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Associate Scientist, Protein Sciences

San Jose, CA · On-site

$115K - $125K/yr

OBT is seeking an experienced, creative and motivated associate scientist to contribute to our company's Discovery Biologics Protein Science group. Work independently, and in a matrix, to lead the ...

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Protein Scientist information

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$28.5K

$90.8K

$149.5K

How much do protein scientist jobs pay per year?

As of Sep 13, 2026, the average yearly pay for protein scientist in the United States is $90,793.00, according to ZipRecruiter salary data. Most workers in this role earn between $66,000.00 and $114,500.00 per year, depending on experience, location, and employer.

What does a protein scientist do?

A Protein Scientist studies the structure, function, and properties of proteins to understand their roles in biological systems. They use techniques such as chromatography, mass spectrometry, and X-ray crystallography to analyze and modify proteins for applications in biotechnology, pharmaceuticals, and healthcare. Their work is critical in drug development, enzyme engineering, and disease research, contributing to advancements in medicine and industry.

What does a typical day look like for a protein scientist?

A typical day for a Protein Scientist often involves designing and conducting experiments to express, purify, and characterize proteins, as well as analyzing data using specialized software tools. You may spend time preparing samples, running laboratory equipment, and collaborating closely with team members across research and development, quality control, or bioprocessing departments. Documentation, presenting findings in meetings, and troubleshooting technical challenges are integral parts of the role. This dynamic environment offers the chance to contribute to novel discoveries and translates scientific breakthroughs into real-world applications.

What are the key skills and qualifications needed to thrive as a protein scientist?

To thrive as a Protein Scientist, you need a solid background in biochemistry, molecular biology, and protein expression and purification, typically supported by a relevant advanced degree such as a master's or Ph.D. Proficiency in laboratory techniques like chromatography, mass spectrometry, and familiarity with analytical software and LIMS (Laboratory Information Management Systems) is crucial. Strong problem-solving skills, meticulous attention to detail, and effective communication set outstanding candidates apart. Mastering both technical and soft skills ensures successful research outcomes, efficient teamwork, and innovation in this rapidly evolving scientific field.

How much do protein scientists make?

Protein scientists typically earn a median annual salary of around $70,000 to $100,000, depending on experience, education, and location. Senior roles or those with advanced degrees and specialized skills can earn higher salaries, often exceeding $120,000 annually.

What are some protein scientist jobs available?

Protein scientist jobs typically involve research and development in biotechnology, pharmaceuticals, or academic settings, focusing on protein structure, function, and interactions. These roles often require expertise in molecular biology, biochemistry, and laboratory techniques such as protein purification and analysis, with positions available in research institutions, biotech companies, and pharmaceutical firms.
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What states have the most Protein Scientist jobs?

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Protein Scientist jobs near you
Infographic showing various Protein Scientist job openings in the United States as of September 2026, with employment types broken down into 4% Internship, 2% As Needed, 87% Full Time, 4% Part Time, and 3% Contract. Highlights an 85% Physical, 2% Hybrid, and 13% Remote job distribution, with an average salary of $90,793 per year, or $43.7 per hour.

Principal / Senior Principal Scientist, Small Molecule Therapeutics

Cambridge, MA • On-site

Lila Sciences
See more jobs at Lila Sciencesexternal

Full-time

Medical, Dental, Vision, Life

Re-posted 23 days ago

Job description

Your Impact at LILA
We are seeking a Senior Principal Scientist, Small Molecule Therapeutics to lead the protein science and structural biology strategy supporting small molecule therapeutics across Lila's discovery platform. This individual will oversee recombinant protein construct design and engineering, expression and purification, and structural biology workflows that enable screening, hit validation, and structure-guided drug design. Working closely with Lila's screening, assay development, and chemistry teams, this role will help define, build, and scale internal capabilities for protein expression, purification, and structural enablement. The ideal candidate is a highly experienced protein scientist and drug discovery leader who can operate strategically while remaining deeply engaged in experimental design, vendor selection, data interpretation, and cross-functional program execution.
What You'll Be Building
  • Lead the protein science strategy for small molecule programs, ensuring timely delivery of high-quality protein reagents for screening, assay development, biophysics, crystallography, Cryo-EM, and downstream validation.
  • Oversee recombinant protein expression and purification efforts across external partners and CROs, including vendor selection, scope definition, protocol review, troubleshooting, quality assessment, and timeline management.
  • Develop and execute a roadmap to bring recombinant protein expression and purification capabilities in-house over time, including recommendations on infrastructure, workflows, staffing, instrumentation, and quality standards.
  • Lead construct design and protein engineering efforts to enable soluble, stable, active, and structurally tractable protein reagents across diverse target classes.
  • Design construct strategies including domain boundaries, truncations, tags, mutations, fusion partners, stabilizing variants, ortholog selection, and expression system selection.
  • Partner with assay biology, screening, chemistry, computational chemistry, and translational teams to ensure protein reagents are fit-for-purpose for biochemical, biophysical, cellular, and structural applications.
  • Lead outsourced X-ray crystallography activities, including construct and ligand complex strategy, crystallization campaign design, CRO management, structure review, and integration of structural insights into medicinal chemistry.
  • Manage external Cryo-EM activities where appropriate, including feasibility assessment, sample preparation strategy, vendor coordination, and interpretation of structural results.
  • Establish quality-control expectations for protein reagents, including purity, identity, activity, stability, aggregation state, binding competence, post-translational modifications, and lot-to-lot consistency.
  • Troubleshoot protein production, purification, stability, and structural biology challenges in collaboration with internal teams and external partners.
  • Build scalable processes for managing external protein science and structural biology work, including statements of work, decision criteria, data packages, documentation, and knowledge transfer.
  • Serve as a subject-matter expert in protein expression, purification, construct engineering, X-ray crystallography, and structural biology across the small molecule therapeutics portfolio.
  • Contribute to target assessment and program strategy by evaluating protein tractability, reagent feasibility, structural enablement, and risk mitigation plans.
  • Mentor and develop future team members as internal protein science capabilities expand.
  • Maintain awareness of emerging technologies, vendors, platforms, and best practices in recombinant protein production, structural biology, and structure-enabled drug discovery.

What You'll Need to Succeed
  • PhD in biochemistry, structural biology, molecular biology, protein engineering, or a related discipline, with 10+ years of relevant drug discovery experience; or an MS/BS with 15+ years of industry experience focused on protein chemistry and structural biology.
  • Deep expertise in recombinant protein expression and purification across multiple expression systems, such as bacterial, insect, and mammalian systems.
  • Demonstrated experience designing and engineering protein constructs for biochemical assays, biophysical characterization, crystallography, and/or Cryo-EM.
  • Strong track record supporting small molecule drug discovery programs through high-quality protein reagents and structural biology.
  • Hands-on and strategic experience with protein purification workflows, including affinity, ion exchange, size-exclusion, analytical characterization, and stability optimization.
  • Experience managing external CROs or partners for protein production, purification, crystallography, or related structural biology activities.
  • Strong understanding of X-ray crystallography workflows, including construct design, protein-ligand complex preparation, crystallization, data collection, structure determination, and structure interpretation.
  • Ability to assess protein reagent quality and suitability using analytical and biophysical methods such as SDS-PAGE, LC-MS, SEC, SEC-MALS, DSF, DLS, SPR, ITC, MST, enzyme activity assays, or related approaches.
  • Experience working cross-functionally with biology, chemistry, computational, screening, and program leadership teams.
  • Demonstrated ability to define strategy, manage timelines, troubleshoot complex technical problems, and communicate recommendations clearly to scientific and non-scientific stakeholders.
  • Strong scientific judgment and ability to balance speed, rigor, cost, and risk in a fast-moving discovery environment.

Bonus Points For
  • Experience building or scaling internal protein science capabilities, including lab design, platform selection, instrumentation recommendations, hiring plans, workflow development, and operational standards.
  • Experience with challenging drug discovery target classes, such as membrane proteins, multiprotein complexes, intrinsically disordered proteins, protein-protein interaction targets, kinases, GPCRs, and ion channels.
  • Familiarity with Cryo-EM sample preparation, vendor management, data interpretation, and feasibility assessment.
  • Experience integrating X-ray crystallography, Cryo-EM, computational modeling, and biophysical data into structure-guided medicinal chemistry.
  • Knowledge of protein stabilization approaches, including mutagenesis, ortholog screening, consensus design, thermostabilizing mutations, fusion partners, antibody/nanobody-assisted crystallography, and ligand stabilization.
  • Experience with biochemical and biophysical screening strategies such as DNA-encoded library screening, high-throughput screening, fragment-based screening, and structure-enabled hit validation.
  • Familiarity with AI/ML-enabled protein design, structure prediction, construct optimization, or computational chemistry workflows.
  • Experience with automation or high-throughput workflows for cloning, expression screening, purification, or protein characterization.
  • Excellent written and verbal communication skills, including experience reviewing technical reports, vendor proposals, structural data, and program-facing recommendations.

Compensation
We offer competitive base compensation with bonus potential and generous early-stage equity. Your final offer will reflect your background, expertise, and expected impact.
U.S. Benefits. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.
International Benefits. Full-time employees outside the U.S. receive a comprehensive benefits program tailored to their region. USD salary ranges apply only to U.S.-based positions; international salaries are set to local market.
Expected Base Salary Range
$156,000-$246,000 USD
About LILA
Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves.
LILA combines advanced AI models with proprietary AI Science Factory™ instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy. Learn more at www.lila.ai.
Guided by our core values of truth, trust, curiosity, grit, and velocity, we move with startup speed while tackling problems of historic importance. If this sounds like an environment you'd love to work in, even if you don't meet every qualification listed above, we encourage you to apply.
We're All In
Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Information you provide during your application process will be handled in accordance with our Candidate Privacy Policy.
A Note to Agencies
Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.

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