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Python Backend Developer Remote Jobs in San Diego, CA

Singular Genomics

Software Engineer

San Diego, CA · On-site +1

If remote, travel to the headquarters in San Diego, CA will be required at least quarterly ... Solid Python skills; comfortable working in a large, production codebase with real operational ...

MoneyThumb

Java Engineer I, 100% Remote

San Diego, CA · On-site +1

$55 - $75.50/hr

We're looking for an awesome back-end Java engineer with Machine Learning or AI experience to help us take it to the next level. What you'll do: You'll work in a small, collaborative team on our core ...

PickTrace

Senior Software Engineer

San Diego, CA · Remote

$115K - $140K/yr

Work full stack across the back end and front end * Write efficient, scalable, and easily testable ... High level languages similar to Go, Kotlin, C#, Python, Java * Front end languages similar to HTML ...

Adidev Technologies Inc

IOSDeveloper

San Diego, CA · On-site +1

$30 - $40/hr

Must be open to working onsite, no telecommuting/remote positions are being offered. Must be a ... As an iOS or Android Mobile Developer for Adidev Technologies Inc., you will be enhancing and ...

Shield AI

Principal Engineer, Software (R5285)

San Diego, CA · On-site +1

$143K - $192K/yr

... back-end for interaction with Pilot; and a web-application UI for mission planning, command and ... Typescript, C++, Go, Python, Rust,etc.). * Strong knowledge of modern software engineering best ...

PickTrace

Senior Software Engineer

San Diego, CA · On-site +1

$115K - $140K/yr

Work full stack across the back end and front end * Write efficient, scalable, and easily testable ... High level languages similar to Go, Kotlin, C#, Python, Java * Front end languages similar to HTML ...

Waymo

Senior System Test Engineer, Perception

San Diego, CA · On-site +1

$110K - $151K/yr

... when remote assistance is needed, across multiple platforms and in support of rapid ... Experience in data analysis/modeling or software engineering using Python and SQL * Solid written ...

Teradata

Senior Staff AI Engineer - 220323

San Diego, CA · On-site +1

$199K - $249K/yr

... developer facing AI systems. You will operate with a high degree of autonomy, partner closely with ... Strong proficiency in Java, Go, or Python , with experience building largescale services. * Deep ...

Arctiq

Senior Site Reliability Engineer

San Diego, CA · Remote

$58.25 - $77.50/hr

This is a remote, contract opportunity for a project Arctiq is delivering for a client. Candidates ... or DevOps, with significant experience in distributed systems. * Expertise in Go, Python, or Java ...

Arctiq, Inc.

Senior Site Reliability Engineer

San Diego, CA · Remote

$60.50 - $80.50/hr

This is a remote, contract opportunity for a project Arctiq is delivering for a client. Candidates ... or DevOps, with significant experience in distributed systems. * Expertise in Go, Python, or Java ...

Teradata

Cloud Control Plane Engineer - 220396

San Diego, CA · On-site +1

$132K - $166K/yr

Programming experience in a backend language (e.g., Go, Java, Python, or similar). * Experience designing systems with scalability, reliability, and strong cost-performance characteristics. * Comfort ...

Raven Solutions, LLC

SRE / Platform Engineer

San Diego, CA · Remote

$124K - $160K/yr

Remote Wellness Days : Federal Holidays Observed AWS Site Reliability Engineer will be responsible ... Proficiency in programing languages (e.g., Bash, Python,.net, ) and infrastructure-as-code tools (e ...

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Showing results 21-40

All JobsPython Backend Developer JobsPython Backend Developer Remote JobsPython Backend Developer Remote Jobs in San Diego, CA

Python Backend Developer Remote information

See San Diego, CA salary details

$17K

$157.4K

$202.8K

How much do python backend developer remote jobs pay per year?

As of Aug 26, 2026, the average yearly pay for python backend developer remote in San Diego, CA is $157,381.00, according to ZipRecruiter salary data. Most workers in this role earn between $154,500.00 and $177,800.00 per year, depending on experience, location, and employer.

What does a Python backend developer do?

A remote Python Backend Developer designs, builds, and maintains the server-side logic of web applications using the Python programming language. They are responsible for developing APIs, managing databases, ensuring application performance, and integrating third-party services. Working remotely, they collaborate with front-end developers, DevOps, and other team members through online tools to deliver scalable and reliable software solutions.

How does a Python backend developer typically collaborate with front-end developers and other team members in a remote setting?

As a remote Python Backend Developer, you'll frequently collaborate with front-end developers, DevOps engineers, and product managers using tools like Slack, Jira, and GitHub. Regular stand-up meetings and code reviews help ensure alignment on project goals and timelines. You'll often work closely with front-end developers to design APIs, resolve integration issues, and implement new features, requiring clear communication and thorough documentation. Effective collaboration in a remote environment relies on proactive updates, responsive communication, and a strong understanding of team workflows.

What are the key skills and qualifications needed to thrive as a Python backend developer, and why are they important?

To thrive as a Python Backend Developer (Remote), you need strong proficiency in Python programming, knowledge of backend frameworks (such as Django or Flask), and experience with database management, often supported by a degree in computer science or related field. Familiarity with version control systems like Git, RESTful API design, and cloud platforms (e.g., AWS or Azure) is typically required. Excellent problem-solving abilities, self-motivation, and effective remote communication skills set top developers apart. These skills ensure robust, scalable backend solutions are delivered efficiently while collaborating seamlessly with distributed teams.

What is the difference between Python Backend Developer Remote vs Python Web Developer?

AspectPython Backend Developer RemotePython Web Developer
Required SkillsPython, Django/Flask, REST APIs, databasesPython, Django/Flask, HTML/CSS, JavaScript
Work EnvironmentRemote, independent or team-basedRemote or on-site, often collaborative
Industry UsageTech, startups, SaaS companiesWeb development agencies, tech firms
CertificationsPython certifications, web frameworksPython certifications, web development courses

Both roles involve Python programming and web development skills, but Python Backend Developers focus on server-side logic, APIs, and databases, often working remotely. Python Web Developers may have a broader skill set including front-end technologies and may work in various environments. The roles overlap significantly, but the backend role emphasizes server-side architecture.

How much do remote Python backend developers make?

Remote Python backend developers typically earn between $80,000 and $130,000 annually, depending on experience, location, and company size. Senior roles or those requiring specialized skills like Django or Flask may offer higher salaries, especially with additional certifications or cloud experience.

Is Python backend developer in demand?

Python backend developers are in high demand due to the language's versatility, ease of use, and widespread adoption in web development, data science, and automation. Many companies seek professionals skilled in frameworks like Django and Flask, along with knowledge of REST APIs and database integration, making this a strong career choice with good job prospects.

What are popular job titles related to Python Backend Developer Remote jobs in San Diego, CA?

For Python Backend Developer Remote jobs in San Diego, CA, the most frequently searched job titles are:

What job categories do people searching Python Backend Developer Remote jobs in San Diego, CA look for?

The top searched job categories for Python Backend Developer Remote jobs in San Diego, CA are:

What cities near San Diego, CA are hiring for Python Backend Developer Remote jobs?

Cities near San Diego, CA with the most Python Backend Developer Remote job openings:

Python Backend Developer Remote jobs near you
Infographic showing various Python Backend Developer Remote job openings in San Diego, CA as of August 2026, with employment types broken down into 1% Internship, 89% Full Time, 6% Part Time, and 4% Contract. Highlights an 76% Physical, 6% Hybrid, and 18% Remote job distribution, with an average salary of $157,381 per year, or $75.7 per hour.

Software Engineer

Singular Genomics

San Diego, CA • On-site, Remote

Full-time

Posted 16 days ago

Job description

ABOUT SINGULAR GENOMICS
Singular Genomics is inventing at the forefront of genomics, one of the world's fastest-growing industries. The commercially available G4® Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In addition, the company is currently developing the G4X™ Spatial Sequencer, an upgrade to the G4, which will leverage Singular's proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context. Singular Genomics' mission is to empower researchers and clinicians to advance science and medicine.
We foster a culture of creativity and technical excellence, both catalysts for innovation. We celebrate diversity, emphasize collaboration and, as we rapidly mature, we are constantly looking at ways we can do better for our people.
Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub. Our Manufacturing facility is in Sorrento Valley.
Position Summary:
We're looking for a Software Engineer to join our core software team and contribute across pipeline engineering, operational tooling, and field support. This is a generalist role, where you will be embedded in the team that builds and maintains our core sequencing analysis platform, and you'll help keep that platform healthy and the team around it moving fast. On any given day, that might mean fixing a bug in the image backup pipeline, triaging a failed sequencing run reported by the field team, improving panel validation logic, or maintaining the build and regression infrastructure that the team depends on. You don't need deep expertise in any one niche, you need solid Python fundamentals, a get-things-done orientation, and the judgment to work confidently across a large, real production codebase.
This position can be remote or on-site. If remote, travel to the headquarters in San Diego, CA will be required at least quarterly.
Responsibilities:
  • Contribute to active development on the sequencing analysis pipeline in Python, including bug fixes, feature work, and code reviews.
  • Own and maintain build configuration, CI/CD pipelines, and regression infrastructure (Jenkins, Bitbucket, HPC).
  • Respond to inbound triage requests from the field and internal teams, diagnosing and resolving pipeline failures on sequencing instruments.
  • Develop and maintain operational tooling including re-run utilities, job monitoring, and pipeline configuration management.
  • Work on data handling features including backup/upload logic, panel management, and sample sheet validation.
  • Implement locking, concurrency controls, and other reliability improvements to the pipeline execution framework.
  • Support package management and dependency maintenance across Python and JavaScript/TypeScript projects.
  • Develop and maintain lightweight web services, internal APIs, and database-backed tooling to support engineering and field operations.
  • Identify and close gaps in observability, documentation, and operational processes.

Required Qualifications:
  • 2-5 years of professional software engineering experience.
  • Solid Python skills; comfortable working in a large, production codebase with real operational requirements.
  • Familiarity with Linux, HPC environments, and distributed job execution.
  • Experience with build systems, CI/CD pipelines, and package tooling (e.g., Jenkins,
    Bitbucket, Poetry).
  • Comfortable reading and debugging across a broad codebase, including relational databases, web services and pipeline orchestration (Airflow or similar).
  • Working knowledge of JavaScript and openness to learning TypeScript.
  • Strong debugging instincts and the ability to triage ambiguous failures under time pressure.
  • Good communication and collaboration skills in a team environment.

Preferred Qualifications:
  • Familiarity with genomics, sequencing data, or scientific computing pipelines (Numpy, Scipy, RAPIDS, POLARS, etc).
  • Experience with PostGRES, celery and Flask.
  • Exposure to Django or similar Python web frameworks.
  • Experience with Docker and containerized workflows.
  • Familiarity with Airflow or other workflow orchestration systems.

The estimated base salary range for this role based in the United States of America is: $108,400 - $127,500. Additionally, this role is eligible for to receive equity as part of the compensation package. Compensation decisions are dependent on several factors including, but not limited to, an individual's qualifications, location where the role is to be performed, internal equity, and alignment with market data. Should the level of the role change during the hiring process, the applicable salary range may be updated accordingly.
Singular Genomics is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Singular Genomics is committed to working with and providing reasonable accommodations to job applicants with physical or mental disabilities. Applicants with a disability who require a reasonable accommodation for any part of the application or hiring process can provide their name and contact information to our Accommodations team at accommodationsrequest@singulargenomics.com. Your request will be responded to as soon as possible.

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