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Protein Structural Biology Jobs (NOW HIRING)

Output Biosciences

Head of Biology

New York, NY · On-site

$120K - $250K/yr

You have structural biology expertise, including protein structure analysis and structure-function relationships * You have experience with active learning or iterative experimental design in a ...

Output, Inc

Head of Biology

New York, NY · On-site

$120K - $250K/yr

You have structural biology expertise, including protein structure analysis and structure-function relationships * You have experience with active learning or iterative experimental design in a ...

Pfizer, Inc.

Senior Scientist

San Diego, CA · On-site

$93K - $156K/yr

Collaborate with colleagues in Structural Biology and Protein Sciences, Medicinal Chemistry, Biophysics, Enzymology and Computational Chemistry, serving as protein sciences and structural biology ...

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Protein Structural Biology information

What is protein structural biology?

Protein structural biology is a scientific field that focuses on understanding the three-dimensional structure of proteins at the molecular level. Researchers in this area use techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy to determine how proteins are shaped and how these shapes relate to their functions in the body. This knowledge helps us understand biological processes, develop new medicines, and design better enzymes for industrial use. Protein structural biology is essential for uncovering how proteins work and how changes in their structure can lead to diseases.

What is the difference between Protein Structural Biology vs Protein Biochemist?

AspectProtein Structural BiologyProtein Biochemist
Required CredentialsTypically PhD in Biochemistry, Structural Biology, or related fieldsUsually PhD or Master's in Biochemistry, Molecular Biology, or related fields
Work EnvironmentResearch labs, academic institutions, biotech companies focusing on structure determinationLaboratories, research institutions, industry settings focusing on protein function and interactions
Employer & Industry UsageAcademic research, pharmaceutical, biotech companiesPharmaceutical, biotech, research institutions

Protein Structural Biology focuses on determining the 3D structures of proteins using techniques like X-ray crystallography and cryo-EM, while Protein Biochemists study protein functions, interactions, and activities. Both roles require advanced degrees and often collaborate, but their primary goals differ: one emphasizes structure, the other function.

What are the key skills and qualifications needed to thrive as a Protein Structural Biologist, and why are they important?

To thrive as a Protein Structural Biologist, you need a strong background in molecular biology, biochemistry, and structural analysis techniques, typically supported by a Ph.D. or relevant research experience. Familiarity with technical tools such as X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, and molecular modeling software is essential. Critical thinking, attention to detail, and effective collaboration skills distinguish outstanding professionals in this field. These competencies enable accurate structure determination and interpretation, which are vital for advancing scientific understanding and drug discovery.

What are some typical challenges faced when working in a protein structural biology lab?

One common challenge in protein structural biology is obtaining high-quality, pure protein samples in sufficient quantities, as this step is critical for successful structural studies. Troubleshooting issues such as protein instability, aggregation, or low expression levels often requires iterative optimization and close collaboration with molecular biologists and biochemists. Additionally, interpreting complex structural data from techniques like X-ray crystallography or cryo-EM can be time-consuming and requires strong attention to detail. Despite these challenges, the collaborative and interdisciplinary nature of the work provides valuable learning opportunities and exposure to cutting-edge technologies.
Postdoctoral Research Associate - Structural Biology

Postdoctoral Research Associate - Structural Biology

St. Jude Children's Research Hospital

Memphis, TN • On-site

$72K/yr

Full-time

Posted 15 days ago

St. Jude Children's Research Hospital rating

8.4

Company rating: 8.4 out of 10

Based on 9 frontline employees who took The Breakroom Quiz

62nd of 995 rated hospitals

Job description

A postdoctoral research associate position is available in the lab of Tanja Mittag in the Department of Structural Biology.
Project Description:
The Mittag lab invites applications for a Postdoctoral Research Fellow to work on structures of the tumor suppressor and ubiquitin ligase component SPOP. We have recently solved the first cryo-EM structures of full-length SPOP (Cuneo et al. Mol Cell 2023), and they have revealed interfaces that had not recently been observed in structures of smaller constructs. Importantly, these interfaces are lined with cancer mutations whose molecular mechanisms were not previously understood, but now provide molecular explanations for pathophysiological mechanisms. We have also revealed that certain mutations lead to large changes in quaternary assembly. The project provides opportunities for characterizing structures of SPOP complexes with additional ligase subunits and of disease mutants with altered structures. The implications of these structural changes will be characterized via in vitro biochemical and in cell functional assays.
Position Responsibilities:
The successful candidate will help shape the direction of the research and use will use cryo-EM and in vitro biophysical and biochemical studies to characterize SPOP structure and function. The candidate will interface with trainees and staff scientists in the Mittag lab and with collaborators in a highly collaborative, interdisciplinary environment that will support their career development.
Minimum Education and/or Training:
The successful candidate should have a Ph.D. in in vitro structural biology, protein biochemistry or biophysics. The candidate should demonstrate an academic record of excellence, and a strong interest in the growing field of biomolecular condensates. Experience with cryo-EM would be highly valuable to capitalize on the opportunities in this project.
About the lab and St. Jude:
The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates and ubiquitin ligase function in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in cryo-EM, NMR spectroscopy, X-ray crystallography, single molecule techniques, protein technology, and microscopy.
St. Jude Children's Research Hospital is a world-class research institution dedicated to pediatric cancer and other catastrophic diseases of childhood. The first and only National Cancer Institute (NCI)-designated Comprehensive Cancer Center devoted solely to children. Our 300 faculty work across the spectrum of basic, translational, clinical, and population science in a highly collaborative multidisciplinary environment that includes a Nobel laureate and members of the National Academy of Science and the National Academy of Medicine. St. Jude is ranked on Fortune Magazine's "Best Workplaces in Health Care & Biopharma" and Glassdoor's "Best Places to Work," and is located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food and culture.
We are in pursuit of the brightest minds in biomedical sciences, individuals poised to contribute to our research progress. Other than access to top-quality scientists and mentors, as a postdoctoral trainee at St. Jude, you will have:
  • A Blend of Academic Freedom and Industrial Efficiency: Access to shared resources and facilities led by expert scientists, coupled with cutting-edge technology, accelerates research productivity.
  • Customized Professional and Career Growth: Experience specifically designed programs to enhance professional growth and career readiness empowering postdocs for success beyond their training. This includes access to grant writing workshops, individual development plans, teaching and mentoring opportunities, non-research career advancement programs, professional development allowance, and so much more.
  • Competitive Compensation: Embark on your journey with a competitive salary starting at $72,500 a year, comprehensive benefits and generous relocation assistance, reflecting our commitment to recognize and invest in talent
  • A Sense of Community: St. Jude fosters a vibrant postdoc community that supports a well-balanced life. A dynamic environment promotes connections and camaraderie among postdocs from all backgrounds.

St. Jude is an Equal Opportunity Employer
No Search Firms
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

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