Protein Design Jobs in Reading, MA (NOW HIRING)

Principal Scientist - Protein Formulation & Biophysical Characterization (High-Concentration Biologics)

is a hands-on, laboratory-focused, scientific leadership role within a biologics and vaccines formulation group (DPDD- PhRD) for a deeply technical scientist driving innovation in protein formulation and high-concentration biologics.

The role focuses on developing and implementing novel formulation strategies and platform approaches to enable high-dose, patient-centric biologic delivery, including subcutaneous administration.

The successful candidate will generate mechanistic insights and translate them into scalable solutions that enhance Pfizer's drug product capabilities.

The individual will serve as a technical subject matter expert, contributing across cross-functional teams and building external scientific presence through publications, presentations, and participation in industry collaborations and consortia.

Key Responsibilities

1) Formulation Science & Characterization

• Design and execute experimental studies to develop and optimize protein formulations across biologic modalities (e.g., mAbs, fusion proteins, bispecifics, antibody-drug conjugates, peptides, etc.) in liquid and lyophilized dosage forms.

• Apply biophysical and physicochemical characterization to assess and mitigate key risks (e.g., aggregation, viscosity, stability).

• Analyze data, generate clear insights, and communicate findings to scientific teams.

2) Innovation & Technology Development

• Develop and advance novel formulation strategies and enabling technologies for high-concentration biologics.

• Build scalable approaches such as experimental workflows, screening methods, and predictive tools that can be applied across programs.

• Collaborate with cross-functional teams to implement and integrate new technologies.

3) External Scientific Engagement

• Build collaborations with academic and industry partners to advance formulation science.

• Contribute to external scientific visibility through publications, conference presentations, and participation in industry consortia.

4) Cross-Functional Contribution

• Collaborate with the internal Device Center of Excellence to facilitate optimal device selection, serving as a liaison and technical subject matter expert on formulation matters.

• Provide formulation expertise to project teams and support key development decisions.

• Contribute scientific input to regulatory documentation as needed.

5) Technical Leadership

• Lead a cross-functional group focused on subcutaneous delivery of biologics. Align with key stakeholders and devise and implement strategies to advance the biologics portfolio.

• Lead focused technical initiatives or platform problems; prior experience with formal project leadership is preferred but not required.

Education & Experience

• PhD in Pharmaceutics, Pharmaceutical Sciences, Biophysical Sciences, Biochemistry, Chemistry, Biomedical or Chemical Engineering, or related disciplines with 3-5 years relevant experience in biologics formulation, biophysics, or drug product development (industry experience preferred)

• Demonstrated scientific output (e.g., publications and/or conference presentations) preferred

Must Have

• Strong background in protein formulation for parenteral biologics

• Direct hands-on experience with biophysical/analytical characterization techniques and data interpretation including proficiency with a broad suite of techniques (DLS, DSC, DSF, SEC-MALS, NTA, CD, FTIR, fluorescence spectroscopy, rheology); ability to design and interpret multi-technique characterization studies

• Familiarity with parenteral dosage forms and delivery considerations

• Ability to analyze complex data and communicate clear, actionable insights

Nice to Have

• Demonstrated expertise in protein design/engineering principles, structure-function relationship, identification of developability hot spots, and how molecular attributes influence formulation behavior.

• Deep understanding of challenges at elevated protein concentrations: viscosity, self-association, aggregation, LLPS, colloidal instability, opalescence; familiarity with interaction parameters (kD, B22)

• Knowledge of subcutaneous drug delivery fundamentals: injection volume/concentration constraints, tissue interactions, injectability, bioavailability considerations, container closure compatibility

Optional Technical Skills

• Experience with formulation of oligonucleotides, peptides, or other non-mAb modalities is a plus

• Experience with molecular modeling, molecular dynamics simulations, machine learning/AI approaches for formulation or protein behavior prediction, QSPR modeling

PHYSICAL/MENTAL REQUIREMENTS

• Job involves lab-work and requires strong ability to perform complex data analysis and data interpretation.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Some travel required as part of project support, conference attendance, consortia participation, etc.

Relocation support available
Work Location Assignment:On Premise

The annual base salary for this position ranges from $106,000.00 to $176,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Pfizer endeavors to makewww.pfizer.com/careersaccessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please emaildisabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available onPfizer Careers.

Research and Development