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Principal Clinical Research Associate Jobs (NOW HIRING)

North American Science Associates, Inc.

$100 - $125/hr

Certifications such as Society of Clinical Research Associates (SoCRA) or Association of Clinical ... NAMSA was founded on the principals of delivering quality customer service, conducting ourselves ...

Icon plc

About the Opportunity As a Clinical Research Associate within our sponsor-dedicated environment, you will play a critical role in the successful delivery of clinical trials, helping bring innovative ...

Tigermed America

Clinical Research Associate

Denver, CO · On-site

Senior Clinical Research Associate As Clinical Research Associate you will be responsible for monitoring clinical trials and ensuring investigators are conducting the research within requirements of ...

ICON

Clinical Research Associate

Clinical Research Associate - Multi TA/Oncology - US ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients ...

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Principal Clinical Research Associate information

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$12

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How much do principal clinical research associate jobs pay per hour?

As of Sep 8, 2026, the average hourly pay for principal clinical research associate in the United States is $41.13, according to ZipRecruiter salary data. Most workers in this role earn between $28.85 and $52.64 per hour, depending on experience, location, and employer.

What is a principal clinical research associate?

A Principal Clinical Research Associate (Principal CRA) is a senior-level professional responsible for overseeing and monitoring clinical trials to ensure they are conducted according to regulatory requirements, protocols, and Good Clinical Practice (GCP) guidelines. They often serve as the primary point of contact between the clinical trial sponsor and the investigational sites, providing guidance, training, and support to site staff and less experienced CRAs. Principal CRAs may also contribute to protocol development, site selection, and data review, ensuring the integrity and quality of clinical data collected during a study. Their expertise and leadership play a critical role in the successful execution of complex clinical research projects.

What are the key skills and qualifications needed to thrive as a principal clinical research associate?

To thrive as a Principal Clinical Research Associate, you need deep knowledge of clinical trial protocols, regulatory requirements (such as GCP/ICH), and typically a bachelor's degree in a life science field with significant experience in clinical research. Familiarity with electronic data capture (EDC) systems, CTMS platforms, and relevant certifications like ACRP or SOCRA are commonly required. Exceptional organizational skills, attention to detail, and strong leadership and communication abilities help you effectively manage study sites and teams. These skills are crucial for ensuring clinical trials are conducted ethically, efficiently, and in compliance with all regulatory standards.

How does a principal clinical research associate typically collaborate with cross-functional teams during a clinical trial?

As a Principal Clinical Research Associate (PCRA), you will frequently act as a key liaison between clinical sites, sponsors, and internal departments such as data management, regulatory affairs, and project management. Collaboration often involves leading site monitoring activities, ensuring protocol compliance, and communicating updates or issues to relevant stakeholders. PCRAs may also mentor junior CRAs, contribute to study planning meetings, and help resolve complex site or regulatory challenges, making team coordination and communication crucial aspects of the role.

What is the difference between Principal Clinical Research Associate vs Clinical Research Associate?

AspectPrincipal Clinical Research AssociateClinical Research Associate
Required credentialsBachelor's degree, often advanced certifications, experience in clinical trialsBachelor's degree, relevant experience, often entry to mid-level
Work environmentLeads multiple sites, oversees study progress, mentors teamMonitors individual sites, ensures protocol compliance
Employer usagePharmaceutical companies, CROs, biotech firmsSame as Principal, often as entry/mid-level role

The Principal Clinical Research Associate typically has more experience, oversees multiple sites, and takes on leadership responsibilities, while the Clinical Research Associate focuses on monitoring individual sites and ensuring protocol adherence. Both roles are essential in clinical trials, but the Principal role involves higher-level oversight and strategic input.

What cities are hiring for Principal Clinical Research Associate jobs?

Cities with the most Principal Clinical Research Associate job openings:

Who are the top companies hiring for Principal Clinical Research Associate jobs?

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What states have the most Principal Clinical Research Associate jobs?

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What are popular job titles related to Principal Clinical Research Associate jobs?

For Principal Clinical Research Associate jobs, the most frequently searched job titles are:

Principal Clinical Research Associate jobs near you
Infographic showing various Principal Clinical Research Associate job openings in the United States as of August 2026, with employment types broken down into 3% As Needed, 74% Full Time, 15% Part Time, and 8% Contract. Highlights an 85% Physical, 1% Hybrid, and 14% Remote job distribution, with an average salary of $85,542 per year, or $41.1 per hour.

Clinical Research Associate I

Omaha, NE • On-site

University of Nebraska Medical Center
Colleges, Universities, and Professional Schools • 1 - 5K employees
Learn more about University of Nebraska Medical Centerexternal

$18.99 - $28.51/hr

Full-time

Re-posted 23 days ago

University Of Nebraska Medical Center rating

8.5

Company rating: 8.5 out of 10

Based on 15 frontline employees who took The Breakroom Quiz

55th of 1,066 rated hospitals

Job description

GENERAL REQUISITION INFORMATION
EEO Statement:
UNMC is an Equal Employment Opportunity Employer, including an equal opportunity employer of protected veterans and individuals with disabilities.
Location Omaha, NE Requisition Number: Staff_14495 Department Int Med DEM 50000586 Business Unit College of Medicine Reg-Temp Full-Time Regular Work Schedule As directed by supervisor Remote/Telecommuting No remote/telecommuting opportunity Position Summary
Provide clinical and administrative support for the division of DEM (Diabetes, Endocrinology and Metabolism) in the areas of clinical research and regulatory compliance. Support administrator with the processing of all IRB and regulatory paperwork. Duties will also include working with current and potential research subjects.
Position Details
Additional Information
Posting Category Research - Non Academic Working Title Clinical Research Associate I Job Title Clinical Research Associate L1 Salary Grade RA14H Appointment Type C2 - REG OFF/SERV HRLY Salary Range $18.990 - $28.510/hourly Job Requisition Begin Date 02/13/2026 Application Review Date 02/24/2026 Review Date Information:
Initial application review will begin on the date provided in the field above. Applications received prior to this review date will be considered. Applications received after the review date may be considered.
Required and Preferred Qualifications
Required Education: High School education or equivalent If any degree major/training is required, please specify the type. (NOTE: Concentration and minors are not equivalent to a major)
(Will consider three years related post high school education/experience)
Required Experience 3 years If any experience is required, please specify what kind of experience:
Experience related to healthcare, laboratory and/or clinical research
(Will consider three years related post high school education/experience)
Required License No If yes, what is the required licensure/certification? Required Computer Applications: Microsoft Excel, Microsoft Word, Microsoft PowerPoint, Microsoft Outlook Required Other Computer Applications: Required Additional Knowledge, Skills and Abilities:
Exceptional organization skills.
Ability to communicate effectively both verbally and in writing.
Ability to prioritize and work independently.
Preferred Education: Relevant coursework/specialized training If any degree/training is preferred, please specify the type:
Training related to healthcare, laboratory and/or clinical research.
Preferred Experience: Preferred License: No If yes, what is the preferred licensure/certification?: Preferred Computer Applications: SAP, Microsoft Outlook Preferred Other Computer Applications: Electronic Health Records Preferred Additional Knowledge, Skills and Abilities: Email to a Friend https://unmc.peopleadmin.com/postings/96314

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