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Arrowhead Pharmaceuticals

Medical Science Liaison

Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is ... PhD, PharmD, MD, or DO required. * 2+ years of experience as a Medical Science Liaison (MSL)

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How much do rnai phd jobs pay per hour?

As of Sep 9, 2026, the average hourly pay for rnai phd in the United States is $29.44, according to ZipRecruiter salary data. Most workers in this role earn between $25.48 and $32.93 per hour, depending on experience, location, and employer.

What is an RNAi PhD?

RNAi PhDs are individuals who have earned a doctoral degree (PhD) specializing in RNA interference (RNAi), a biological process where RNA molecules inhibit gene expression or translation. Their research often focuses on understanding gene regulation, developing RNAi-based therapies, or using RNAi technologies in biotechnology and medicine. These experts typically work in academia, pharmaceutical companies, or biotech firms, contributing to advancements in gene silencing and therapeutic development. The field requires a strong background in molecular biology, genetics, and laboratory research techniques.

What are some typical collaborative projects that an RNAi PhD is involved in within a research institution or industry setting?

As an RNAi PhD researcher, you will often collaborate with multidisciplinary teams, including molecular biologists, bioinformaticians, and clinical researchers. Projects may involve designing and executing gene-silencing experiments, validating target genes, or developing RNAi-based therapeutics. Collaboration is essential for integrating RNAi findings with broader research goals, such as drug discovery or understanding disease mechanisms. Regular meetings, data sharing, and joint problem-solving are common, making teamwork and communication vital skills in this role.

What are the key skills and qualifications needed to thrive as an RNAi PhD, and why are they important?

To thrive as an RNAi PhD, you need advanced knowledge in molecular biology, gene silencing technologies, and experimental design, typically supported by a PhD in a related life science field. Familiarity with laboratory techniques such as RNA interference assays, CRISPR, qPCR, and bioinformatics tools is essential. Strong analytical thinking, attention to detail, and clear scientific communication are critical soft skills for excelling in research and collaborative environments. These skills ensure rigorous, innovative research and effective dissemination of findings in the fast-evolving field of RNAi.

What is the difference between Rnai Phd vs Molecular Biologist?

AspectRnai PhdMolecular Biologist
Required CredentialsPhD in Molecular Biology, Genetics, or related field; expertise in RNA interference techniquesTypically a Bachelor's or Master's degree; some roles require PhD
Work EnvironmentResearch labs, biotech companies, academic institutionsResearch labs, healthcare, biotech, academia
Industry UsagePrimarily in research and development of gene silencing therapiesBroadly in genetics, cell biology, and biomedical research

While both roles involve molecular biology expertise, Rnai Phd positions focus specifically on RNA interference techniques and often require a PhD with specialized training. Molecular Biologists may have a broader scope, working across various areas of genetics and cell biology, with some roles requiring only a Bachelor's or Master's degree. Rnai Phd roles tend to be more specialized in gene silencing research, whereas Molecular Biologists work in diverse research settings.

What are popular job titles related to Rnai Phd jobs?

For Rnai Phd jobs, the most frequently searched job titles are:

Infographic showing various Rnai Phd job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 85% Full Time, 11% Part Time, and 3% Contract. Highlights an 79% Physical, 4% Hybrid, and 17% Remote job distribution, with an average salary of $61,245 per year, or $29.4 per hour.

Director, Pharmacometrics & Clinical Pharmacology

San Diego, CA

Arrowhead Pharmaceuticals
Pharmaceutical and Medicine Manufacturing • 201 - 500 employees
Learn more about Arrowhead Pharmaceuticalsexternal

Full-time

Re-posted 26 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Arrowhead Pharmaceuticals is seeking a Director of Pharmacometrics and Clinical Pharmacology to provide strategic and scientific leadership across the company's clinical development programs. This senior-level role is responsible for advancing pharmacometric and clinical pharmacology strategies to support the global development and regulatory submission of Arrowhead's leading siRNA therapeutics.

The Director will play a critical role in clinical trial design, data analysis, regulatory documentation, and cross-functional decision-making, ensuring that dosing strategies and clinical pharmacology plans are scientifically rigorous and aligned with regulatory expectations.

Responsibilities

  • Serve as the pharmacometrics and clinical pharmacology lead across multiple development programs within Arrowhead's RNAi therapeutic portfolio.
  • Lead model-informed drug development strategies, including population PK/PD analyses, exposure-response analyses, translational modeling, dose optimization, and quantitative interpretation of clinical and translational data.
  • Develop and support clinical pharmacology strategies for first-in-human studies, dose escalation and optimization, proof-of-concept studies, drug-drug interaction assessments, food effect studies, and special population evaluations.
  • Provide scientific leadership and oversight for PK/PD analyses and modeling activities conducted internally and through external CRO partners.
  • Contribute to global regulatory submissions and health authority interactions, including INDs, CTAs, NDA/BLA submissions, briefing documents, and responses to agency questions.
  • Author and review clinical pharmacology content for Investigational Brochures (IBs), clinical protocols, Clinical Study Reports (CSRs), and regulatory submission documents.
  • Collaborate closely with Clinical Development, Translational Sciences, Regulatory Affairs, Biometrics, Biomarkers, Medical Affairs, and Program Leadership teams to support program strategy and execution.
  • Present quantitative analyses, development strategies, and recommendations to project teams and senior leadership.
  • Maintain current knowledge of evolving scientific methodologies, regulatory guidance, and industry trends related to pharmacometrics, clinical pharmacology, and RNAi therapeutics.

Requirements

  • PhD or equivalent advanced degree in Pharmacokinetics, Pharmacology, Pharmaceutical Sciences, Biomedical Engineering, Applied Mathematics, or related quantitative discipline.
  • 12+ years in pharmacometrics and/or clinical pharmacology, including experience supporting late-stage development programs and global regulatory submissions.
  • Deep expertise in population PK/PD modeling and simulation with strong proficiency in industry-standard software such as NONMEM.
  • Strong understanding of exposure-response analysis, translational modeling, dose optimization, and model-informed drug development principles.
  • Experience supporting regulatory interactions with FDA, EMA, and other global health authorities.
  • Knowledge of PBPK, QSP, mechanistic modeling, or systems pharmacology approaches is highly desirable.
  • Prior experience with oligonucleotide, RNAi, rare disease, liver-targeted therapeutics, or other complex biologic modalities is preferred.
  • Demonstrated ability to independently lead complex scientific initiatives and influence cross-functional teams in a matrixed environment.
  • Excellent communication and presentation skills, with the ability to clearly communicate complex quantitative concepts to scientific and non-scientific audiences.

Preferred

  • Familiarity with PBPK/PD or quantitative systems pharmacology (QSP) modeling
Wisconsin pay range
$200,000—$230,000 USD
California pay range
$230,000—$255,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

Candidates must have current, valid authorization to work in the country where this role is located.

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