmaceuticalsexternal

$140K - $165K/yr

Full-time

Re-posted 6 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

We are seeking a Senior Manager, Process Development on our Late Phase Development team to lead the strategy and execution of raw material manufacturing, regulatory classification, and supply for our oligonucleotide programs. This individual will own the regulatory starting material (RSM) strategy, provide technical oversight of small molecule synthesis, and manage outsourced manufacturing relationships with contract manufacturing organizations (CMOs) and raw material suppliers. The ideal candidate combines strong chemistry fundamentals with regulatory acumen and proven vendor/CRO/CMO management experience.

This role is full-time onsite, 5 days a week in Verona, WI. 

Responsibilities

  • Define and defend regulatory starting material designations for synthetic routes in collaboration with Regulatory Affairs, in alignment with ICH Q11
  • Author and review RSM justification sections for regulatory filings (IND/IMPD, NDA, MAA, etc.)
  • Evaluate synthetic route changes for their impact on RSM designation and regulatory strategy
  • Provide technical review and oversight of synthetic routes, process chemistry, and impurity control strategies for small molecules
  • Assess raw material and starting material specifications to ensure fitness for intended use and consistency with quality target product profiles
  • Support technology transfer of synthetic processes from development to kilo-scale manufacturing
  • Manage day-to-day relationships with CMOs and raw material/starting material suppliers, serving as the primary technical point of contact
  • Lead supplier selection onboarding for raw materials and starting materials
  • Manage PD scientists and assists in the prioritization and management of work flow
  • Provides leadership, technical guidance, and mentoring and development of PD scientists
  • Prepare technical reports, presentations, SOPs, Work Instructions, and procedures
  • Approve technical documentation and workflows
  • Work with cross-functional teams (Process Development, QA, Regulatory, Discovery, AD, Manufacturing, PM, and others as needed) to develop and meet project goals and deliverables
  • Work with third party vendors and CDMOs to meet project deliverables.
  • Monitor and report progress of PD project deliverables within agreed project timelines

Requirements

  • Ph.D. in Organic Chemistry or a related field with 5+ years, M.S. with 10+ years, or B.S. with 12+ years of relevant industry experience in chemistry.
  • Demonstrated expertise with organic chemistry theory and practice.
  • Demonstrated experience with pharmaceutical drug substance development and processes

Preferred

  • PhD or Master's Degree 
  • Experience with regulatory interactions (meetings, information requests, filings) related to CMC/starting materials
  • Familiarity with GMP requirements for raw material and API manufacturing
  • Prior people management or team leadership experience
Wisconsin pay range
$140,000—$165,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

Candidates must have current, valid authorization to work in the country where this role is located.

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