ZipRecruiter

Log In

1

Protein Design Jobs in Connecticut (NOW HIRING)

Cedent

Senior Scientist (Branford, CT)

Branford, CT · On-site

$90K - $123K/yr

Expertise in protein design, expression, purification, and biophysical characterization * Deep experience with bispecific or multispecific formats and familiarity with T cell engagers * Working ...

CEDENT

Senior Scientist (Branford, CT)

Branford, CT

$90K - $123K/yr

... protein engineer who thrives in the lab and wants your work to move swiftly toward patients, this role offers real opportunity, purpose, and scientific challenge. What You'll Work On Design and ...

CEDENT

Senior Scientist

Branford, CT

$90K - $123K/yr

Expertise in protein design, expression, purification, and biophysical characterization * Deep experience with bispecific or multispecific formats and familiarity with T cell engagers * Working ...

Pfizer, Inc.

Sr. Scientist, Primary Pharmacology

Groton, CT · On-site

$93K - $156K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Independently design, develop, and perform in vitro assays for diverse protein targets to drive lead identification, SAR, and mechanistic pharmacology using a combination of biochemical and cellular ...

Pfizer

Sr. Scientist, Primary Pharmacology

Groton, CT · On-site

$93K - $156K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Independently design, develop, and perform in vitro assays for diverse protein targets to drive lead identification, SAR, and mechanistic pharmacology using a combination of biochemical and cellular ...

Arvinas

  • Medical

  • Dental

  • Vision

  • Life

Building on its leadership in targeted protein degradation, Arvinas achieved a major milestone in ... Provides strategic oversight for the design, execution, and interpretation of preclinical ...

Arvinas

Vice President, Neuroscience

New Haven, CT · On-site

  • Medical

  • Dental

  • Vision

  • Life

Building on its leadership in targeted protein degradation, Arvinas achieved a major milestone in ... Provides strategic oversight for the design, execution, and interpretation of preclinical ...

Arvinas

Vice President, Neuroscience

New Haven, CT · On-site

  • Medical

  • Dental

  • Vision

  • Life

Building on its leadership in targeted protein degradation, Arvinas achieved a major milestone in ... Provides strategic oversight for the design, execution, and interpretation of preclinical ...

Arvinas

  • Medical

  • Dental

  • Vision

  • Life

... protein degraders, that are designed to harness the body's own natural protein disposal system to ... Design Phase I/II/III research trials targeting neurologic diseases, requiring expertise and ...

Varsity Tutors

Biochemistry Tutor

New Haven, CT · Remote

$18 - $40/hr

... protein purification strategies, and interpreting gel electrophoresis results. Emphasizes molecular-level reasoning and connects biochemistry to drug design, clinical diagnostics, and genetic disease ...

Varsity Tutors

Biochemistry Tutor

Bridgeport, CT · Remote

$18 - $40/hr

... protein purification strategies, and interpreting gel electrophoresis results. Emphasizes molecular-level reasoning and connects biochemistry to drug design, clinical diagnostics, and genetic disease ...

Varsity Tutors

Biochemistry Tutor

Hartford, CT · Remote

$18 - $40/hr

... protein purification strategies, and interpreting gel electrophoresis results. Emphasizes molecular-level reasoning and connects biochemistry to drug design, clinical diagnostics, and genetic disease ...

Varsity Tutors

Biochemistry Tutor

Stamford, CT · Remote

$18 - $40/hr

... protein purification strategies, and interpreting gel electrophoresis results. Emphasizes molecular-level reasoning and connects biochemistry to drug design, clinical diagnostics, and genetic disease ...

Varsity Tutors

Biochemistry Tutor

Norwalk, CT · Remote

$18 - $40/hr

... protein purification strategies, and interpreting gel electrophoresis results. Emphasizes molecular-level reasoning and connects biochemistry to drug design, clinical diagnostics, and genetic disease ...

next page

Showing results 1-20

All JobsProtein Design JobsProtein Design Jobs in Connecticut

Protein Design information

What is the difference between Protein Design vs Protein Engineering?

AspectProtein DesignProtein Engineering
Required CredentialsBiochemistry, Molecular Biology, BioinformaticsBiochemistry, Molecular Biology, Bioinformatics
Work EnvironmentResearch labs, biotech companies, academiaResearch labs, biotech companies, academia
Industry UsageDesigning novel proteins, drug development, synthetic biologyModifying existing proteins for improved function or stability

Protein Design focuses on creating new proteins with specific functions, often using computational methods. Protein Engineering involves modifying existing proteins to enhance or alter their properties. Both roles require similar skills and are used in research, biotech, and pharmaceutical industries, but their goals differ: one designs from scratch, the other optimizes existing proteins.

What are some typical challenges faced by professionals in protein design, and how are they addressed within a team setting?

Professionals in protein design often encounter challenges such as predicting accurate protein folding, ensuring stability, and achieving desired biological activity. These complexities are typically addressed through close collaboration with computational biologists, structural biologists, and experimental scientists. Teams frequently hold cross-functional meetings to troubleshoot issues, share findings, and iterate on design strategies based on laboratory results. This collaborative environment helps leverage diverse expertise and accelerates the development of novel proteins with desired functions.

What are the key skills and qualifications needed to thrive as a protein design scientist, and why are they important?

To thrive as a Protein Design Scientist, you need a strong background in molecular biology, biochemistry, and computational modeling, typically supported by an advanced degree in a relevant field. Proficiency with tools such as Rosetta, PyMOL, and molecular dynamics simulation software, as well as experience with protein expression and purification techniques, is essential. Analytical thinking, problem-solving, and effective communication are important soft skills to drive innovation and collaborate with interdisciplinary teams. These skills are crucial for designing functional proteins, troubleshooting experiments, and advancing research goals in biotechnology and pharmaceutical development.

What is protein design?

Protein design is the process of creating new proteins or modifying existing ones to have specific functions or properties. This can involve using computational tools, laboratory techniques, or a combination of both to predict and engineer amino acid sequences that will fold into desired three-dimensional structures. Protein design is used in various fields, including medicine, biotechnology, and research, to develop novel enzymes, therapeutics, or materials. The field requires a strong understanding of biology, chemistry, and computer science to achieve successful outcomes.

What are popular job titles related to Protein Design jobs in Connecticut?

For Protein Design jobs in Connecticut, the most frequently searched job titles are:

What job categories do people searching Protein Design jobs in Connecticut look for?

The top searched job categories for Protein Design jobs in Connecticut are:

What cities in Connecticut are hiring for Protein Design jobs?

Cities in Connecticut with the most Protein Design job openings:

Protein Design jobs near you
Infographic showing various Protein Design job openings in Connecticut as of August 2026, with employment types broken down into 83% Full Time, 7% Part Time, and 10% Contract. Highlights an 93% In-person, 2% Hybrid, and 5% Remote job distribution.

Principal Scientist - Antibody Discovery/Protein Design

EVOLVEIMMUNE THERAPEUTICS INC

Branford, CT • On-site

Full-time

PTO

Re-posted 8 days ago

Job description

Join a company where your science will directly shape the future of cancer immunotherapy

Who We Are

EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, entered clinical trials in late 2025. Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune’s team consists of ~50 FTEs in R&D, business development, people & culture, finance and operations. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston/New York City corridor.

We're hiring a Principal Scientist to join our Biotherapeutics group focused on designing and advancing first-in-class immune-engaging biologics. If you’re a protein engineer with expertise in computational protein design with experimental experience in protein discovery and optimization through antibody display technologies with an interest in advancing drug candidate toward first-in-patient evaluation, this role offers real opportunity, purpose, and scientific challenge.

What You’ll Work on

  • Design and optimize novel antibody-based multispecifics targeting domains using AI/ML-model-based de novo sequence discovery
  • Lead antibody engineering and antibody display-based screening from idea to experimental execution including screening, hit prioritization, and initial characterization.
  • Optimize developability in lead optimization through computational and biophysical insights
  • Expand company computational protein design tools and capabilities
  • Collaborate across functional teams to support candidate selection and preclinical development
  • Present findings in a clear, compelling way to multidisciplinary teams
  • Mentor junior scientists and help shape our growing discovery efforts


_______________________________________

What You Bring

  • PhD in biochemistry, computational biology, or structural biology, and postdoctoral fellowship in a related field with 5+ years of antibody and biotherapeutic engineering industry experience
  • Foundation in protein design and molecular modeling using AI/ML
  • Yeast or alternative antibody display technologies experience from design through screening
  • Expertise in bispecific or multispecific protein design, expression, purification, and biophysical characterization
  • Strong communication, data interpretation, and cross-functional collaboration skills


________________________________________

What You’ll Gain

  • A hands-on, high-impact role shaping the design of next-generation immunotherapies
  • Opportunity to see your work move rapidly from concept to clinic
  • A visible position within the Biotherapeutics team, contributing directly to platform and pipeline innovation
  • A chance to collaborate across disciplines and influence key program decisions
  • Professional growth through exposure to diverse scientific challenges and cross-functional projects
  • Optional mentorship opportunities and the ability to help shape a growing discovery organization
  • A mission-driven, fast-paced biotech environment that values bold thinking and scientific excellence
  • A supportive, open culture built on collaboration, trust, and shared purpose

________________________________________

Why You’ll Love Working Here

• Direct impact: Your science will influence platform design and shape next-generation clinical programs.

• Cutting-edge science: Help pioneer new approaches to T cell redirection in solid tumors.

• Personal growth: Gain exposure to every stage of early discovery in a collaborative biotech setting.

• Collaborative culture: Join a supportive, curious, and driven team aligned around scientific innovation and patient outcomes.

• Top-tier facilities: Work in a brand-new, purpose-built lab and office space near New Haven, CT.

• Mission with meaning: Join a company working to give more patients real hope in the fight against cancer.

________________________________________

Additional Info

• This is a full-time, onsite position based in Branford, CT

• EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered

• We offer competitive salary, benefits, equity, and paid time off

• We are an equal opportunity employer and value diverse perspectives in all aspects of our work

• Learn more about our science and our team at www.evolveimmune.com

________________________________________

Search Keywords

Antibody Engineering | Yeast/phage Display Technologies | AI/ML Protein Design tools | Bispecific Antibodies | Protein Engineering | Biotherapeutics | Biologics Development | T Cell Engager | Branford Biotech Jobs | Scientist Antibody Discovery | Immunotherapy Careers | Cancer Biotech | Molecular Biology | Biotech Scientist CT | New Haven Biotech | Oncology Drug Discovery | EvolveImmune Careers