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Postdoctoral Small Molecules Jobs (NOW HIRING)

University of Miami

Postdoctoral Associate

Miami, FL · On-site

The Department of Biochemistry & Molecular Biology is currently seeking a full time Postdoctoral ... of small molecules and biologics. The role will lead formulation and materials selection, 3D ...

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How much do postdoctoral small molecules jobs pay per year?

As of Jun 7, 2026, the average yearly pay for postdoctoral small molecules in the United States is $59,022.00, according to ZipRecruiter salary data. Most workers in this role earn between $49,000.00 and $66,500.00 per year, depending on experience, location, and employer.

What are postdoctoral small molecules researchers?

Postdoctoral small molecules researchers are scientists who have completed their PhD and are engaged in advanced research related to the discovery, synthesis, and analysis of small molecule compounds. These researchers often work in academic, pharmaceutical, or biotechnology settings, contributing to projects such as drug development, chemical biology, or medicinal chemistry. Their work involves designing experiments, analyzing data, and publishing findings that can lead to new therapeutics or scientific insights. Postdoctoral positions are typically temporary and focused on gaining specialized skills and experience before moving into more permanent roles.

What are some common challenges faced by postdoctoral researchers working with small molecules, and how can they overcome them?

Postdoctoral researchers focusing on small molecules often encounter challenges such as troubleshooting complex synthetic pathways, optimizing reaction yields, and ensuring compound purity. They may also need to interpret ambiguous analytical data and manage tight project timelines. Collaborating closely with interdisciplinary teams, including chemists, biologists, and analytical specialists, is crucial for overcoming these hurdles. Staying organized, seeking mentorship, and leveraging available instrumentation and expertise within the lab can significantly improve problem-solving and project outcomes.

What are the key skills and qualifications needed to thrive as a Postdoctoral Researcher specializing in Small Molecules, and why are they important?

To excel as a Postdoctoral Researcher in Small Molecules, you typically need a PhD in chemistry, biochemistry, or a related field with a strong background in organic synthesis and molecular characterization. Familiarity with analytical tools such as NMR, HPLC, mass spectrometry, and computational chemistry software, along with experience in laboratory best practices, is crucial. Strong problem-solving abilities, attention to detail, and effective collaboration and communication skills set outstanding candidates apart. These competencies ensure rigorous scientific discovery, reproducible results, and productive teamwork in research-driven environments.
Infographic showing various Postdoctoral Small Molecules job openings in the United States as of May 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $59,022 per year, or $28.4 per hour.
Postdoctoral Fellow - Yeh Lab

Postdoctoral Fellow - Yeh Lab

Cold Spring Harbor Laboratory

Cold Spring Harbor, NY • On-site

$72K/yr

Full-time

Medical, Retirement, PTO

Posted 25 days ago

Job description

Salary: $72,800.00 Annually
Location : 1 Bungtown Road, Cold Spring Harbor- Main Campus
Job Type: Full Time
Job Number: 02869-R
Process Level: Scientific Laboratory
Department: Yeh Laboratory
Opening Date: 02/05/2024
Position Description
A Postdoc Fellow position is available at The Yeh Laboratory at CSHL Cancer Center (). We are recruiting new members passionate about drug discovery and chemical biology. Our lab is working to understand the molecular mechanisms leading to efficient elicitation of tumor vulnerability for potent cancer targeting. We develop Targeted Protein Degradation (TPD) therapeutic strategies to abrogate or rewire cancer cell signaling. We have recently established a new discovery platform to expand the landscape of TPD E3 ligases and targeting modalities beyond conventional small molecules (Genes & Development (2022) 36:1031-1042.; Genes & Development (2023) 37: 1-17). For this open position, the project direction will be focused on continuing developing and validating novel TPD molecules to target undruggable proteins. The Yeh Lab is a highly-collaborative environment with state-of-the-art facilities and expertise in biotherapeutics engineering and chemical biology. We feature multidiscipline approaches to tackle scientific questions. The Yeh Lab also engages in several close collaborations with other research groups at the Cancer Center. This postdoc fellow will be part of a new Chemical Biology initiative at CSHL and will enjoy the highly intellectual and collaborative interactions at CSHL, including accessing CSHL conferences on cutting edge scientific discoveries.
PhD candidates expecting to complete by 2024 are encouraged to apply. Candidates with expertise in organic synthesis, peptide/ natural product/macrocycle chemistry, or chemical biology related to medicinal chemistry are highly desired.
Position Requirements
EDUCATION: Successful applicants should possess a Ph.D. degree or equivalent in a life science or chemistry discipline at the time of appointment.
Experience/Skill: Expertise in organic synthesis, macrocycle and peptide/protein chemistry or chemical biology are strongly desired. PhD candidates expecting to complete their degree in 2024 are encouraged to apply. This postdoc fellow will also be part of a new Chemistry for Biology initiative at CSHL.
For immediate consideration, please include your CV & cover letter in the online application found here:Position ID: 02869-R. In addition, please also send a copy of your CV & cover letter to jyeh@cshl.edu.
Supplemental Information
EnvironmentCold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program. We believe that science is for everyone and our researchers have a wide variety of backgrounds.
Compensation and Benefits
Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, paid time off, and a range of recognition and wellness programs. Visit our CSHL Benefits , Postdoctoral Landing & sites to learn more. The salary for this role is $73,400.00 per annum. The salary range or hourly rate listed is a good faith determination of potential base compensation that may be offered to a successful applicant for this position at the time of this job advertisement and may be modified in the future. When determining a base salary and/or rate, several factors may be considered as applicable (e.g., years of relevant experience, education, credentials, and internal equity).
CSHL is an EO Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, or protected veteran status. VEVERAA Federal Contractor
CSHL Postdoctoral Fellows are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, padi time off, relocation reimbursement, a Wellness Center and access to an affordable and licensed on-site childcare center. Visit our & sites to learn more.

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