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Principal Process Engineer Implant Jobs (NOW HIRING)

AstraZeneca

Principal Process Engineer

Mount Vernon, IN · On-site

Key Accountabilities The role of the Principal Process Engineer has the following responsibilities: * Serve as skill area leader for pharmaceutical unit operations with a focus on the mechanistic ...

New

ASM

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Phoenix, AZ · On-site

As a Principal Process Engineer at ASM, you will work with semiconductor processing and analytical equipment to research, develop and optimize processes focused on oxidation, annealing, curing ...

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A Day in the Life Our CardioVascular Surgery Operating Unit (OU) is looking for a Principal Process Engineer. The role will specialize in the optimization of dip molding processes and polymer ...

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Principal Process Engineer

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A Day in the Life Our CardioVascular Surgery Operating Unit (OU) is looking for a Principal Process Engineer. The role will specialize in the optimization of dip molding processes and polymer ...

Nokia

Principal Process Engineer

Allentown, PA · On-site

$125K - $232K/yr

The Principal Process D e vel o p m e n t E n g i n eer is responsible for developing new and/or ... He or she must be a multitasking team player and able to interface with multiple engineering groups.

Nokia

Principal Process Engineer

Allentown, PA · On-site

The Principal Process D e vel o p m e n t E n g i n eer is responsible for developing new and/or ... He or she must be a multitasking team player and able to interface with multiple engineering groups.

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As of Sep 13, 2026, the average yearly pay for principal process engineer implant in the United States is $150,082.00, according to ZipRecruiter salary data. Most workers in this role earn between $130,000.00 and $169,500.00 per year, depending on experience, location, and employer.

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Principal Process Engineer

Mount Vernon, IN • On-site

AstraZeneca
Pharmaceutical Product Wholesalers • 10K+ employees
Learn more about AstraZenecaexternal

Full-time

Posted 3 days ago

New

AstraZeneca rating

8.4

Company rating: 8.4 out of 10

Based on 45 frontline employees who took The Breakroom Quiz

Job description

Key Accountabilities
The role of the Principal Process Engineer has the following responsibilities:
  • Serve as skill area leader for pharmaceutical unit operations with a focus on the mechanistic understanding of process-equipment interface.
  • Lead of technical strategic initiatives, networks or forums within the organization related to pharmaceutical manufacturing processes and equipment.
  • Executing Technical Leadership and influencing across Operations.
  • Apply process engineering principles to identify opportunities for, develop and deploy reduced-order mechanistic and physics-informed process models based on first-principles engineering and equipment geometry (e.g. mass, energy and momentum balances) to predict process performance, resolve operational issues, support scale-up and optimise equipment and system integration.
  • Provide technical leadership and expertise in resolving complex manufacturing challenges through the application of first-principles engineering analysis, mechanistic modelling and simulation, developing fit-for-purpose reduced-order models to identify root causes, assess risks and improve process performance.
  • Contribute to product supply strategy projects, including sourcing, asset transfers, capacity expansions, and the introduction of new equipment.
  • Lead technical support for the transfer of established product manufacturing processes within internal manufacturing sites and to external partners, employing scale-up modelling, equipment selection, and comprehensive manufacturing engineering support.
  • Identify opportunities for manufacturing improvement, lead impact assessments, and support the implementation of technical improvements or major change initiatives with a focus on maintaining product performance, including contributions to regulatory file authoring, license renewals, and responses to regulatory queries, supported by model-based risk assessments.
  • Drive the standardisation and modernisation of manufacturing equipment and processes across Operations, leveraging advanced modelling and simulation to meet regulatory requirements, support good business practices, and ensure manufacturability and quality standards.

Required Skills & Knowledge
  • Demonstrate an understanding of the overall drug development and commercialization process from development, launch, and through life cycle management.
  • Process/chemical Engineering BSc/MSc with 7+ years of relevant pharmaceutical industry experience post degree or PhD level with 5+ years of experience post degree
  • Demonstrate an understanding of pharmaceutical product End-to-End Control Strategy (CS) and/or Enhanced Control Strategy (ECS).
  • Have demonstrated experience in the development and application of reduced-order mechanistic and physics-informed models of pharmaceutical unit operations and equipment (e.g. mixing, drying, compression, roller compaction, continuous direct compression and coating), including models derived from equipment geometry and first-principles engineering relationships such as mass and energy balances.
  • Demonstrate an understanding of physical characterisation of raw material, intermediate and final products and impact on manufacturing process robustness (e.g. mechanical testing, PSD, imaging etc).
  • Have experience in scientific programming, data analysis and digital tools used to develop, implement and maintain mechanistic and hybrid (physics-informed) process models.
  • Have experience with a range of CMC elements related to commercial product manufacturing process requirements - e.g., process establishment, optimisation and validation, control of drug products, stability, packaging and commercial manufacturing, with good understanding of SHE and cGMP.
  • Experience in Pharmaceutical Operations and/or R&D with a track record of successful project leadership and delivery within a matrix organisation.
  • Evidence of good communication and leadership skills.

Preferred Skills & Knowledge
  • Experience in or exposure to multiple disciplines in CMC and related functions (e.g. Product Development, Operations, Global Supply, Marketing Companies)
  • Have previous experience and training in Lean and Six Sigma, problem solving tools, Agile application.
  • Have experience in physical testing techniques of raw materials, intermediate and final drug products.
  • Experience in or exposure to coding and programming languages.

Date Posted
11-Sep-2026
Closing Date
01-Oct-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

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About AstraZeneca

Sourced by ZipRecruiter

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. A place built on courage, curiosity and collaboration - we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team. Make a meaningful impact that brings real benefits to society. By applying your knowledge of data, you will help to redefine our industry and ultimately save lives. Work with experts who share a common goal: to accelerate the potential of medicines and the science of tomorrow.

Industry

Pharmaceutical product wholesalers and pharmaceutical and medicine manufacturing

Company size

10,000+ Employees

Headquarters location

Cambridge, Cambridgeshire, GB

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