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Principal Statistical Programmer Jobs in Boston, MA

Vrtx

Principal Statistical Programmer

Boston, MA · Remote

$149K - $223K/yr

The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. In addition, the Principal ...

Prometrika LLC

Principal Biostatistician

Cambridge, MA · On-site

$178K - $216K/yr

Proficiency in SAS statistical programming * Knowledge of other statistical and data management software packages is a plus * Strong written and oral communication skills * Knowledge and experience ...

MIT Lincoln Laboratory

AL/ML Programmer

Lexington, MA · On-site

D. in electrical engineering, computer science, or another relevant discipline, or a Masters and 5 + years of relevant experience will be considered. Desired Skills * Knowledge of artificial ...

MIT Lincoln Laboratory

AL/ML Programmer

Lexington, MA · On-site

D. in electrical engineering, computer science, or another relevant discipline, or a Masters and 5 + years of relevant experience will be considered. Desired Skills * Knowledge of artificial ...

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All JobsPrincipal Statistical Programmer JobsPrincipal Statistical Programmer Jobs in Boston, MA

Principal Statistical Programmer information

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How much do principal statistical programmer jobs pay per hour?

As of Aug 11, 2026, the average hourly pay for principal statistical programmer in Boston, MA is $91.86, according to ZipRecruiter salary data. Most workers in this role earn between $79.13 and $106.01 per hour, depending on experience, location, and employer.

What is a principal statistical programmer?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the key skills and qualifications needed to thrive in the principal statistical programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

What are the typical daily responsibilities of a principal statistical programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.

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Principal Statistical Programmer jobs near you
Infographic showing various Principal Statistical Programmer job openings in Boston, MA as of August 2026, with employment types broken down into 87% Full Time, 10% Part Time, 1% Temporary, and 2% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $191,070 per year, or $91.9 per hour.

Principal Statistical Programmer, Biometrics

Agios Pharmaceuticals, Inc.

Cambridge, MA • On-site

Full-time

Re-posted 6 days ago

Job description

Principal Statistical Programmer, Biometrics
Who we are:
At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture - one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion - because our differences shape how we hire, collaborate, and innovate. Our team's proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific - it's deeply personal, grounded in the meaningful connections we have built. To learn more, visit www.agios.com and follow Agios on LinkedIn and X.
The impact you will make:
Agios Pharmaceuticals is seeking a dynamic Principal Statistical Programmer to join our growing Biometrics team. We are looking for someone who is passionate about this work and motivated by our mission to serve patient communities. In this role, you will lead study-level statistical programming deliverables, including developing programming specifications and programs for SDTMs and analysis datasets in accordance with Agios, CDISC, and study- or submission-specific standards; develop programs for tables, listings, and figures based on Agios standards or study-specific/submission-specific requirements, reviewing CRFs and creating SDTM-annotated CRFs; reviewing statistical analysis plans, analysis datasets, and outputs; performing hands-on programming; and reviewing CRO deliverables. Candidate must have a strong working knowledge of CDISC requirements and Pinnacle 21.
What you will do:
  • Develop and/or validate programming specifications and programs to generate SDTMs and analysis datasets, using Agios, CDISC standards and study-specific/submission-specific requirements.
  • Develop and/or validate specifications and programs to generate tables, listings, and figures based on Agios standards and study-specific/submission-specific requirements.
  • Create SDTM-annotated CRFs
  • Accountable for study-level statistical programming deliverables on assigned projects, including timeliness and quality of deliverables.
  • Review statistical analyses plans and case report forms.
  • Ensure documentation is maintained to the standard required according to CDISC-compliant submissions and is acceptable for audit.
  • Support establishment and maintenance of statistical programming standards at Agios.
  • Ensure that all study-level statistical programming activities are conducted in compliance with relevant regulatory requirements, Agios SOPs and Agios standards.
  • Serve as a general statistical programming resource at Agios including representation in cross-functional teams working on standard operating procedures, guidelines, process improvements, system validation and acquisition, customization, and integration of new tools and technologies.

What you bring:
  • MS or equivalent degree with 7+ years biopharmaceutical industry experience
  • 3+ years project management experience as a statistical programmer preferred
  • Advanced knowledge of SAS/Base, SAS/Macro, SAS/STAT, SAS/Graph, and SAS/SQL in a windows environment
  • Extensive experience and proven skills in the use of SAS within a Statistical Programming environment to develop and validate analysis datasets, tables, listings, and figures
  • Hands-on experience on SDTM mapping from various data sources
  • Knowledge of clinical database design, specifically electronic data capture using Rave, Veeva, and Medidata
  • Experience supporting electronic submissions in the eCTD format
  • Excellent oral and written communication skills
  • Experience in open-source languages like Python or R preferred

Concerned that you don't check off every box in the requirements listed above? Please apply anyway! At Agios, we value each other's differences and recognize that teams thrive when everyone brings their unique experiences to the table. We are dedicated to building an inclusive, diverse, equitable, and accessible environment where all employees can bring their whole selves to work. If you're excited about this role but your previous experience doesn't align perfectly with the job description, we still encourage you to apply. You may be just the right candidate for this role or another opening!
Work Location:
Location Agnostic: Work location for this role is based on employee's individual preference. This role has the ability to be either remote in the US or hybrid in our Cambridge Headquarters. Hybrid schedules vary but are generally less than 3 days per week onsite and hybrid employees are expected to live within commutable distance to our Cambridge Headquarters. Remote employees work entirely from home except for attending Company sponsored events/ meetings. For employees who choose to work remotely, travel may be required for certain company events commensurate to the above job description.
What we will give you:
  • Deliberate Development. Your professional growth as one of our top priorities.
  • Flexibility. We're all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you're at your best, we're at our best.
  • Premium benefits package. We invest in the health, wellbeing, and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team. For more detail on the benefits we offer at Agios, visit the Inside Agios section of our website.
  • Competitive and equitable performance-based compensation. This includes base salary and both short- and long-term incentives that are connected to our business strategy and vary based on individual and company performance.
    • The current base salary range for this Senior Manager position is expected to be between $131,035 and $196,553 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators.
  • Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries.
  • Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We're continuously looking to improve the inclusivity of our workforce.
  • Commitment to community. We're an active participant in the communities that surround us - the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked.

Interested in learning more about what makes our culture unique? Visit the Inside Agios section of our website.

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