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Remote Senior Net Software Developer Jobs in Boston, MA

eClinical Solutions

Senior Software Engineer

Mansfield, MA · On-site +1

$129K - $171K/yr

NET- and Python-based systems * Designing and implementing AI-assisted workflows , copilots, or ... for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards ...

Architect.io

Senior Software Engineer (Remote)

Boston, MA · Remote

$125K - $165K/yr

  • Medical

  • Dental

DevOps, standardized write once, deploy everywhere Architect is a rapidly growing startup creating ... Software engineering @ Architect.io We are seeking a Senior Software Engineer to join our ...

Nasuni

Senior Software Engineer - File System

Boston, MA · On-site +1

$133K - $175K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Senior Software Engineer - File System Engineering | File System Team | Full-Time | US Boston ... Strong written communication skills for design docs, reviews, remote collaboration, and operational ...

AcuityMD

Senior Software Engineer, Applications

Boston, MA · Remote

$190K - $250K/yr

  • Medical

  • Dental

  • Vision

  • PTO

Senior Software Engineer, Applications AcuityMD is a software and data platform that accelerates ... Remote work : AcuityMD is committed to supporting full-remote flexibility for employees in the US.

Akamai Technologies, Inc

Senior Software Engineer

Cambridge, MA · On-site +1

$121K - $218K/yr

  • Medical

  • Life

  • Retirement

  • PTO

Become Akamai's next Senior Software Engineer As a Senior Software Engineer, you will develop ... Working across stakeholders - Product Management, Architecture, DevOps, and InfoSec to satisfy ...

Husch Blackwell Llp

Senior Software Engineer

Boston, MA · On-site +1

$133K - $175K/yr

  • Medical

  • Dental

  • Life

  • Retirement

  • PTO

The Senior Software Engineer designs, builds, and maintains the technical systems and application ... Principal Applicants Only. #LI-Remote #LI-KW1

Vista Higher Learning

Sr Full stack Software Engineer

Boston, MA · On-site +1

$140K - $150K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As a Senior Software Engineer here, you will join a Development team that is focused, professional ... Boston-Hybrid or Remote - Eastern US Time Zone Position requires current residence within the ...

Turnblock.io

Go Developer Remote USA (Fintech)

Boston, MA · Remote

$100K - $200K/yr

Experienced Software Engineer Our client is on crypto's cutting edge technology, and we're looking for the right engineers to join them. This is a remote position for any US candidate. No blockchain ...

Turnblock.io

Go Developer Remote US (Fintech)

Boston, MA · Remote

$100K - $200K/yr

Experienced Software Engineer Our client is on crypto's cutting edge technology, and we're looking for the right engineers to join them. This is a remote position for any US candidate. No blockchain ...

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All JobsNet Software Developer JobsRemote Senior Net Software Developer JobsRemote Senior Net Software Developer Jobs in Boston, MA

Remote Senior Net Software Developer information

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How much do remote senior net software developer jobs pay per hour?

As of Aug 15, 2026, the average hourly pay for remote senior net software developer in Boston, MA is $65.40, according to ZipRecruiter salary data. Most workers in this role earn between $57.45 and $73.12 per hour, depending on experience, location, and employer.

What is a remote senior .NET software developer?

A Remote Senior .NET Software Developer is an experienced professional responsible for designing, developing, and maintaining software applications using the .NET framework while working remotely. They collaborate with cross-functional teams, write clean and efficient code, and ensure software quality through testing and debugging. This role typically requires expertise in C#, ASP.NET, SQL, cloud platforms, and modern development methodologies. Strong problem-solving skills and the ability to work independently are essential.

What are the typical day-to-day responsibilities of a remote senior .NET software developer?

A Remote Senior Net Software Developer is typically responsible for designing, coding, and maintaining scalable .NET applications, troubleshooting technical issues, and optimizing performance. You will regularly participate in code reviews, collaborate with product managers and cross-functional teams, and mentor junior developers remotely. Many roles also involve integrating third-party services, contributing to architectural decisions, and ensuring code quality through automated testing. Successfully navigating these responsibilities requires proactive communication and effective time management to coordinate asynchronously in distributed teams.

What are the key skills and qualifications needed to thrive as a remote senior .NET software developer?

To excel as a Remote Senior Net Software Developer, you need deep expertise in C#, .NET frameworks, and software architecture, typically supported by a bachelor's degree in computer science or a related field and several years of experience in .NET development. Familiarity with version control systems like Git, cloud platforms such as Azure or AWS, and industry certifications (e.g., Microsoft Certified: .NET Developer) are often preferred. Strong problem-solving, effective communication, and the ability to work independently or collaborate within distributed teams are crucial soft skills. These competencies ensure that complex software projects are delivered efficiently, securely, and in alignment with business objectives in a remote work environment.

What are the most commonly searched types of Senior Net Software Developer jobs in Boston, MA?

The most popular types of Senior Net Software Developer jobs in Boston, MA are:

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For Remote Senior Net Software Developer jobs in Boston, MA, the most frequently searched job titles are:

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The top searched job categories for Remote Senior Net Software Developer jobs in Boston, MA are:

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Remote Senior Net Software Developer jobs near you
Infographic showing various Remote Senior Net Software Developer job openings in Boston, MA as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% Remote job distribution, with an average salary of $136,038 per year, or $65.4 per hour.

Senior Software Engineer

eClinical Solutions

Mansfield, MA • On-site, Remote

$129K - $171K/yr

Full-time

Re-posted 5 days ago

Job description

About eClinical Solutions
eClinical Solutions is transforming clinical development with elluminate®, our Clinical Data Cloud, helping life sciences organizations unify, analyze, and unlock the value of their data faster than ever before. By combining a modern cloud platform with expert data services, we empower smarter decisions across the clinical trial lifecycle-accelerating innovation that ultimately improves patient outcomes.
Our engineering teams build enterprise-grade, revenue-generating products at the intersection of cloud, data, analytics, and emerging AI technologies. If you're excited about building sophisticated software that makes a real-world impact on healthcare, this is the place to do it.
You will make an impact:
As a Senior Software Engineer, AI Enabled Platforms will be a member of the elluminate product development team. elluminate is a next generation data integration and analytics cloud platform that enables life sciences organizations to optimize the aggregation, standardization, and analysis of their data throughout the clinical development life cycle. You are primarily responsible for the design and development of core modules for the platform and will be involved in all phases of the software development lifecycle such as reviewing functional specifications, design, development, unit testing, code reviews and release management.
This role is ideal for an experienced engineer who enjoys hands-on development, mentoring others, and bringing modern capabilities-including AI-assisted and agentic workflows-into production-grade systems.
Accelerate your skills and career within a fast-growing company while impacting the future of healthcare.
Your day to day:
  • Design, develop, test, and deploy scalable, secure, and highly interactive web applications
  • Own and evolve core platform modules, from concept through release and support
  • Influence application and system architecture with a focus on performance, reliability, security, and maintainability
  • Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
  • Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
  • Provide technical mentorship and guidance to other engineers on the team
  • Diagnoses and resolves complex production issues across distributed systems
  • Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
  • Contribute to technical documentation including design specs, acceptance criteria, and release notes

Take the first step towards your dream career. Here is what we are looking for in this role.
AI & Modern Engineering Focus
We're actively incorporating AI-powered capabilities into our platform, and you'll help shape how this is done responsibly and effectively in an enterprise environment. This includes:
  • Integrating LLMs and AI services into .NET- and Python-based systems
  • Designing and implementing AI-assisted workflows, copilots, or intelligent automation features
  • Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation)
  • Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance
  • Collaborating with data and platform teams to operationalize AI-not just prototype it

Deep ML expertise is not required-we're looking for strong engineers who understand how to apply AI capabilities in real products.
What We're Looking For
  • Bachelor's or Master's degree in Computer Science or equivalent practical experience preferred
  • Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
  • 3-5 years of experience in software design and development using the Microsoft technology stack.
  • Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
  • Solid understanding of software design principles, patterns, and best practices
  • Experience across the full Software Development Lifecycle (Agile preferred)
  • Proven ability to work independently while collaborating effectively in a fast-paced environment
  • Excellent communication, documentation, and technical leadership skills

AI & Platform Experience
  • Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
  • Experience using Python and/or .NET alongside AI/LLM workflows
  • Familiarity with agent-based or workflow-driven AI architectures is a strong plus
  • Understanding of secure and responsible AI usage in enterprise systems

Nice to Have
  • Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
  • Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
  • Secure development experience, including awareness of common vulnerabilities and mitigations
  • Experience with clinical trial data, life sciences, or regulated SaaS environments
  • Experience building data visualizations or analytics-driven user experiences

Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours!
eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here: https://topworkplaces.com/company/eclinical-solutions/
eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here!
We are proud to be an equal opportunity employer that values diversity. Our management team is committed to the principle that employment decisions are based on qualifications, merit, culture fit and business need.
#LI-AB1
Pay Range
US Pay Ranges
$132,000-$165,000 USD

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