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Remote Principal Software Engineer Net Jobs (NOW HIRING)

KBR

Principal Software Engineer

El Segundo, CA · On-site +1

$143K - $192K/yr

Principal Software Engineer Belong. Connect. Grow. with KBR! KBR is seeking an experienced Principal Software Engineer to support the MSEIT contract at Space Systems Command (SSC). This role combines ...

Upstart

Principal Software Engineer

OR · On-site +1

$134K - $180K/yr

As a Principal Software Engineer, you will provide technical leadership across a growing portfolio ... Remote Time Zone Requirements - This team operates on the East/West Coast time zones. Travel ...

Insight

$133K - $178K/yr

You will have the flexibility to work fully remote from anywhere across the US. Insight at a Glance ... About the role As a Principal Software Engineer (PSE), AI Solutions, you will play a senior, hands ...

Cotality

Principal Software Engineer (Python)

Austin, TX · On-site +1

$133K - $179K/yr

The hybrid-remote Principal Software Development Engineer leads the design, development, and testing of complex software systems and applications. This senior-level position is responsible for ...

Cotality

Principal Software Engineer (Python)

Irvine, CA · On-site +1

$144K - $194K/yr

The hybrid-remote Principal Software Development Engineer leads the design, development, and testing of complex software systems and applications. This senior-level position is responsible for ...

Cotality

Principal Software Engineer (Python)

Oxford, MS · On-site +1

$127K - $170K/yr

The hybrid-remote Principal Software Development Engineer leads the design, development, and testing of complex software systems and applications. This senior-level position is responsible for ...

Cotality

Principal Software Engineer (Python)

Sunrise, FL · On-site +1

$128K - $172K/yr

The hybrid-remote Principal Software Development Engineer leads the design, development, and testing of complex software systems and applications. This senior-level position is responsible for ...

Cotality

Principal Software Engineer (Python)

Dallas, TX · On-site +1

$133K - $179K/yr

The hybrid-remote Principal Software Development Engineer leads the design, development, and testing of complex software systems and applications. This senior-level position is responsible for ...

Tendo

Principal Software Engineer

San Francisco, CA · Remote

$157K - $212K/yr

Additionally, the Principal Software Engineer will bring deep expertise in one or more technologies including React, TypeScript, Go, Ent, gRPC, Twirp, and/or AWS technologies like EventBridge and ...

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How much do remote principal software engineer net jobs pay per year?

As of Jun 29, 2026, the average yearly pay for remote principal software engineer net in the United States is $160,936.00, according to ZipRecruiter salary data. Most workers in this role earn between $135,000.00 and $181,000.00 per year, depending on experience, location, and employer.
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Remote Principal Software Engineer Net jobs near you
Infographic showing various Remote Principal Software Engineer Net job openings in the United States as of June 2026, with employment types broken down into 95% Full Time, 2% Part Time, and 3% Contract. Highlights an 37% Physical, 3% Hybrid, and 60% Remote job distribution, with an average salary of $160,936 per year, or $77.4 per hour.
Principal Software Engineer

Principal Software Engineer

eClinical Solutions

Mansfield, MA • On-site, Remote

$142K - $191K/yr

Full-time

Posted 21 days ago

Key responsibilities

  • Design, develop, test, and deploy scalable, secure, and highly interactive web applications.

  • Own and evolve core platform modules from concept through release and support.

  • Integrate LLMs and AI services into .NET- and Python-based systems and design AI-assisted workflows.

Job description

About eClinical Solutions
eClinical Solutions is transforming clinical development with elluminate®, our Clinical Data Cloud, helping life sciences organizations unify, analyze, and unlock the value of their data faster than ever before. By combining a modern cloud platform with expert data services, we empower smarter decisions across the clinical trial lifecycle-accelerating innovation that ultimately improves patient outcomes.
Our engineering teams build enterprise-grade, revenue-generating products at the intersection of cloud, data, analytics, and emerging AI technologies. If you're excited about building sophisticated software that makes a real-world impact on healthcare, this is the place to do it.
You will make an impact:
As a Principal Full Stack Software Engineer, you will be a technical leader within the elluminate Product Development team. You'll help design and build the core services and user experiences of a next-generation clinical data and analytics platform-while influencing architecture, engineering standards, and technical direction.
This role is ideal for an experienced engineer who enjoys hands-on development, mentoring others, and bringing modern capabilities-including AI-assisted and agentic workflows-into production-grade systems.
Your day to day:
  • Design, develop, test, and deploy scalable, secure, and highly interactive web applications
  • Own and evolve core platform modules, from concept through release and support
  • Influence application and system architecture with a focus on performance, reliability, security, and maintainability
  • Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
  • Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
  • Provide technical mentorship and guidance to other engineers on the team
  • Diagnoses and resolves complex production issues across distributed systems
  • Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
  • Contribute to technical documentation including design specs, acceptance criteria, and release notes

AI & Modern Engineering Focus
We're actively incorporating AI-powered capabilities into our platform, and you'll help shape how this is done responsibly and effectively in an enterprise environment. This includes:
  • Integrating LLMs and AI services into .NET- and Python-based systems
  • Designing and implementing AI-assisted workflows, copilots, or intelligent automation features
  • Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation)
  • Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance
  • Collaborating with data and platform teams to operationalize AI-not just prototype it

Deep ML expertise is not required-we're looking for strong engineers who understand how to apply AI capabilities in real products.
Take the first step toward your dream career. Here is what we are looking for in this role.
Qualifications:
  • Bachelor's or Master's degree in Computer Science or equivalent practical experience
  • 10+ years in software design and development using the Microsoft technology stack preferred
  • Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
  • Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
  • Solid understanding of software design principles, patterns, and best practices
  • Experience across the full Software Development Lifecycle (Agile preferred)
  • Proven ability to work independently while collaborating effectively in a fast-paced environment
  • Excellent communication, documentation, and technical leadership skills

AI & Platform Experience
  • Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
  • Experience using Python and/or .NET alongside AI/LLM workflows
  • Familiarity with agent-based or workflow-driven AI architectures is a strong plus
  • Understanding of secure and responsible AI usage in enterprise systems

Nice to Have
  • Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
  • Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
  • Secure development experience, including awareness of common vulnerabilities and mitigations
  • Experience with clinical trial data, life sciences, or regulated SaaS environments
  • Experience building data visualizations or analytics-driven user experiences

Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours!
eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here: https://topworkplaces.com/company/eclinical-solutions/
eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here!
We are proud to be an equal opportunity employer that values diversity. Our management team is committed to the principle that employment decisions are based on qualifications, merit, culture fit and business need.
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Pay Range
US Pay Ranges
$152,000-$190,000 USD

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