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Remote Software Engineer 500K Jobs in Oklahoma (NOW HIRING)

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

Engineer II (ILI Data Analysis)

Tulsa, OK ยท On-site +1

$104K - $125K/yr

The schedule is Hybrid, working from the Tulsa office Monday-Thursday and working remote on Friday ... Experience in use and function of office equipment such as computers and applicable software ...

Remote opportunity within Oklahom . Occasional onsite meetings may be required. Travel expenses ... Knowledge of Agile software development methodologies and secure coding practices. * Experience ...

SAP Integration Engineer

Tulsa, OK ยท Remote

$90 - $120/hr

Term: 6-month Contract to hire Location: 100% remote with lite travel into Tulsa, OK Pay: $90-$120 ... M-F 9-5 We are seeking an experienced SAP Integration Engineer with deep expertise in Teamcenter ...

Showing results 21-40

Remote Software Engineer 500K information

What is a remote software engineer 500k?

A Remote Software Engineer earning $500K is a highly skilled software professional who works from a location outside of a traditional office and receives a total annual compensation of around $500,000. This compensation usually includes base salary, bonuses, stock options, and other benefits. Such high salaries are typically found at leading tech companies, particularly in senior, staff, or principal engineering roles, or at fast-growing startups with substantial equity packages. These engineers are expected to have deep technical expertise, years of experience, and the ability to deliver significant impact to their organizations.

What are the key skills and qualifications needed to thrive as a remote software engineer?

To thrive as a Remote Software Engineer, you need advanced programming expertise, a strong grasp of software development principles, and typically a degree in computer science or a related field. Familiarity with distributed version control systems like Git, cloud platforms such as AWS or Azure, and CI/CD pipelines is essential, along with relevant certifications. Outstanding communication, self-motivation, and problem-solving abilities are crucial for effective remote collaboration and autonomy. These skills and qualities ensure high productivity, code quality, and seamless teamwork in a distributed work environment.

How do remote software engineers at high compensation levels typically collaborate with distributed teams to ensure project success?

Remote Software Engineers working at top compensation tiers often collaborate with globally distributed teams using a mix of synchronous and asynchronous communication tools, such as Slack, Zoom, and project management platforms like Jira. They are expected to proactively communicate progress, share updates, and participate in code reviews to maintain alignment across time zones. Building trust and maintaining transparency are crucial, as is the ability to document work thoroughly to ensure everyone stays on the same page. High compensation roles may also require engineers to mentor peers and influence technical direction, making strong collaboration skills essential for both individual and team success.

What is the difference between Remote Software Engineer 500K vs Remote Software Engineer 200K?

AspectRemote Software Engineer 500KRemote Software Engineer 200K
Salary RangeUp to 500K annuallyUp to 200K annually
Experience LevelSenior to expert levelMid to senior level
Work EnvironmentRemote, often with global companiesRemote, with startups or established firms
Required CredentialsAdvanced degrees, extensive experience, specialized skillsRelevant experience, possibly some certifications

The main difference between Remote Software Engineer 500K and Remote Software Engineer 200K lies in compensation, experience, and skill level. The 500K role typically requires extensive expertise and offers higher compensation, often in senior or specialized positions. The 200K role is suitable for mid-level engineers with solid experience. Both roles are remote and industry-standard, but the 500K position is more competitive and demanding.

What are the most commonly searched types of Software Engineer 500K jobs in Oklahoma?

The most popular types of Software Engineer 500K jobs in Oklahoma are:

Infographic showing various Remote Software Engineer 500K job openings in Oklahoma as of August 2026, with employment types broken down into 88% Full Time, 8% Part Time, and 4% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution.

Bioinformatics Software Engineer

micro1 AI

Edmond, OK โ€ข Remote

$80 - $110/hr

Part-time

Posted 18 days ago


Job description

Role Title: Computational Biology & Cheminformatics Expert


Role Type: Contractor


Location: Remote


micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customerโ€™s computational drug discovery project. In this role, you'll apply your expertise to help train next-generation AI systems. Your work will shape how models learn, reason, and perform through high-quality, real-world input. No prior experience in AI is required โ€” your domain knowledge is what matters.


Scope of Work

  1. Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods.
  2. Curate, annotate, and validate chemical and biological datasets (e.g., ChEMBL, PubChem, DrugBank) to support AI-driven discovery platforms.
  3. Evaluate compound-target interactions, ADMET properties, and lead optimization strategies by integrating chemical, biological, and clinical data sources.
  4. Provide expert insights on structure-activity and structure-property relationships (SAR/SPR), medicinal chemistry approaches, and experimental design considerations.
  5. Build and implement code-based benchmark tasks (e.g., terminal/CLI-based environments) that reflect realistic computational drug discovery scenarios.
  6. Develop reproducible environments (e.g., using Docker) and automated testing pipelines to ensure task correctness and solvability.
  7. Assess and review AI-generated outputs for scientific rigor, accuracy, and practical relevance, delivering detailed written feedback and recommendations.


Preferred Qualifications

  1. Advanced expertise in Computational Biology, Cheminformatics, Medicinal Chemistry, Biochemistry, or related fields; advanced degree (PhD, MSc, PharmD) highly valued but not strictly required.
  2. Strong coding proficiency in Python (beyond analysis scripts), with hands-on experience building tools, pipelines, or testable code; familiarity with Git, GitHub, and Docker.
  3. Extensive experience with cheminformatics toolkits and platforms such as RDKit, KNIME, Schrรถdinger, OpenEye, or MOE.
  4. Proven track record in small-molecule drug discovery, SAR/QSAR evaluation, ADMET prediction, or virtual screening workflows.
  5. Comfort working with public chemical and bioactivity databases and integrating diverse datasets for scientific analysis.
  6. Demonstrated ability to clearly communicate complex chemical and biological concepts in written feedback and reports.
  7. Experience participating in multidisciplinary and/or remote projects; familiarity with AI-assisted coding tools is a plus.