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Principal Systems Engineer Jobs in Boston, MA (NOW HIRING)

Myomo, Inc

Principal Systems Engineer

Burlington, MA · On-site

$165K - $185K/yr

Principal Systems Engineer Department: Engineering Employment Type: Full Time Location: Burlington, MA Compensation: $165,000 - $185,000 / year Description Why should you join our success story?

New

Draper Inc.

Principal Systems Engineer

Cambridge, MA · On-site

$147 - $245/hr

The Digital Engineering and Enabling Technologies Division is seeking a Principal Systems Engineer to develop next generation requirements, model-based systems engineering concepts, and cross-domain ...

Inuplands

Principal Systems Engineer

Cambridge, MA · On-site

$95 - $245/hr

The Digital Engineering and Enabling Technologies Division is seeking a Principal Systems Engineer to develop next generation requirements, model-based systems engineering concepts, and cross-domain ...

Draper

Principal Systems Engineer

Cambridge, MA

$95K - $245K/yr

The Digital Engineering and Enabling Technologies Division is seeking a Principal Systems Engineer to develop next generation requirements, model-based systems engineering concepts, and cross-domain ...

Draper

Principal Systems Engineer

Cambridge, MA · On-site

$95K - $245K/yr

The Digital Engineering and Enabling Technologies Division is seeking a Principal Systems Engineer to develop next generation requirements, model-based systems engineering concepts, and cross-domain ...

Draper

Principal Systems Engineer

Cambridge, MA · On-site

$95K - $245K/yr

The Digital Engineering and Enabling Technologies Division is seeking a Principal Systems Engineer to develop next generation requirements, model-based systems engineering concepts, and cross-domain ...

Raytheon

Principal Systems Engineer

Tewksbury, MA

Raytheon is seeking a talented and motivated Principal Systems Engineer to join our team within the Systems Engineering and Test Capabilities (SETC) Discipline, supporting the LTAMDS and GhostEye ...

Draper

Principal Systems Engineer

Cambridge, MA · On-site

$95 - $245/hr

The Digital Engineering and Enabling Technologies Division is seeking a Principal Systems Engineer to develop next generation requirements, model-based systems engineering concepts, and cross-domain ...

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Showing results 1-20

All JobsPrincipal Systems Engineer JobsPrincipal Systems Engineer Jobs in Boston, MA

Principal Systems Engineer information

See Boston, MA salary details

$22.8K

$162.1K

$243.9K

How much do principal systems engineer jobs pay per year?

As of Aug 19, 2026, the average yearly pay for principal systems engineer in Boston, MA is $162,106.00, according to ZipRecruiter salary data. Most workers in this role earn between $130,400.00 and $190,100.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a principal systems engineer?

To thrive as a Principal Systems Engineer, you need deep expertise in systems architecture, integration, and engineering principles, typically backed by a degree in engineering or computer science. Familiarity with systems modeling tools (such as SysML), requirements management platforms, and relevant certifications like INCOSE CSEP are highly valued. Outstanding problem-solving, leadership, and communication skills distinguish top performers in this role. These skills are crucial for designing complex systems, guiding multidisciplinary teams, and delivering solutions that meet technical and business objectives.

How does a principal systems engineer typically collaborate with cross-functional teams during project development?

A Principal Systems Engineer plays a central role in coordinating between hardware, software, and project management teams to ensure system integration and project alignment. They often facilitate technical discussions, clarify requirements, and help resolve complex engineering challenges by leveraging their expertise. Regularly, they lead design reviews, mentor junior engineers, and act as the technical liaison between stakeholders to ensure project milestones are met. This collaborative approach helps maintain project quality and fosters innovation within the team.

What is the difference between Principal Systems Engineer vs Systems Engineer?

AspectPrincipal Systems EngineerSystems Engineer
Required CredentialsBachelor's or Master's in Engineering, often with certifications like PMP or INCOSEBachelor's degree in Engineering or related field
Work EnvironmentLead complex projects, oversee system integration, collaborate with cross-functional teamsSupport system development, perform testing, assist in system implementation
Employer & Industry UsageDefense, aerospace, large tech firms, government agenciesTechnology companies, manufacturing, defense contractors
Search & Comparison IntentUnderstanding senior technical roles, career progressionEntry to mid-level roles, job responsibilities

The Principal Systems Engineer typically holds a senior technical leadership role, overseeing complex projects and guiding teams, while the Systems Engineer focuses on supporting system development and implementation. Both roles require engineering credentials, but the Principal position involves more strategic oversight and experience.

What does a principal systems engineer do?

A principal systems engineer designs, develops, and oversees complex engineering systems, ensuring they meet technical requirements and performance standards. They often lead technical teams, coordinate system integration, and utilize tools like modeling software, with a focus on system architecture, reliability, and scalability.

What are popular job titles related to Principal Systems Engineer jobs in Boston, MA?

For Principal Systems Engineer jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Principal Systems Engineer jobs in Boston, MA look for?

The top searched job categories for Principal Systems Engineer jobs in Boston, MA are:

What cities near Boston, MA are hiring for Principal Systems Engineer jobs?

Cities near Boston, MA with the most Principal Systems Engineer job openings:

Principal Systems Engineer jobs near you
Infographic showing various Principal Systems Engineer job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 10% Part Time, 5% Contract, and 1% Nights. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $162,106 per year, or $77.9 per hour.

Principal Systems Engineer

Myomo, Inc

Burlington, MA • On-site

$165K - $185K/yr

Full-time

Posted yesterday

New

Job description

Principal Systems Engineer
Department: Engineering
Employment Type: Full Time
Location: Burlington, MA
Compensation: $165,000 - $185,000 / year
Description
Why should you join our success story?
Based on patented technology developed at MIT, Harvard Medical School and by the Company, Myomo develops and markets the MyoPro® product line of lightweight, non-invasive, powered arm braces (orthoses) to restore function in paralyzed or weakened arms and hands of individuals that have suffered a stroke, spinal cord, or nerve injury. (E.g. brachial plexus injury or other neuro-muscular disabilities.) It is the only device that, sensing a patient's own neurological signals through non-invasive wearable sensors, can restore the ability to use their arms and hands so that they can live independently, increase their quality of life, reduce cost of care, and return to work. Published clinical research shows a clinically significant instantaneous reduction in upper extremity impairment with the MyoPro. Our technology has been referred by leading-edge rehabilitation facilities including Mayo Clinic, Kennedy Krieger Institute, Cleveland Clinic, Loma Linda Medical Center, Massachusetts General Hospital, numerous VA Hospitals, and more. Myomo is headquartered in Burlington, Massachusetts, with sales and clinical professionals across the U.S.
What we're looking for:The Principal Systems Engineer leads system-level design and integration activities for Myomo's medical device product line. This role defines product architecture, ensures alignment between mechanical, electrical, and software components, and drives innovation aimed at enhancing performance, reliability, and safety. The Principal Systems Engineer provides technical leadership across cross-functional teams, ensuring that Myomo's products meet user needs, regulatory standards, and business goals.
How You'll Drive Impact:
  • Lead design, development, and integration of medical devices and mechatronic subsystems to meet customer and business needs.
  • Define and maintain system architecture across hardware, software, and user interfaces in collaboration with engineering and product management.
  • Translate customer and business requirements into functional, performance, and safety specifications.
  • Drive risk management and system-level verification and validation activities in accordance with medical device standards.
  • Develop prototypes, evaluating design concepts, driving innovative solutions in support of Myomo's intellectual property portfolio.
  • Ensure design intent and product reliability through cross-functional collaboration with Quality, Manufacturing, Clinical, and Customer support.
  • Apply requirements-driven design and systems engineering principles to manage trade-offs across cost, schedule, and performance.
  • Identify and mitigate technical and project risks, ensuring timely communication and resolution.
  • Promote continuous improvement in engineering processes, design practices, and documentation standards.
  • Mentor engineers across disciplines and fostering a collaborative, innovative engineering culture.

What You'll Bring:
  • Bachelor's or Master's degree in Biomedical, Mechanical, Electrical, or Systems Engineering.
  • 10-15 years of product development experience, including 5+ years in the medical device industry.
  • Proven track record of leading system design and integration for complex electromechanical products.
  • Prior experience defining architecture, requirements, and risk management in compliance with standards such as ISO 13485 and ISO 14971.
  • Strong background in innovation and intellectual property development (patent authorship preferred).
  • Knowledge of rapid-prototyping and manufacturing processes including 3D printing, CNC machining, and injection molding.
  • Familiarity with related engineering domains, including embedded software and electronics.
  • Demonstrated ability to manage multiple projects, prioritize effectively, and work independently with minimal supervision.
  • Excellent communication, collaboration, and problem-solving skills.
  • Attention to detail and strong organizational skills.

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