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Remote Principal Data Architect Jobs in Reston, VA

BullFrog AI Holdings, Inc.

Principal Data Scientist

Gaithersburg, MD · On-site +1

$175K - $215K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

BullFrog AI is seeking an exceptional Principal Data Scientist with a strong background in ... Collaborate effectively with distributed, remote teams to ensure seamless communication and on-time ...

Bixal

Principal Data Lead

Fairfax, VA · On-site +1

$160K - $200K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Bixal is seeking a Principal Data Lead to help lead the strategy, governance, and quality of data ... Govern the promotion of data through a tiered catalog architecture (e.g., raw, source, and trusted ...

Parsons

Data Analytics Architect

Alexandria, VA · On-site +1

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

The Data Analytics Architect leads the design, integration, and governance of data systems that ... FAA Part 107 Remote Pilot Certification (required) Physical Requirements / Working Conditions ...

Bigbear.ai

Applications Architect

Mclean, VA · Remote

$175K - $220K/yr

This role bridges the Chief Data Architect's schema and data flow designs with the ServiceNow ... This position is remote but will require travel in the DMV area. Responsibilities * Own and evolve ...

Deckers

Director, Data Architecture

Washington, DC · On-site +1

United States (Remote) Interested applicants must reside in one of the following approved states ... architect of Deckers' data future-defining, governing, and evolving our enterprise data ...

Humana

Principal Anaplan Solutions Architect

Washington, DC · On-site +1

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Ensure compliance with data privacy, security, and governance standards (e.g., GDPR, HIPAA, SOX). * ... Travel: While this is a remote position, occasional travel to Humana's offices for training or ...

Humana

Principal Anaplan Solutions Architect

Washington, DC · On-site +1

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Ensure compliance with data privacy, security, and governance standards (e.g., GDPR, HIPAA, SOX). * ... Travel: While this is a remote position, occasional travel to Humana's offices for training or ...

Humana

Principal Anaplan Solutions Architect

Washington, DC · On-site +1

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Ensure compliance with data privacy, security, and governance standards (e.g., GDPR, HIPAA, SOX). * ... Travel: While this is a remote position, occasional travel to Humana's offices for training or ...

Wsgr

Principal Solutions Engineer

Washington, DC · On-site +1

This position is available as a hybrid or fully remote work schedule. Responsibilities: Solution ... Partner with KM/Data teams to architect data pipelines, authoritative sources, and governed ...

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All JobsPrincipal Data Architect JobsRemote Principal Data Architect JobsRemote Principal Data Architect Jobs in Reston, VA

Remote Principal Data Architect information

See Reston, VA salary details

$111.3K

$173.2K

$225.8K

How much do remote principal data architect jobs pay per year?

As of Aug 19, 2026, the average yearly pay for remote principal data architect in Reston, VA is $173,221.00, according to ZipRecruiter salary data. Most workers in this role earn between $147,200.00 and $199,700.00 per year, depending on experience, location, and employer.

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Remote Principal Data Architect jobs near you
Infographic showing various Remote Principal Data Architect job openings in Reston, VA as of August 2026, with employment types broken down into 1% As Needed, 84% Full Time, 11% Part Time, and 4% Contract. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $173,221 per year, or $83.3 per hour.

Principal Data Scientist

BullFrog AI Holdings, Inc.

Gaithersburg, MD • On-site, Remote

$175K - $215K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 10 days ago

Job description

Job Type
Full-time
Description
About BullFrog AI
BullFrog AI (NASDAQ: BFRG) is a computational biology company spun out of the Johns Hopkins Applied Physics Laboratory. We sit at the intersection of AI and drug discovery, building platforms that help pharmaceutical and biotech companies make better, faster decisions across the drug development lifecycle:
  • bfPREP™ - biology-aware data harmonization that unlocks the value trapped in fragmented, multi-site clinical and omics datasets
  • bfLEAP™ - causal AI analytics for patient subgroup discovery, biomarker identification, and drug target prioritization
  • bfARENAS™ - structured multi-criteria decision support for high-stakes portfolio, indication, and go/no-go decisions

The Role
Help turn complex biomedical and clinical data into defensible decisions for drug discovery and development.
BullFrog AI is seeking an exceptional Principal Data Scientist with a strong background in biomedical analytics. This is a senior individual contributor role that combines client-facing project leadership with direct contributions to BullFrog's in-house platform - spanning target discovery, patient subtyping, and multimodal data analysis.
Day-to-day work is client-dependent, with each engagement bringing a different analytical challenge. You will be expected to lead from execution and bring scientific rigor, technical depth, and clear communication to every project.
What You'll Do
Client Engagement & Project Leadership
  • Own end-to-end analytical workstreams across target discovery, patient subtyping, and multimodal data exploration
  • Translate complex data science findings into clear, actionable insights for non-technical stakeholders and senior leadership
  • Collaborate effectively with distributed, remote teams to ensure seamless communication and on-time delivery

Technical Delivery
  • Design, implement, and optimize AI/ML models using diverse healthcare data types, including omics, claims, and EHR
  • Conduct multi-omic analyses such as RNA-seq differential expression, clustering, genomic association analysis, and biomarker discovery
  • Implement NLP and LLM solutions tailored to life sciences datasets
  • Contribute to the development and refinement of BullFrog's in-house platform capabilities

Requirements
What We're Looking For
Education
• Advanced degree (MS or PhD) in a quantitative field - biology, computer science, engineering, or related
Experience
• 5+ years of post-graduate experience in life sciences analytics in pharma, biotech, or consulting
• Demonstrated proficiency in Python; production-quality code in a research or commercial environment
• Hands-on experience with major healthcare data types - omics data required; claims and EHR experience strongly preferred
• Hands-on experience applying LLMs or NLP to real analytical workflows, ideally biomedical or clinical text extraction, summarization, evaluation, or retrieval
• Proven track record of collaborating effectively with remote teams
• Must be legally authorized to work in the United States
Desired Skills
• Prior experience in multi-modal analysis with deep learning
• Causal inference experience - a significant differentiator for this role
• NLP/LLM expertise applied to life sciences and healthcare text
• Strong foundation in data engineering and databases
• Experience with graph-based approaches: feature engineering, ML, and visualization
• Cloud platform experience, particularly AWS or Google Cloud
Who Will Thrive Here
• Intellectually versatile - energized by moving across problem types, data modalities, and scientific domains
• Client-ready - comfortable presenting to and partnering with senior scientific and business stakeholders
• Independently driven - able to scope, execute, and deliver complex analyses without heavy oversight
• Scientifically rigorous - you hold your work to a publication-quality standard even in a commercial environment
• Collaborative by default - remote-first is second nature; you communicate proactively and close loops
What We Offer
Base salary range: $175,000 - $210,000 per year, based on level of education, years of relevant experience, skills, and location. This role is eligible for performance bonus and equity/stock options, subject to company and plan terms. Benefits include medical, dental, and vision from day one, short-term disability, 401(k) from first paycheck, 15 days PTO, 11 paid holidays annually, and maternity and paternity leave.
BullFrog AI is an equal opportunity employer. We are committed to building a diverse team that reflects the communities and patients our work ultimately serves.
Advancing medicine through artificial intelligence.
Salary Description
$175,000 - $215,000 annually

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