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PathoMap

Functional Medical Provider

Baltimore, MD · Remote

Greater Baltimore, MD area (or Remote with license in Maryland) Compensation: Competitive salary ... structural metabolic management). By addressing chronic disease pathology at the cellular and ...

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How much do remote structural biology jobs pay per year?

As of Jun 8, 2026, the average yearly pay for remote structural biology in the United States is $99,400.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,000.00 and $113,000.00 per year, depending on experience, location, and employer.

What is remote structural biology?

Remote structural biology refers to the study and analysis of biological macromolecules' structures (like proteins and nucleic acids) using computational tools and online platforms, rather than working in a physical laboratory. Scientists in this field often use software for molecular modeling, data analysis, and remote access to experimental facilities such as synchrotrons. This approach allows researchers to collaborate globally, access specialized equipment, and analyze structural data from anywhere with an internet connection.

What are the typical challenges faced by structural biologists working in a fully remote environment?

Remote structural biologists often face challenges related to accessing specialized equipment, such as cryo-EM or X-ray crystallography facilities, which are typically available only in well-equipped labs. Collaboration and data sharing with team members can also be more complex, requiring robust digital workflows and frequent virtual meetings to ensure alignment. However, many organizations address these challenges by providing remote access to computational resources, cloud-based data storage, and encouraging strong communication through project management tools. Building relationships with colleagues and maintaining up-to-date knowledge of advancements may require greater initiative in a remote setting, but virtual conferences and online seminars can help bridge the gap.

What are the key skills and qualifications needed to thrive as a Remote Structural Biologist, and why are they important?

To thrive as a Remote Structural Biologist, you need a strong background in biochemistry, molecular biology, and structural analysis, often supported by a relevant advanced degree (PhD or MSc). Proficiency with structural biology tools such as X-ray crystallography, cryo-EM, NMR spectroscopy, and computational modeling software (e.g., PyMOL, Chimera, or Rosetta) is essential. Exceptional analytical thinking, attention to detail, and clear virtual communication skills set top performers apart in remote environments. These skills are crucial for accurately interpreting molecular structures, collaborating effectively across distances, and advancing research in structural biology.
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What cities are hiring for Remote Structural Biology jobs? Cities with the most Remote Structural Biology job openings:
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Remote Structural Biology jobs near you
Infographic showing various Remote Structural Biology job openings in the United States as of May 2026, with employment types broken down into 88% Full Time, and 12% Part Time. Highlights an 77% Physical, 2% Hybrid, and 21% Remote job distribution, with an average salary of $99,400 per year, or $47.8 per hour.

Associate Director, Analytical Sciences and Attribute Characterization

Spyre Therapeutics

Remote

$175K - $190K/yr

Full-time

Medical, Retirement, PTO

Posted 12 days ago

Job description

Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.
Role Summary:
The Associate Director, Analytical Sciences and Attribute Characterization, oversees structural and functional characterization and comparability studies across Spyre's clinical and late-stage mAb and mAb-mAb combination programs. This role is a key leader within the Analytical Development and Quality Control (ADQC) organization and reports directly to the Vice President.
The position provides both strategic and operational leadership for analytical characterization and comparability, in close collaboration with internal process, analytical, and regulatory teams, as well as global CDMO partners. The Associate Director defines phase-appropriate characterization and comparability strategies that support formulation, process, and analytical development, quality control, and regulatory submissions, aligned with regulatory expectations and industry best practices. This role drives proactive planning to ensure efficient advancement of drug candidates through clinical development stages.
Key Responsibilities:
  • Provide strategic and technical leadership for multidimensional biologics characterization to support product understanding and comparability in a phase-appropriate manner, enabling regulatory submissions for clinical development through BLA & MAA, primarily executed through global CDMO partners.
  • Serve as subject matter expert (SME) in mAb and mAb-mAb combination product molecular characterization and comparability, applying a fit-for-purpose suite of biochemical, biophysical, physicochemical, and functional assays (e.g., advanced mass spectrometry, capillary and chromatographic methods, deterministic biophysical and particle analyses, Fc function assays including SPR, cell-based assays, and surfactant analysis).
  • Contribute to analytical control strategies and regulatory content development, ensuring scientific rigor, comprehensive product understanding, and assessment of process impacts on product quality attributes across DS, DP, placebo, and device manufacturing.
  • Lead comparability and characterization activities at CDMOs, including review and approval of protocols, reports, and data packages, and verification of analytical results to support regulatory submissions.
  • Ensure analytical activities, both internal and external, meet scientific, regulatory (FDA, EMA, ICH), and industry standards.
  • Develop characterization strategies in collaboration with analytical SMEs, ensuring alignment and complementarity with QC methods for release, stability, and in-process controls.
  • Partner with process (DS, DP, device) and regulatory teams to establish product-appropriate characterization and comparability plans.
  • Support ADQC activities, including method development, investigations, and review of QC release and stability data, as needed.
  • Establish best practices and protocols for structure-function relationships, post-translational modification (PTM) analysis, biophysical characterization, and critical quality attribute (CQA) assessment.
  • Other duties as assigned.

Ideal Candidate:
  • Advanced degree in Mass spectrometry, Biophysical chemistry, Analytical Chemistry, Pharmaceutical Sciences, Biochemistry or a related discipline, with 8+ years of biopharma industry experience in biologics analytical, formulation or process development.
  • Demonstrated experience and success supporting regulatory submissions (IND, CTA, BLA), with strong expertise in phase-appropriate characterization and comparability studies and associated analytical methods.
  • Proven leadership and effective communication skills, with the ability to manage biologics program deliverables in a fast-paced environment; experience with mAb combination products is preferred, and device testing is an advantage.
  • Experience leveraging artificial intelligence (AI) and machine learning (ML) to enhance analytical efficiency, automate attribute trending, and support knowledge generation and decision-making.

What We Offer:
  • Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
  • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
  • Unlimited PTO
  • Two, one-week company-wide shutdowns each
  • Commitment to provide professional development opportunities.
  • Remote working environment with frequent in-person meetings to address complex problems and build relationships.

The expected salary range offer for this role is $175,000 to $190,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.
As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.
Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain "@spyre.com." We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.
Please also be aware that all job postings will be listed on our website at spyre.com/careers/.

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