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Protein Structural Biology Jobs (NOW HIRING)

Nurix

Scientist II - Structural Biology

Brisbane, CA · On-site

Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and ... Serve as a structural biology resource across the research organization, providing mechanistic ...

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Protein Structural Biology information

What is protein structural biology?

Protein structural biology is a scientific field that focuses on understanding the three-dimensional structure of proteins at the molecular level. Researchers in this area use techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy to determine how proteins are shaped and how these shapes relate to their functions in the body. This knowledge helps us understand biological processes, develop new medicines, and design better enzymes for industrial use. Protein structural biology is essential for uncovering how proteins work and how changes in their structure can lead to diseases.

What is the difference between Protein Structural Biology vs Protein Biochemist?

AspectProtein Structural BiologyProtein Biochemist
Required CredentialsTypically PhD in Biochemistry, Structural Biology, or related fieldsUsually PhD or Master's in Biochemistry, Molecular Biology, or related fields
Work EnvironmentResearch labs, academic institutions, biotech companies focusing on structure determinationLaboratories, research institutions, industry settings focusing on protein function and interactions
Employer & Industry UsageAcademic research, pharmaceutical, biotech companiesPharmaceutical, biotech, research institutions

Protein Structural Biology focuses on determining the 3D structures of proteins using techniques like X-ray crystallography and cryo-EM, while Protein Biochemists study protein functions, interactions, and activities. Both roles require advanced degrees and often collaborate, but their primary goals differ: one emphasizes structure, the other function.

What are the key skills and qualifications needed to thrive as a Protein Structural Biologist, and why are they important?

To thrive as a Protein Structural Biologist, you need a strong background in molecular biology, biochemistry, and structural analysis techniques, typically supported by a Ph.D. or relevant research experience. Familiarity with technical tools such as X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, and molecular modeling software is essential. Critical thinking, attention to detail, and effective collaboration skills distinguish outstanding professionals in this field. These competencies enable accurate structure determination and interpretation, which are vital for advancing scientific understanding and drug discovery.

What are some typical challenges faced when working in a protein structural biology lab?

One common challenge in protein structural biology is obtaining high-quality, pure protein samples in sufficient quantities, as this step is critical for successful structural studies. Troubleshooting issues such as protein instability, aggregation, or low expression levels often requires iterative optimization and close collaboration with molecular biologists and biochemists. Additionally, interpreting complex structural data from techniques like X-ray crystallography or cryo-EM can be time-consuming and requires strong attention to detail. Despite these challenges, the collaborative and interdisciplinary nature of the work provides valuable learning opportunities and exposure to cutting-edge technologies.
Infographic showing various Protein Structural Biology job openings in the United States as of May 2026, with employment types broken down into 5% Internship, 74% Full Time, and 21% Contract. Highlights an 95% In-person, and 5% Remote job distribution.
Research Associate, Antibody & Protein Engineering

Research Associate, Antibody & Protein Engineering

Adimab

Lebanon, NH • On-site

Full-time

Medical, Retirement

Posted 18 days ago

Job description

Title: Research Associate, Antibody & Protein Engineering
Adimab is the leading technology provider for therapeutic antibody drug discovery, focusing solely on our partnerships without pursuing an internal product pipeline. Since 2009, we have partnered with over 140 pharmaceutical and biotechnology companies, generating more than 650 therapeutic programs, of which more than 85 have entered clinical trials.
Role Overview:
We are seeking a focused and enthusiastic protein engineer to join our Platform Technologies group. In this role, the Research Associate will work in a small, collaborative team to execute Adimab's platform for the discovery, optimization and characterization of protein-based therapeutics.
Responsibilities:
  • Designing and executing protein engineering experiments
  • Constructing yeast display libraries and performing FACS selections
  • Basic protein/DNA sequence and structural analysis
  • Basic yeast handling and propagation
  • Collecting, organizing, and analyzing antibody characterization data
  • Collaborating with colleagues and external partners
Needed Upon Hire:
  • B.S., or equivalent practical experience, with training in molecular biology, chemical engineering, or biochemistry
  • At least 2 years of lab experience in an academic or industry setting
  • Knowledge of molecular biology, protein engineering, structural biology, and/or flow cytometry
  • Meticulous approach to benchwork and data analysis
Value-added Experience:
  • Experience with protein display technologies (yeast, bacterial and/or ribosomal) desired
  • Knowledge of protein sequence analysis and next-generation sequencing workflows desired
  • Experience with protein structural analysis or computational design methods desired
  • Demonstrated ability to evaluate, interpret, and present scientific data
  • Internally motivated with proven track record of operating independently at the bench and bringing projects to completion
  • Excellent organization skills and the ability to manage multiple projects simultaneously
  • Adaptable and productive in a fast-paced environment
  • Communicates effectively and openly with colleagues and supervisors
  • Resourceful with outstanding execution and problem-solving skills
  • Excellent quantitative skills with a mastery of Excel

Come join us!
Our integrated antibody discovery and engineering platform provides unprecedented speed from antigen to purified, full-length human IgGs with exquisite specificity and biophysical behavior. We offer fundamental advantages by delivering diverse panels of antibodies that meet the most demanding standards for affinity, epitope specificity, species cross-reactivity, and developability. We enable our partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.
As a profitable privately-held biotech company, we take a long-term view on value creation and make substantial investments in technology development, research, and our people. We offer individually tailored compensation packages comprised of a competitive salary, meaningful equity, a 2:1 401(k) match, and comprehensive health care benefits.
Located in New Hampshire's beautiful Upper Connecticut River Valley, we are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated in an area that is renowned for its premier skiing, hiking, kayaking, and biking.

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