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Remote Full Stack Software Developer Jobs in Natick, MA

eClinical Solutions

Principal Software Engineer

Mansfield, MA · On-site +1

$142K - $191K/yr

As a Principal Full Stack Software Engineer , you will be a technical leader within the elluminate ... for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards ...

eClinical Solutions

Principal Software Engineer

Mansfield, MA · On-site +1

$142K - $191K/yr

As a Principal Full Stack Software Engineer , you will be a technical leader within the elluminate ... for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards ...

eClinical Solutions

Principal Software Engineer

Mansfield, MA · On-site +1

$142K - $191K/yr

As a Principal Full Stack Software Engineer , you will be a technical leader within the elluminate ... for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards ...

eClinical Solutions

Principal Software Engineer

Mansfield, MA · On-site +1

$142K - $191K/yr

As a Principal Full Stack Software Engineer , you will be a technical leader within the elluminate ... for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards ...

Aquila Technology

Software Developer

Lexington, MA · On-site +1

REMOTE At Aquila Technology, you will see our team's passion every day, whether we are building a ... have full-stack development experience. Must Have * Degree Level: Bachelor's Degree * 5 years ...

Aquila Technology

Software Developer

Lexington, MA · On-site +1

REMOTE At Aquila Technology, you will see our team's passion every day, whether we are building a ... have full-stack development experience. Must Have * Degree Level: Bachelor's Degree * 5 years ...

Enigma Aerospace

Senior Software Engineer

Burlington, MA · On-site +1

$133K - $175K/yr

This is a key engineering role on a deeply technical team building the most capable runway ... Development on the full-stack software system architecture and interfaces across frontend, backend ...

Enigma Aerospace

Senior Software Engineer

Burlington, MA · On-site +1

$133K - $175K/yr

This is a key engineering role on a deeply technical team building the most capable runway ... Development on the full-stack software system architecture and interfaces across frontend, backend ...

Tuesday Health

Software Developer

Boston, MA · Remote

Full Stack Delivery * Build Blazor WASM components with clean, reusable patterns and accessibility ... Remote work with multiple onsite sessions each year to maximize collaboration and team building * A ...

Zobility

Be Seen First

Full Stack Java Developer

Andover, MA · Remote

$65 - $70/hr

Full stack development role within the last 2 years * Java * Spring * Angular * RxJS/REACT * Ability to design and code without the support of AI tools Preferred: * AG-Grid * RESTful APIs * MariaDB

ICONSTAFF

Backend Engineer/FullStack

Cambridge, MA · On-site +1

$140K - $220K/yr

Full-Stack Engineer | AI/ML Start-up | Competitive Salary + Equity We're partnering with a fast ... Remote work stipend * Generous PTO Next Steps If you're interested in working on challenging ...

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How much do remote full stack software developer jobs pay per hour?

As of Jul 17, 2026, the average hourly pay for remote full stack software developer in Natick, MA is $61.18, according to ZipRecruiter salary data. Most workers in this role earn between $50.87 and $70.48 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Remote Full Stack Software Developer position, and why are they important?

A Remote Full Stack Software Developer needs strong programming expertise in both front-end (HTML, CSS, JavaScript frameworks) and back-end technologies (such as Node.js, Python, Java), often supported by a relevant degree or equivalent experience. Familiarity with version control systems (like Git), cloud services (such as AWS or Azure), databases, and common frameworks (React, Angular, Django, etc.) is highly valued, and certifications in these areas can be advantageous. Effective communication, time management, and self-motivation are critical soft skills for collaborating with distributed teams and managing tasks independently. These competencies enable developers to deliver robust, scalable software solutions while navigating the challenges of remote work environments.

What does the typical workday look like for a Remote Full Stack Software Developer?

Remote Full Stack Software Developers usually start their day with a virtual stand-up meeting to align with team members on project progress and priorities. Throughout the day, they split their time between front-end and back-end development tasks, debugging, code reviews, and collaborating via chat or video calls. They often work independently but are expected to stay responsive to team communications and contribute to agile workflows. A typical week may also include planning sessions, knowledge sharing, and opportunities to mentor or be mentored by peers. This structure allows for both autonomy and meaningful collaboration within a supportive remote team environment.

What is a Remote Full Stack Software Developer job?

A Remote Full Stack Software Developer is responsible for building and maintaining both the front-end and back-end of web applications while working from a remote location. They work with various technologies, including databases, APIs, server-side programming, and client-side frameworks, to create fully functional applications. This role requires strong problem-solving skills, knowledge of multiple programming languages, and the ability to collaborate with remote teams using communication and project management tools.

What are the most commonly searched types of Full Stack Software Developer jobs in Natick, MA? The most popular types of Full Stack Software Developer jobs in Natick, MA are:
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Remote Full Stack Software Developer jobs near you
Principal Software Engineer

Principal Software Engineer

eClinical Solutions

Mansfield, MA • On-site, Remote

$142K - $191K/yr

Full-time

Re-posted 10 days ago

Job description

About eClinical Solutions
eClinical Solutions is transforming clinical development with elluminate®, our Clinical Data Cloud, helping life sciences organizations unify, analyze, and unlock the value of their data faster than ever before. By combining a modern cloud platform with expert data services, we empower smarter decisions across the clinical trial lifecycle-accelerating innovation that ultimately improves patient outcomes.
Our engineering teams build enterprise-grade, revenue-generating products at the intersection of cloud, data, analytics, and emerging AI technologies. If you're excited about building sophisticated software that makes a real-world impact on healthcare, this is the place to do it.
You will make an impact:
As a Principal Full Stack Software Engineer, you will be a technical leader within the elluminate Product Development team. You'll help design and build the core services and user experiences of a next-generation clinical data and analytics platform-while influencing architecture, engineering standards, and technical direction.
This role is ideal for an experienced engineer who enjoys hands-on development, mentoring others, and bringing modern capabilities-including AI-assisted and agentic workflows-into production-grade systems.
Your day to day:
  • Design, develop, test, and deploy scalable, secure, and highly interactive web applications
  • Own and evolve core platform modules, from concept through release and support
  • Influence application and system architecture with a focus on performance, reliability, security, and maintainability
  • Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
  • Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
  • Provide technical mentorship and guidance to other engineers on the team
  • Diagnoses and resolves complex production issues across distributed systems
  • Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
  • Contribute to technical documentation including design specs, acceptance criteria, and release notes

AI & Modern Engineering Focus
We're actively incorporating AI-powered capabilities into our platform, and you'll help shape how this is done responsibly and effectively in an enterprise environment. This includes:
  • Integrating LLMs and AI services into .NET- and Python-based systems
  • Designing and implementing AI-assisted workflows, copilots, or intelligent automation features
  • Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation)
  • Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance
  • Collaborating with data and platform teams to operationalize AI-not just prototype it

Deep ML expertise is not required-we're looking for strong engineers who understand how to apply AI capabilities in real products.
Take the first step toward your dream career. Here is what we are looking for in this role.
Qualifications:
  • Bachelor's or Master's degree in Computer Science or equivalent practical experience
  • 10+ years in software design and development using the Microsoft technology stack preferred
  • Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
  • Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
  • Solid understanding of software design principles, patterns, and best practices
  • Experience across the full Software Development Lifecycle (Agile preferred)
  • Proven ability to work independently while collaborating effectively in a fast-paced environment
  • Excellent communication, documentation, and technical leadership skills

AI & Platform Experience
  • Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
  • Experience using Python and/or .NET alongside AI/LLM workflows
  • Familiarity with agent-based or workflow-driven AI architectures is a strong plus
  • Understanding of secure and responsible AI usage in enterprise systems

Nice to Have
  • Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
  • Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
  • Secure development experience, including awareness of common vulnerabilities and mitigations
  • Experience with clinical trial data, life sciences, or regulated SaaS environments
  • Experience building data visualizations or analytics-driven user experiences

Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours!
eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here: https://topworkplaces.com/company/eclinical-solutions/
eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here!
We are proud to be an equal opportunity employer that values diversity. Our management team is committed to the principle that employment decisions are based on qualifications, merit, culture fit and business need.
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Pay Range
US Pay Ranges
$152,000-$190,000 USD

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