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$28.5K

$90.8K

$149.5K

How much do protein scientist jobs pay per year?

As of Jul 13, 2026, the average yearly pay for protein scientist in the United States is $90,793.00, according to ZipRecruiter salary data. Most workers in this role earn between $66,000.00 and $114,500.00 per year, depending on experience, location, and employer.

What does a typical day look like for a Protein Scientist?

A typical day for a Protein Scientist often involves designing and conducting experiments to express, purify, and characterize proteins, as well as analyzing data using specialized software tools. You may spend time preparing samples, running laboratory equipment, and collaborating closely with team members across research and development, quality control, or bioprocessing departments. Documentation, presenting findings in meetings, and troubleshooting technical challenges are integral parts of the role. This dynamic environment offers the chance to contribute to novel discoveries and translates scientific breakthroughs into real-world applications.

What are the key skills and qualifications needed to thrive in the Protein Scientist position, and why are they important?

To thrive as a Protein Scientist, you need a solid background in biochemistry, molecular biology, and protein expression and purification, typically supported by a relevant advanced degree such as a master's or Ph.D. Proficiency in laboratory techniques like chromatography, mass spectrometry, and familiarity with analytical software and LIMS (Laboratory Information Management Systems) is crucial. Strong problem-solving skills, meticulous attention to detail, and effective communication set outstanding candidates apart. Mastering both technical and soft skills ensures successful research outcomes, efficient teamwork, and innovation in this rapidly evolving scientific field.

What does a Protein Scientist do?

A Protein Scientist studies the structure, function, and properties of proteins to understand their roles in biological systems. They use techniques such as chromatography, mass spectrometry, and X-ray crystallography to analyze and modify proteins for applications in biotechnology, pharmaceuticals, and healthcare. Their work is critical in drug development, enzyme engineering, and disease research, contributing to advancements in medicine and industry.

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Protein Scientist jobs near you
Infographic showing various Protein Scientist job openings in the United States as of July 2026, with employment types broken down into 82% Full Time, 16% Part Time, 1% Contract, and 1% Nights. Highlights an 90% Physical, 1% Hybrid, and 9% Remote job distribution, with an average salary of $90,793 per year, or $43.7 per hour.
Scientist-Principal Scientist, Protein Design & Structure

Scientist-Principal Scientist, Protein Design & Structure

Superluminal Medicines, Inc.

Boston, MA

Other

Re-posted 12 days ago

Job description

Position Summary

We are seeking a highly innovative and experienced Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering and production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs. This role involves hands-on laboratory work and scientific leadership. 

Key Responsibilities

  • Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression.
  • Expression & Purification: Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
  • Cross-Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization.
  • Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies.
  • Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings.

Required Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience; or a master's or bachelor's degree in a related field with commensurate industry experience. 
  • Deep knowledge of GPCR biology and membrane protein structure-function relationships.
  • Proven expertise in molecular biology (cloning, construct design, mutagenesis).
  • Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC).
  • Familiarity with protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).
  • Excellent communication, interpersonal, and leadership skills.

Preferred Qualifications

  • Experience with structural biology methods (data collection and processing for Cryo-EM).
  • Experience in laboratory automation in protein sciences & purification.
  • Background in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction).

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