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Principal Data Engineer Jobs in Washington (NOW HIRING)

BullFrogAI

Principal Data Scientist

Gaithersburg, MD · On-site

$175K - $215K/yr

BullFrog AI is seeking an exceptional Principal Data Scientist with a strong background in ... Strong foundation in data engineering and databases * Experience with graph-based approaches ...

Capital One

Principal Data Analyst - Card

Mclean, VA · On-site

Principal Data Analyst - Card At Capital One, data is at the center of everything we do. When we ... Degree specialized in a Science, Technology, Engineering, Mathematics discipline * Scripting ...

Markon

Principal Data Scientist

Annapolis Junction, MD

$150K - $210K/yr

PLEX Solutions, A Part of Markon, is looking for a Principal Data Scientist to support a contract ... Collaborate with AI/ML engineers and data scientists to understand data requirements and optimize ...

Markon

Principal Data Scientist

Annapolis Junction, MD · On-site

$150K - $210K/yr

Description PLEX Solutions, A Part of Markon, is looking for a Principal Data Scientist to support ... Collaborate with AI/ML engineers and data scientists to understand data requirements and optimize ...

Capital One

Principal Data Analyst - Card

Mclean, VA · Hybrid

Principal Data Analyst - Card At Capital One, data is at the center of everything we do. When we ... Degree specialized in a Science, Technology, Engineering, Mathematics discipline * Scripting ...

Capital One

Principal Data Analyst - Card

Mclean, VA · On-site

Principal Data Analyst - Card At Capital One, data is at the center of everything we do. When we ... Degree specialized in a Science, Technology, Engineering, Mathematics discipline * Scripting ...

Markon

Principal Data Scientist

Annapolis Junction, MD · On-site

$150K - $210K/yr

Description PLEX Solutions, A Part of Markon, is looking for a Principal Data Scientist to support ... Collaborate with AI/ML engineers and data scientists to understand data requirements and optimize ...

Themis Insight

Principal Software/Data Engineer

Laurel, MD · On-site

$133K - $179K/yr

We are hiring a Principal Software/Data Engineer to work in Laurel, MD . Position location is subject to change based on central MD client's needs. Required: TS/SCI with a Polygraph As a Principal ...

Themis Insight

Principal Software/Data Engineer

Laurel, MD

$133K - $179K/yr

We are hiring a Principal Software/Data Engineer to work in Laurel, MD . Position location is subject to change based on central MD client's needs. Required: TS/SCI with a Polygraph As a Principal ...

Themis Insight

Principal Software/Data Engineer

Laurel, MD · On-site

$133K - $179K/yr

We are hiring a Principal Software/Data Engineer to work in Laurel, MD . Position location is subject to change based on central MD client's needs. Required: TS/SCI with a Polygraph As a Principal ...

Power3 Solutions

Principal Software/Data Engineer

Laurel, MD · On-site

$133K - $179K/yr

We are hiring a Principal Software/Data Engineer to work in Laurel, MD . Position location is subject to change based on central MD client's needs. Required: TS/SCI with a Polygraph As a Principal ...

Power3 Solutions

Principal Software/Data Engineer

Laurel, MD · On-site

$133K - $179K/yr

We are hiring a Principal Software/Data Engineer to work in Laurel, MD . Position location is subject to change based on central MD client's needs. Required: TS/SCI with a Polygraph As a Principal ...

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Showing results 21-40

All JobsPrincipal Data Engineer JobsPrincipal Data Engineer Jobs in Washington

Principal Data Engineer information

See Washington salary details

$83.8K

$166.7K

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How much do principal data engineer jobs pay per year?

As of Aug 15, 2026, the average yearly pay for principal data engineer in Washington is $166,741.00, according to ZipRecruiter salary data. Most workers in this role earn between $134,200.00 and $195,900.00 per year, depending on experience, location, and employer.

What are the typical daily responsibilities of a principal data engineer?

As a Principal Data Engineer, your day-to-day responsibilities generally include designing and optimizing large-scale data pipelines, developing architectural strategies, and overseeing the implementation of robust data solutions. You'll collaborate closely with data scientists, analysts, and software engineers to ensure the organization's data infrastructure is efficient, scalable, and secure. You may also mentor junior team members, review code, and set data engineering best practices. This role frequently requires balancing hands-on technical work with strategic planning and stakeholder communication to align data initiatives with business goals.

What is a principal data engineer?

A Principal Data Engineer is a senior-level technical role responsible for designing, building, and maintaining large-scale data infrastructure. They lead data engineering teams, establish best practices, and ensure efficient data pipelines to support analytics and machine learning. This role involves working with cloud platforms, big data technologies, and distributed systems to optimize data processing. Principal Data Engineers collaborate with data scientists, analysts, and business stakeholders to drive data-driven decision-making. Their work is critical in enabling organizations to leverage data effectively for insights and innovation.

What are the key skills and qualifications needed to thrive as a principal data engineer?

To thrive as a Principal Data Engineer, you need a deep understanding of data architecture, data modeling, ETL development, and distributed computing, often supported by a degree in computer science or a related field. Proficiency with technologies such as Hadoop, Spark, Python, SQL, and cloud platforms (AWS, Azure, or Google Cloud), as well as certifications in relevant tools or data engineering, is highly valuable. Strong leadership, problem-solving skills, and effective cross-functional communication are essential soft skills for this role. These combined abilities enable Principal Data Engineers to design scalable data solutions, drive engineering best practices, and lead complex projects to successful completion.

What are the most commonly searched types of Principal Data Engineer jobs in Washington?

The most popular types of Principal Data Engineer jobs in Washington are:

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For Principal Data Engineer jobs in Washington, the most frequently searched job titles are:

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Principal Data Engineer jobs near you
Infographic showing various Principal Data Engineer job openings in Washington as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $166,741 per year, or $80.2 per hour.

Principal Data Scientist

BULLFROG AI MANAGEMENT LLC

Gaithersburg, MD • On-site, Remote

$175K - $215K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 6 days ago

Job description

Description

About BullFrog AI

BullFrog AI (NASDAQ: BFRG) is a computational biology company spun out of the Johns Hopkins Applied Physics Laboratory. We sit at the intersection of AI and drug discovery, building platforms that help pharmaceutical and biotech companies make better, faster decisions across the drug development lifecycle:

  • bfPREP - biology-aware data harmonization that unlocks the value trapped in fragmented, multi-site clinical and omics datasets
  • bfLEAP - causal AI analytics for patient subgroup discovery, biomarker identification, and drug target prioritization
  • bfARENAS - structured multi-criteria decision support for high-stakes portfolio, indication, and go/no-go decisions


The Role

Help turn complex biomedical and clinical data into defensible decisions for drug discovery and development.


BullFrog AI is seeking an exceptional Principal Data Scientist with a strong background in biomedical analytics. This is a senior individual contributor role that combines client-facing project leadership with direct contributions to BullFrog's in-house platform - spanning target discovery, patient subtyping, and multimodal data analysis.


Day-to-day work is client-dependent, with each engagement bringing a different analytical challenge. You will be expected to lead from execution and bring scientific rigor, technical depth, and clear communication to every project.



What You'll Do


Client Engagement & Project Leadership

  • Own end-to-end analytical workstreams across target discovery, patient subtyping, and multimodal data exploration
  • Translate complex data science findings into clear, actionable insights for non-technical stakeholders and senior leadership
  • Collaborate effectively with distributed, remote teams to ensure seamless communication and on-time delivery


Technical Delivery

  • Design, implement, and optimize AI/ML models using diverse healthcare data types, including omics, claims, and EHR
  • Conduct multi-omic analyses such as RNA-seq differential expression, clustering, genomic association analysis, and biomarker discovery
  • Implement NLP and LLM solutions tailored to life sciences datasets
  • Contribute to the development and refinement of BullFrog's in-house platform capabilities

Requirements

What We're Looking For


Education

Advanced degree (MS or PhD) in a quantitative field - biology, computer science, engineering, or related


Experience

5+ years of post-graduate experience in life sciences analytics in pharma, biotech, or consulting

Demonstrated proficiency in Python; production-quality code in a research or commercial environment

Hands-on experience with major healthcare data types - omics data required; claims and EHR experience strongly preferred

Hands-on experience applying LLMs or NLP to real analytical workflows, ideally biomedical or clinical text extraction, summarization, evaluation, or retrieval

Proven track record of collaborating effectively with remote teams

Must be legally authorized to work in the United States


Desired Skills

Prior experience in multi-modal analysis with deep learning

Causal inference experience - a significant differentiator for this role

NLP/LLM expertise applied to life sciences and healthcare text

Strong foundation in data engineering and databases

Experience with graph-based approaches: feature engineering, ML, and visualization

Cloud platform experience, particularly AWS or Google Cloud


Who Will Thrive Here

Intellectually versatile - energized by moving across problem types, data modalities, and scientific domains

Client-ready - comfortable presenting to and partnering with senior scientific and business stakeholders

Independently driven - able to scope, execute, and deliver complex analyses without heavy oversight

Scientifically rigorous - you hold your work to a publication-quality standard even in a commercial environment

Collaborative by default - remote-first is second nature; you communicate proactively and close loops


What We Offer

Base salary range: $175,000 - $210,000 per year, based on level of education, years of relevant experience, skills, and location. This role is eligible for performance bonus and equity/stock options, subject to company and plan terms. Benefits include medical, dental, and vision from day one, short-term disability, 401(k) from first paycheck, 15 days PTO, 11 paid holidays annually, and maternity and paternity leave. 
BullFrog AI is an equal opportunity employer. We are committed to building a diverse team that reflects the communities and patients our work ultimately serves. 
Advancing medicine through artificial intelligence.

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