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Research Associate Downstream Process Development Jobs in Connecticut

Element Solutions Inc

R&D Chemist II

Shelton, CT · Hybrid

Wafer Level Packaging - Revolutionizing wafer fabrication processes for enhanced efficiency and ... The candidate will work closely with R&D scientists, application engineers, product management, and ...

Element Solutions Inc

R&D Chemist II

Shelton, CT · Hybrid

Wafer Level Packaging - Revolutionizing wafer fabrication processes for enhanced efficiency and ... The candidate will work closely with R&D scientists, application engineers, product management, and ...

Element Solutions

R&D Chemist II

Shelton, CT · On-site

Wafer Level Packaging - Revolutionizing wafer fabrication processes for enhanced efficiency and ... The candidate will work closely with R&D scientists, application engineers, product management, and ...

Oetiker

R&D Project Manager

Wallingford, CT · On-site

This role manages R&D development projects of mechanical and electro-mechanical hand tool in the ... Project management from idea to series production, incl. contribution to product and process ...

IDEX

Director of Process Engineering

Farmington, CT · On-site

$158K - $237K/yr

New Product Introduction (NPI) & Scale‑Up - partner with R&D and cross‑functional teams to ... Process Capability & Technology Development - advance core manufacturing technologies in advanced ...

Elm City Tools

R&D Project Manager

Wallingford, CT · On-site

This role manages R&D development projects of mechanical and electro-mechanical hand tool in the ... Project management from idea to series production, incl. contribution to product and process ...

Elm City Tools

R&D Project Manager

Wallingford, CT · On-site

This role manages R&D development projects of mechanical and electro-mechanical hand tool in the ... Project management from idea to series production, incl. contribution to product and process ...

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All JobsResearch Associate Downstream Process Development JobsResearch Associate Downstream Process Development Jobs in Connecticut

Research Associate Downstream Process Development information

What is a research associate downstream process development?

A Research Associate in Downstream Process Development works within biotechnology or pharmaceutical companies to optimize and scale up the purification and recovery of biological products, such as proteins or antibodies, after initial production. They focus on processes like filtration, chromatography, and centrifugation to ensure product quality and yield. These professionals design experiments, analyze data, and support the transfer of processes from laboratory scale to manufacturing. Their work is crucial for developing efficient, reproducible, and regulatory-compliant methods for producing biopharmaceuticals.

What are the key skills and qualifications needed to thrive as a research associate in downstream process development?

To thrive as a Research Associate in Downstream Process Development, you need a solid background in biochemistry, molecular biology, or chemical engineering, often demonstrated by a bachelor's or master's degree in a related field. Familiarity with chromatography systems (such as AKTA), filtration technologies, and Good Manufacturing Practice (GMP) standards, along with data analysis software, is typically required. Strong problem-solving skills, attention to detail, and effective teamwork and communication abilities help individuals excel in this role. These competencies are crucial for ensuring efficient, scalable purification processes and maintaining product quality in biopharmaceutical development.

What are the typical challenges faced by a research associate in downstream process development, and how can they be addressed?

A Research Associate in Downstream Process Development often encounters challenges such as optimizing purification processes for new biologics, troubleshooting equipment issues, and ensuring scalability from laboratory to production scale. Effective communication with cross-functional teams, such as upstream scientists and analytical specialists, is essential to resolve issues quickly. Staying current with new purification technologies and maintaining meticulous documentation can also help address these challenges and support successful process development.

What is the difference between Research Associate Downstream Process Development vs Research Associate Upstream Process Development?

AspectResearch Associate Downstream Process DevelopmentResearch Associate Upstream Process Development
Primary FocusPurification, filtration, chromatography of bioproductsCell culture, media optimization, bioreactor operation
Skills & CertificationsProtein purification, chromatography techniques, GMP complianceCell culture, aseptic techniques, bioreactor handling
Work EnvironmentLaboratory, manufacturing, quality controlLaboratory, bioprocessing facilities
Industry UsageBiopharmaceutical manufacturing, biotech researchBiopharmaceutical development, biotech research

While both roles support bioprocess development, Research Associate Downstream Process Development focuses on purification and filtration of bioproducts, whereas Research Associate Upstream Process Development emphasizes cell culture and bioreactor processes. Understanding these differences helps candidates align their skills with the appropriate role in biopharmaceutical production.

Research Associate Downstream Process Development jobs near you
Infographic showing various Research Associate Downstream Process Development job openings in Connecticut as of September 2026, with employment types broken down into 67% Full Time, and 33% Contract. Highlights an 100% In-person job distribution.

Sr. Scientist/Engineer, Process Development

Danbury, CT • On-site

MannKind Corporation
Pharmaceutical and Medicine Manufacturing • 201 - 500 employees
Learn more about MannKind Corporationexternal

$106K - $137K/yr

Other

Re-posted 25 days ago

Job description

MannKind Corporation is a biopharmaceutical company focused on transforming chronic disease care through patient-centric solutions, developing and commercializing inhaled therapeutics and drug-device technologies for unmet needs across endocrine, cardiorenal, and orphan lung diseases.

At MannKind, our employees are a core asset, and we foster a collaborative culture where each team member contributes to improving health outcomes and changing lives.

Position Summary

Provide advanced scientific and technical leadership in the development, optimization, scale-up, and lifecycle management of pharmaceutical manufacturing processes across the product lifecycle. Operate as a senior individual contributor within the process development department, applying independence, technical judgment, and subject-matter expertise. Support clinical and commercial manufacturing by ensuring processes are scalable, robust, and compliant, while contributing to cross-functional technical decision-making and continuous improvement across MannKind’s product portfolio.

Essential duties and responsibilities
  • Lead the design, development, and optimization of pharmaceutical manufacturing processes from late-stage development through commercialization.
  • Apply sound scientific principles, experimental design, and data-driven methodologies to establish process understanding and improve process robustness and capability. Independently plan, execute, analyze, and document complex experimental studies in support of process development and process characterization.
  • Serve as a subject matter expert for specific unit operations, process technologies, or platform processes, providing technical guidance across functions.
  • Support process scale-up, technology transfer, and process validation activities by generating technical documentation and providing hands-on consultative support.
  • Collaborate cross-functionally with manufacturing, engineering, quality, analytical development, regulatory, and external partners to ensure successful process implementation.
  • Manage equipment maintenance, including calibrations/qualifications.
  • Support investigations related to process deviations, manufacturing issues, and continuous improvement initiatives.
  • Author and review development reports, protocols, technical summaries, and regulatory documentation in compliance with cGMP and regulatory expectations.
  • Contribute to process lifecycle management activities, including continuous improvement, change management, and technical risk assessments.
  • Provide technical mentorship and informal coaching to junior scientists and associates to elevate team technical capability.
  • Observe all Company, Health, Safety and Environmental guidelines.
  • Duties and responsibilities are not limited to the work listed above and may include other assignments as necessary.
Minimum qualifications
  • BS/BA with 6-8 years, MS with 4–6 years or PhD, or relevant experience in Chemistry, Chemical Engineering or a related field, with experience in pharmaceutical process development and/or manufacturing support.
  • Experience in the development and scale-up of drug manufacturing processes.
  • Experience preferred in the manufacture, packaging, and kitting of clinical phase drug products.
  • Experience with orally inhaled dosage forms is strongly preferred.
  • Experience with the following unit operations preferred: spray drying, wet nano-milling, tangential flow filtration, micro fluidization.
  • Experience managing second-party resources, including clinical packaging vendors and contract development and manufacturing organizations.
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